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  4. Mezolidon

Mezolidon (KM-1146) is an anti-ulcer agent with weak gastric acid secretion inhibitory activity. Mezolidon prevents the formation of gastric mucosal ulcers in stressed rats, increases and maintains their gastric mucosal blood flow, and inhibits the decrease in their transmucosal potential difference. Mezolidon can be used in the research of gastric ulcers.

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Mezolidon

Mezolidon Chemical Structure

CAS No. : 82697-73-2

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Description

Mezolidon (KM-1146) is an anti-ulcer agent with weak gastric acid secretion inhibitory activity. Mezolidon prevents the formation of gastric mucosal ulcers in stressed rats, increases and maintains their gastric mucosal blood flow, and inhibits the decrease in their transmucosal potential difference. Mezolidon can be used in the research of gastric ulcers[1].

In Vivo

Mezolidon (300 mg/kg; i.p.; single dose; 30 minutes before water-immersion stress initiation) significantly prevents gastric ulcer development in water-immersion restraint stress-exposed rats, with efficacy linked to increased and maintained gastric mucosal blood flow and suppressed reductions in gastric mucosal potential difference, while having no effect on gastroduodenal surface pH or blood viscosity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, 160-180 g, gastric ulcer induced by 3-hour water-immersion restraint stress in urethane-anesthetized rats)[1]
Dosage: 300 mg/kg
Administration: i.p.; single dose; 30 minutes before water-immersion stress initiation
Result: Reduced the total length of gastric ulcers to 3.67 mm relative to the control group.
Elevated gastric mucosal blood flow to 119.8% of baseline at 20 min post-stress and 119.2% of baseline at 30 min post-stress, and sustained mucosal blood flow at 66.6% of baseline at 180 min post-stress, both superior to the control group.
Inhibited the decline of gastric mucosal potential difference (PD) at 120 and 180 min post-stress, retaining PD at higher levels than the control group.
Exerted no obvious influence on gastroduodenal mucosal surface pH or water-immersion stress-triggered elevation of blood viscosity.
Molecular Weight

253.32

Formula

C12H15NO3S
CAS No.
SMILES

O=C1NC(C2=CC=C(OC)C(OC)=C2)SC1C
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mezolidon82697-73-2KM-1146KM1146KM 1146Biochemical Assay Reagentsstressed ratswater-immersion restraint stress-exposed ratshistamineblood viscositygastric mucosal ulcertransmucosal potential differencegastroduodenal mucosal surface pHgastric ulcergastric mucosal blood flowcarbacholInhibitorinhibitorinhibit

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