2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

PDF 93.1 MB

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-163998
    TLR4-IN-1 2617578-93-3 98%
    TLR4-IN-1 (compound 3k) inhibits the cell viability of RAW264.7 with an IC50 of 1.02 μM. TLR4-IN-1 inhibits the release of cytokine TNF-α, IL-1β and IL-6, and exhibits anti-inflammatory efficacy in rats rheumatoid arthritis models.
    TLR4-IN-1
  • HY-164010
    SUN-1334H free base 607737-00-8 98%
    SUN-1334H free base is an orally active inhibitor for histamine H1 receptor, with an IC50 of 20.3 nM and Ki of 9.7 nM. SUN-1334H free base inhibits histamine-induced contractions of isolated guinea-pig ileum with an IC50 of 0.198 μM. SUN-1334H free base inhibits histamine-induced bronchoconstriction in guinea pigs, histamine-induced skin wheals in beagle dogs, and ovalbumin-induced rhinitis in guinea pigs.
    SUN-1334H free base
  • HY-164037
    Riselcaftor 2799652-36-9 98%
    Riselcaftor (Example 33) is a CFTR modulator, with an EC50 of 20.1 nM in human bronchial epithelial cells. Riselcaftor can be used for research of cystic fibrosis.
    Riselcaftor
  • HY-164133
    SM00465 2983179-22-0
    SM00465 (Compound 207) is a Cbl-b inhibitor-linker conjugate composed of INT4 (HY-179262) and Linker (HY-179263). SM00465 can be used for ADC synthesis. SM00465 is applicable to the research of immune-related diseases.
    SM00465
  • HY-164177
    STAT6 modulator-3 2978689-80-2 98%
    STAT6 modulator-3 (compound 37) is a STAT6 modulator with an IC50 value less than 300 nM. STAT6 modulator-3 can be used in the research of cancer and inflammatory.
    STAT6 modulator-3
  • HY-164216
    STAT6-IN-13 2952723-82-7
    STAT6-IN-13 (Compound 22) is a STAT6 inhibitor with IC50 values of ≤300 nM. STAT6-IN-13 has weak inhibitory for STAT3. STAT6-IN-13 can be used for the researches of cancer, inflammation and immunology.
    STAT6-IN-13
  • HY-164298
    MRGPRX2 modulator-3 2765728-26-3
    MRGPRX2 modulator-3 (Compound 4-400) is a quinoline derivative and a MRGPRX2 modulator. MRGPRX2 modulator-3 can be used in the research of MRGPRX2-related diseases, such as allergies, pruritus, pain, inflammation and autoimmune diseases, etc.
    MRGPRX2 modulator-3
  • HY-164386
    Defoslimod 171092-39-0 98%
    Defoslimod (OM 174) is an agonist for TLR4 receptor and acts as an immunomodulator. Defoslimod activates macrophages and dendritic cells, induces cytokines secretion, and exhibits antitumor efficacy in rats.
    Defoslimod
  • HY-164650
    Pirodomast 108310-20-9 98%
    Pirodomast (Sch 37224) is a leukotriene formation inhibitor. Pirodomast inhibits LTD4 andthromboxane B2 release by anaphylactic guinea pig lung with the IC50 values of 3.9 and 1.9 μM, respectively. Pirodomast can be used for study of asthma.
    Pirodomast
  • HY-164799
    FXR agonist 12 1831862-88-4 98%
    FXR agonist 12 (Compound C7) is the orally active agonist for FXR. FXR agonist 12 down-regulates bile acid synthesis-related genes, and up-regulates bile acid transport-related genes in HepG2 cells. FXR agonist 12 improves ANIT-induced cholestasis, ameliorates the liver damage and fibrosis in mouse NASH models.
    FXR agonist 12
  • HY-164870
    FFAR1/FFAR4 agonist-1 2839486-16-5 98%
    FFAR1/FFAR4 agonist-1 (compound 83) is a FFAR1/FFAR4 agonist with the EC50 of 1 nM A and 4nM for FFAR1 and FFAR4, respectively. FFAR1/FFAR4 agonist-1 can be used for study of glycemic control.
    FFAR1/FFAR4 agonist-1
  • HY-164910
    AHL-Pu-2 1838570-66-3 98%
    AHL-Pu-2 is the clickable electrophilic purine. AHL-Pu-2 can be used to directly quantify protein-RNA interactions on proteins through photoaffinity competition with 4-thiouridine (4SU)-labeled RNA in cells.
    AHL-Pu-2
  • HY-165061
    5(Z),11(Z),14(Z)-Eicosatrienoic acid 7019-85-4 98%
    5(Z),11(Z),14(Z)-Eicosatrienoic acid (Sciadonic acid), a polyunsaturated fatty acid sourced from maritime pine seed oil, gymnospermae leaves and seeds, and freshwater gastropods, has been shown to reduce high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1 when included in their diet. In vitro studies indicate that it diminishes cholesterol efflux, and when applied topically in its methyl ester form, it alleviates inflammatory processes, likely by displacing arachidonic acid from phospholipid pools and lowering concentrations of downstream inflammatory mediators such as prostaglandin E2 and leukotrienes.
    5(Z),11(Z),14(Z)-Eicosatrienoic acid
  • HY-165315
    Lysyl-serine 6665-19-6 98%
    Lysyl-serine (TCMP-80) is a T cell modulatory peptide with immunomodulatory properties.
    Lysyl-serine
  • HY-165327
    AGN-190383 120755-15-9
    AGN-190383 is a bee venom phospholipase A2 inhibitor. AGN 190383 inhibits both hormone-operated and depolarization-dependent calcium mobilization as well as fMLP stimulated increases in free cytosolic calcium. AGN-190383 has anti-inflammatory activity.
    AGN-190383
  • HY-165370
    BMS-791826 1008116-73-1 98%
    BMS-791826 is a selective glucocorticoid receptor modulator. BMS-791826 effectively binds to glucocorticoid receptors and effectively inhibits AP-1 and NF-κB-dependent reporter. BMS-791826 can be used in the research of inflammatory diseases.
    BMS-791826
  • HY-165374
    AY-30068 106464-24-8
    AY-30068 is an orally effective analgesic. AY-30068 exists in the enterohepatic circulation and has a long-lasting analgesic effect.
    AY-30068
  • HY-165385
    AZ-DF 265 83901-40-0
    AZ-DF 265 is a hypoglycemic agent that stimulates insulin release. AZ-DF-265 inhibits ATP-sensitive potassium channels, activates voltage-dependent calcium channels, allows calcium ion influx, and ultimately promotes insulin secretion. AZ-DF 265 can be used in diabetes-related research.
    AZ-DF 265
  • HY-165394
    Melafolone 129724-42-1 98%
    Melafolone is a potent dual COX-2/EGFR inhibitor with IC50s of 13.2 μM (COX-2) and 17.4 μM (EGFR). Melafolone enhances the effect of anti-PD-1 through vascular normalization and PD-L1 downregulation via the PI3K/Akt pathway in Lewis lung carcinoma (LLC) and CMT167 models. Melafolone can be used for lung cancer research.
    Melafolone
  • HY-165395
    AY 25674 65425-48-1 98%
    AY 25674 is an orally active antiallergic agent and a PDE inhibitor. AY 25674 inhibits the release of allergic histamine from mast cells. AY 25674 suppresses passive anaphylaxis induced by reaginic (IgE) antibodies. AY 25674 does not inhibit the increased vascular permeability caused by non-reaginic antibodies, serotonin or histamine. AY 25674 reaches its peak activity shortly after administration; rapid tolerance occurs at high doses. AY 25674 can be used in research related to passive anaphylaxis.
    AY 25674
Cat. No. Product Name / Synonyms Application Reactivity