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Cat. No.: HY-165385

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AZ-DF 265

AZ-DF 265 is a hypoglycemic agent that stimulates insulin release. AZ-DF-265 inhibits ATP-sensitive potassium channels, activates voltage-dependent calcium channels, allows calcium ion influx, and ultimately promotes insulin secretion. AZ-DF 265 can be used in diabetes-related research.

For research use only. We do not sell to patients.

CAS No.: 83901-40-0
Formula: C₂₇H₂₈N₂O₃
Molecular Weight:428.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AZ-DF 265 Chemical Structure

CAS No.: 83901-40-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

All Calcium Channel Isoforms :

In Vitro

AZ-DF 265 reduces potassium ion permeability of pancreatic β-cell membranes, thereby inducing membrane depolarization, activating voltage-dependent calcium channels, allowing calcium ion influx, and ultimately promoting insulin secretion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AZ-DF 265 exerts potent hypoglycemic effects in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 83901-40-0
Molecular Weight 428.53
Formula C₂₇H₂₈N₂O₃
SMILES

O=C(O)C1=CC=C(C=C1)CC(=O)NC(C=2C=CC=CC2)C=3C=CC=CC3N4CCCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Garrino MG, et al. Highly potent and stereoselective effects of the benzoic acid derivative AZ-DF 265 on pancreatic beta-cells. Br J Pharmacol. 1988;93(1):61-68. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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AZ-DF 265

All Calcium Channel Isoforms