129724-42-1
129724-42-1
Chemical Structure
Melafolone
- CAS No.: 129724-42-1
- Formula:C22H24O7
- Molecular Weight:400.42
InChIKey: BICSVVFMOSJUCU-VAWYXSNFSA-N
SMILES: O=C(C1=C(C(OC(C(C)CC)=O)=C(C(OC)=C1O)O)OC)/C=C/C2=CC=CC=C2
Biological Activity: Melafolone is a potent dual COX-2/EGFR inhibitor with IC50s of 13.2 μM (COX-2) and 17.4 μM (EGFR). Melafolone enhances the effect of anti-PD-1 through vascular normalization and PD-L1 downregulation via the PI3K/Akt pathway in Lewis lung carcinoma (LLC) and CMT167 models. Melafolone can be used for lung cancer research[1].
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Melafolone | Melafolone is a potent dual COX-2/EGFR inhibitor with IC50s of 13.2 μM (COX-2) and 17.4 μM (EGFR). Melafolone enhances the effect of anti-PD-1 through vascular normalization and PD-L1 downregulation via the PI3K/Akt pathway in Lewis lung carcinoma (LLC) and CMT167 models. Melafolone can be used for lung cancer research. | |||||||||||||||||||||
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References
Keywords
