Inflammation/Immunology

PCF-39 is a Hypoxanthine (HY-N0091) derivative and immunomodulator agent. PCF-39 induces an increased spleen cellularity.

Bisisorhapontigenin A is a dimer of isorhapontigenin. Bisisorhapontigenin A exhibits antagonistic activity against LTD4 and can be used for research on anti-inflammatory effects.

Anti-Amyloid Beta Antibody (CNTO 2125) is a humanized antibody expressed in CHO cells, targeting Amyloid Beta/Aβ. Anti-Amyloid Beta Antibody (CNTO 2125) features a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-Amyloid Beta Antibody (CNTO 2125) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Mouse IgG Fab fragment is a fragment of antigen (Fab) of mouse immunoglobulin G (IgG) molecules that can be used as an immunolabel in various immunoassays, including ELISA.

Olpasiran sodium scrambled negative control is the sequence scrambled negative control of Olpasiran sodium.

pan-KRAS-IN-20 is a pan-KRAS inhibitor. pan-KRAS-IN-20 can be used for the researches of cancer, tumors, inflammatory diseases, autoimmune diseases or immune-mediated diseases.

RTX-002 is a human monoclonal antibody (mAb) targeting PDCD1/PD-1/CD279. RTX-002 can be used to study autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis.

Sulfacetamide-¹³C₆ (Sulphacetamide¹³C₆) is the ¹³C₆ labeled Sulfacetamide (HY-N7123). Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide has antifungal and antibacterial activities.

ALK5-IN-84 (Compound 23) is an ALK5 inhibitor with a pK_i value of 9.35 against hALK5. When administered via inhalation, ALK5-IN-84 exhibits significant ALK5 inhibitory activity. ALK5-IN-84 is promising for the development of inhaled ALK5 inhibitors.

Chloroquine-d₅ (diphosphate) is the deuterium labeled Chloroquine (phosphate). Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM).

Anti-LILRB1 Antibody is a monoclonal antibody targeting LILRB1/CD85j/ILT2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LILRB1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells.

CPN-351 (compound 9a), a pentapeptide, is a selective antagonist of human NMUR1 with a pA₂ of 7.35. The antagonistic effect of CPN-351 on human NMUR1 is 10 times higher than that on NMUR2. CPN-351 can be used in the study of inflammation.

Highly purified Type II collagen, from mouse sternal cartilage (Mouse Type II collagen, immunization grade) is an immune grade collagen derived from mouse sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.

Thymocartin (TP 4) acetate is the 32-35 fragment of thymic factor (thymopoietin). Thymocartin acetate inhibits apoptosis of peripheral blood lymphocytes in HIV infected individuals. Thymocartin acetate is potential for immunodeficiency diseases research.

Flurandrenolide (Fludroxycortide; Flurandrenolone) (Standard) is the analytical standard of Flurandrenolide. This product is intended for research and analytical applications.

4″-C18 EGCG is a potent inhibitor of α-amylase and α-glucosidase with IC₅₀ values of 3.74 and 0.81 μM, respectively. 4″-C18 EGCG inhibits carbohydrate hydrolases, reduces oxidative stress and inflammation, and exhibits antidiabetic activity. 4″-C18 EGCG also downregulates proinflammatory cytokines and is cytotoxic to primary human peripheral blood mononuclear cells (PBMCs), non-cancer cell lines 3T3-L1, and HEK 293 at 50 μM.

Idesin is a compound found in the fruits of Idesia polycarpa. Idesin inhibits LPS (HY-D1056)-induced nitric oxide production with mild cytotoxicity.

Chitinase is a chitin-targeting enzyme with chitin hydrolysis activity. Chitinase inhibits chitin-induced innate type 2 inflammation in the lung. Chitinase augments chitin-free, allergen-induced Th2 inflammation. Chitinase mediates effector functions of IL-13.

Cathepsin K inhibitor 2 is a potent inhibitor of cathepsin K. Cathepsin K, Cat K is a cysteine protease expressed under the control of CTSK gene and closely related to osteoporosis, whose main function is to hydrolyze collagen. Cathepsin K inhibitor 2 has the potential for the research of osteoarthfitis (extracted from patent WO2021147882A1, compound 78).