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Cat. No.: HY-129289

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NSC 13987

NSC 13987 is a Nef site I inhibitor. NSC 13987 binds to Nef site I and disrupts the Nef-calnexin interaction. NSC 13987 restores cholesterol efflux inhibited by Nef. NSC 13987 is applicable to the research of HIV-associated atherosclerosis.

For research use only. We do not sell to patients.

CAS No.: 81-94-7
Formula: C₃₁H₁₇NO₃
Molecular Weight:451.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NSC 13987 Chemical Structure

CAS No.: 81-94-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

HIV-1 Nef

All HIV Isoforms :

Chemical Information

CAS No. 81-94-7
Molecular Weight 451.47
Formula C₃₁H₁₇NO₃
SMILES

O=C1C2=C(C(C3=CC=CC(NC(C=CC4=C56)=C6C=CC=C5C(C7=CC=CC=C74)=O)=C13)=O)C=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Signal Pathway Related

Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Adzhubei AA, et al. Modelling interaction between HIV-1 Nef and calnexin. AIDS. 2018;32(15):2103-2111. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols
Purity & Documentation
References

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NSC 13987

All HIV Isoforms

Biological Activity

Description

IC50 & Target

Chemical Information

Protocols

Purity & Documentation

References

Calculators

Help & FAQs

NSC 13987 Related Classifications

HY-129289 Related Classifications

Bioz

Keywords

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