Melafolone
Melafolone is a potent dual COX-2/EGFR inhibitor with IC50s of 13.2 μM (COX-2) and 17.4 μM (EGFR). Melafolone enhances the effect of anti-PD-1 through vascular normalization and PD-L1 downregulation via the PI3K/Akt pathway in Lewis lung carcinoma (LLC) and CMT167 models. Melafolone can be used for lung cancer research.
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- CAS. Nr.: 129724-42-1
- Formel: C22H24O7
- Molecular Weight:400.42
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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COX-2 13.2 μM (IC50) |
EGFR 17.4 μM (IC50) |
Chemical Information
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CAS. Nr. 129724-42-1
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Molecular Weight 400.42
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Formel C22H24O7
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SMILES
O=C(C1=C(C(OC(C(C)CC)=O)=C(C(OC)=C1O)O)OC)/C=C/C2=CC=CC=C2
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Melafolone Related Classifications
HY-165394 Related Classifications
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