Mezolidon
Mezolidon (KM-1146) is an anti-ulcer agent with weak gastric acid secretion inhibitory activity. Mezolidon prevents the formation of gastric mucosal ulcers in stressed rats, increases and maintains their gastric mucosal blood flow, and inhibits the decrease in their transmucosal potential difference. Mezolidon can be used in the research of gastric ulcers.
For research use only. We do not sell to patients.
- CAS No.: 82697-73-2
- Formula: C12H15NO3S
- Molecular Weight:253.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 160-180 g, gastric ulcer induced by 3-hour water-immersion restraint stress in urethane-anesthetized rats)[1]
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Dosage:300 mg/kg
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Administration:i.p.; single dose; 30 minutes before water-immersion stress initiation
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Result:Reduced the total length of gastric ulcers to 3.67 mm relative to the control group.
Elevated gastric mucosal blood flow to 119.8% of baseline at 20 min post-stress and 119.2% of baseline at 30 min post-stress, and sustained mucosal blood flow at 66.6% of baseline at 180 min post-stress, both superior to the control group.
Inhibited the decline of gastric mucosal potential difference (PD) at 120 and 180 min post-stress, retaining PD at higher levels than the control group.
Exerted no obvious influence on gastroduodenal mucosal surface pH or water-immersion stress-triggered elevation of blood viscosity.
Chemical Information
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CAS No. 82697-73-2
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Molecular Weight 253.32
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Formula C12H15NO3S
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SMILES
O=C1NC(C2=CC=C(OC)C(OC)=C2)SC1C
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Synonyms
KM-1146
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mezolidon Related Classifications
HY-129424 Related Classifications
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- Mezolidon
- 82697-73-2
- KM-1146
- KM1146
- KM 1146
- Biochemical Assay Reagents
- stressed rats
- water-immersion restraint stress-exposed rats
- histamine
- blood viscosity
- gastric mucosal ulcer
- transmucosal potential difference
- gastroduodenal mucosal surface pH
- gastric ulcer
- gastric mucosal blood flow
- carbachol
- Inhibitor
- inhibitor
- inhibit