2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

PDF 93.1 MB

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W207224
    F1386-0303 287177-12-2 98%
    F1386-0303 is a highly selective MAP4K4 inhibitor with an IC50 of 34 nM against human targets. F1386-0303 exerts cardiomyocyte protective and function-preserving effects through mechanisms such as alleviating oxidative stress, inhibiting caspases, and maintaining mitochondrial membrane potential, while it does not interfere with the activity of Doxorubicin (HY-15142A) in cancer cells. F1386-0303 is rapidly cleared and has no bioavailability in mice, but it is well-suited as a tool compound for target validation. F1386-0303 can be applied to studies related to cardiac ischemia-reperfusion injury, Doxorubicin-induced cardiotoxicity, myocardial infarction and other related conditions.
    F1386-0303
  • HY-W207699
    MAO-B-IN-46 27052-20-6 98%
    MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC50: 26.8 nM), with weak activity against hMAO-A (IC50: 7.2054 μM). MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC50: 19.46 μM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC50 values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance.
    MAO-B-IN-46
  • HY-W230975
    (E/Z)-Piperine 7780-20-3 98.91%
    (E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer’s disease and Parkinson’s disease.
    (E/Z)-Piperine
  • HY-W265961
    Squoxin 1096-84-0 98%
    Squoxin (ST1859) is an antiamyloid agent that specifically binds to Aβ1-42 and prevents the aggregation and fibril formation of Aβ. Squoxin crosses the blood-brain barrier (BBB) and has anthelmintic activity and anti-inflammatory properties.
    Squoxin
  • HY-W267161
    (3R,4R)-3-Methyl-4-piperidinol 373604-43-4 98%
    (3R,4R)-3-Methyl-4-piperidinol is a PROTAC linker. (3R,4R)-3-Methyl-4-piperidinol can be used for the synthesis of PROTAC BCL6 Degrader-3 (HY-186067).
    (3R,4R)-3-Methyl-4-piperidinol
  • HY-W271506
    TMPO 10135-38-3 98%
    TMPO (3,3,5,5-Tetramethyl-1-pyrroline 1-oxide) is a spin trap targeting free radicals. TMPO is capable of scavenging superoxide, hydroxyl radicals and inhibits thymocyte apoptosis with EC50 values of 19.1 mM (MPS-induced) to 30.7 mM (Etoposide-induced) for inhibiting DNA fragmentation. TMPO reacts with intracellular free radicals to form stable nitroxide radical products, reducing oxidative stress (e.g., decreasing peroxide levels, maintaining glutathione content) and blocking oxidative events in the apoptotic pathway. TMPO is promising for research of apoptosis in immune cells like thymocytes.
    TMPO
  • HY-W272207
    AChE/BChE-IN-31 6338-81-4 98%
    AChE/BChE-IN-31 (Compound 3c) is a cholinesterase inhibitor. AChE/BChE-IN-31 exhibits certain inhibitory activity against hAChE and eqBChE. AChE/BChE-IN-31 also possesses antioxidant properties with an IC50 value of 105.04 μM against DPPH. AChE/BChE-IN-31 can be used in the research of diseases such as Alzheimer’s disease.
    AChE/BChE-IN-31
  • HY-W277900
    2-Methoxy-2,4-diphenylfuran-3-one 50632-57-0 98%
    2-Methoxy-2,4-diphenylfuran-3-one is a fluorescent compound which can be used to label gelatin as a substrate for detection of the gelatin degrading MMP-2 and MMP-9 by zymography.
    2-Methoxy-2,4-diphenylfuran-3-one
  • HY-W281862
    Sequifenadine 57734-69-7 98%
    Sequifenadine is a H1-antihistamine. Sequifenadine has the potential for the research of inflammatory eye disease with allergic symptoms.
    Sequifenadine
  • HY-W286423
    L-Pyroglutamic acid 7-amido-4-methylcoumarin 66642-36-2 98%
    L-Pyroglutamic acid 7-amido-4-methylcoumarin is a fluorogenic substrate for pyroglutamate aminopeptidase 1 (PGP-1).
    L-Pyroglutamic acid 7-amido-4-methylcoumarin
  • HY-W309310
    Etofesalamide 64700-55-6 98%
    Etofesalamide is a nonsteroidal antiinflammatory agent. Etofesalamide has major phase II metabolites of glucoside and riboside conjugations (such as etofesalamide-2-glucuronide) in filamentous fungi. Etofesalamide can be used for allergic and autoimmune skin diseases like toacne, psoriasis and sensitization dermatitis research.
    Etofesalamide
  • HY-W333234
    Clofenamic acid 13278-36-9 98%
    Clofenamic acid (2-(3-Chloroanilino)benzoic acid) is a nonsteroidal anti-inflammatory drug. Clofenamic acid can be used for the research of rheumatoid arthritis.
    Clofenamic acid
  • HY-W335927
    MAO-B-IN-19 152897-41-1 98%
    MAO-B-IN-19 is a selective MAO-B inhibitor with an IC50 of 0.67 μM. MAO-B-IN-19 shows neuroprotective and anti-inflammatory properties.
    MAO-B-IN-19
  • HY-W338346
    Salicylate choline 2016-36-6 98%
    Salicylate choline is an orally active derivative of Aspirin (acetylsalicylic acid) (HY-14654). Salicylate choline significantly reduces IL-1β, IL-6, TNF-α and IL-10 levels in cells. Salicylate choline enhances the anti-tumor activity of the CRM1 inhibitor Selinexor (KPT-330) (HY-17536) through inducing S-phase cell cycle arrest and impairing DNA damage repair. Salicylate choline combined with Selinexor demonstrates excellent anti-tumor efficacy in mice xenograft model harboring JeKo-1 cells. Salicylate choline can be used for the study of rheumatic diseases, inflammation and cancer.
    Salicylate choline
  • HY-W339645
    Naproxen ethyl ester 31220-35-6 98%
    Naproxen ethyl ester ((S)-Naproxen ethyl ester) is a nonsteroidal anti-inflammatory drug with activity in relieving pain, fever, swelling and stiffness. Naproxen ethyl ester exerts its effects by inhibiting non-selective cyclooxygenase (COX). The R-(-)-isomer of Naproxen ethyl ester shows stronger immunogenicity, and the Michaelis-Menten parameter of its catalytic reaction is K(M)=6.67 mM, and the catalytic efficiency is 5.8 x 10^4 times higher than that of the non-catalytic reaction.
    Naproxen ethyl ester
  • HY-W342853
    HPSE-IN-1 58954-23-7 98%
    HPSE-IN-1 (Compound 31) is a heparanase inhibitor with an IC50 of 970 µM. HPSE-IN-1 can be used in the research of inflammatory diseases and cancer.
    HPSE-IN-1
  • HY-W344531
    Indomethacin glucuronide 75523-11-4 98%
    Indomethacin glucuronide is a glucuronide metabolite of Indomethacin (HY-14397).
    Indomethacin glucuronide
  • HY-W345148
    2-Naphthylamine-6,8-disulfonic acid potassium 842-15-9 98%
    2-Naphthylamine-6,8-disulfonic acid potassium is chemical that can be used for preparing dyestuff, medicine, agricultural chemicals etc.
    2-Naphthylamine-6,8-disulfonic acid potassium
  • HY-W357142
    3-Acetylumbelliferyl β-D-Glucopyranoside 20943-16-2 98%
    3-Acetylumbelliferyl β-D-Glucopyranoside is a fluorogenic substrate for β-glucosidase and can be used as a positive control substrates for β-D-glucosidase.
    3-Acetylumbelliferyl β-D-Glucopyranoside
  • HY-W371164
    C1s-IN-1 1016866-61-7 98%
    C1s-IN-1 (compound A1) is a selective and competitive inhibitor of C1s. C1s-IN-1 binds directly to C1s with a Kd of 9.8 μM.
    C1s-IN-1
Cat. No. Product Name / Synonyms Application Reactivity