2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

PDF 93.1 MB

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-101772R
    Ziritaxestat (Standard) 1628260-79-6 98%
    Ziritaxestat (Standard) is the analytical standard of Ziritaxestat. This product is intended for research and analytical applications. Ziritaxestat (GLPG1690) is a first-in-class autotaxin (ATX) inhibitor, with an IC50 of 131 nM and a Ki of 15 nM.
    Ziritaxestat (Standard)
  • HY-101784R
    NE 52-QQ57 (Standard) 1401728-56-0 98%
    NE 52-QQ57 (Standard) is the analytical standard of NE 52-QQ57 (HY-101784). This product is intended for research and analytical applications. NE 52-QQ57 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 has anti-inflammatory activity.
    NE 52-QQ57 (Standard)
  • HY-101786R
    KZR-504 (Standard) 1629052-78-3 98%
    KZR-504 (Standard) is the analytical standard of KZR-504 (HY-101786). This product is intended for research and analytical applications. KZR-504 is a highly selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.274 μM for LMP2 and LMP7, respectively. KZR-504 is of interest for the treatment of autoimmune disease.
    KZR-504 (Standard)
  • HY-101793R
    BMS-935177 (Standard) 1231889-53-4 98%
    BMS-935177 (Standard) is the analytical standard of BMS-935177 (HY-101793). This product is intended for research and analytical applications. BMS-935177 is a potent and selective reversible inhibitor of Bruton’s tyrosine kinase (Btk) with an IC50 of 3 nM.
    BMS-935177 (Standard)
  • HY-101805R
    SK1-IN-1 (Standard) 1218816-71-7 98%
    SK1-IN-1 (Standard) is the analytical standard of SK1-IN-1 (HY-101805). This product is intended for research and analytical applications. SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM.
    SK1-IN-1 (Standard)
  • HY-101810R
    Tazanolast (Standard) 82989-25-1 98%
    Tazanolast (Standard) (TO 188 (Standard)) is the analytical standard of Tazanolast (HY-101810). This product is intended for research and analytical applications. Tazanolast is a selective mast-cell-stabilizing agent, on ozone-induced airway hyperresponsiveness in guinea pigs.
    Tazanolast (Standard)
  • HY-101813R
    Laflunimus (Standard) 147076-36-6 98%
    Laflunimus (Standard) is the analytical standard of Laflunimus. This product is intended for research and analytical applications. Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726. Laflunimus is an orally active inhibitor of dihydroorotate dehydrogenase (DHODH). Laflunimus suppresses immunoglobulin (Ig) secretion, with IC50 values of 2.5 and 2 μM for IgM and IgG, respectively. Laflunimus also is a prostaglandin endoperoxide H synthase (PGHS) -1 and -2 inhibitor.
    Laflunimus (Standard)
  • HY-101830R
    Wy 49051 (Standard) 113418-56-7 98%
    Wy 49051 (Standard) is the analytical standard of Wy 49051 (HY-101830). This product is intended for research and analytical applications. Wy 49051 is a potent, orally active H1 receptor antagonist, with IC50 of 44 nM.
    Wy 49051 (Standard)
  • HY-101833R
    YM-264 (Standard) 131888-54-5 98%
    YM-264 (Standard) is the analytical standard of YM-264 (HY-101833). This product is intended for research and analytical applications. YM-264 is a selective, potent and orally active platelet-activating factor (PAF) antagonist with a pKi value of 8.85 for rabbit platelet membranes.
    YM-264 (Standard)
  • HY-101840R
    EIPA (Standard) 1154-25-2 98%
    EIPA (Standard) is the analytical standard of EIPA. This product is intended for research and analytical applications. EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.
    EIPA (Standard)
  • HY-101846R
    AX-15836 (Standard) 2035509-96-5 98%
    AX-15836 (Standard) is the analytical standard of AX-15836 (HY-101846). This product is intended for research and analytical applications. AX-15836 is a potent and selective ERK5 inhibitor with an IC50 of 8 nM.
    AX-15836 (Standard)
  • HY-101854R
    N6-(2-Phenylethyl)adenosine (Standard) 20125-39-7 98%
    N6-(2-Phenylethyl)adenosine (Standard) (N6-Phenethyladenosine (Standard)) is the analytical standard of N6-(2-Phenylethyl)adenosine (HY-101854). This product is intended for research and analytical applications. N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine), an adenosine derivative, is a potent adenosine receptors (AR) agonist with Ki values of 11.8 nM, 30.1 nM, 0.63 nM for rat A1AR, human A1AR and hA3AR, respectively.
    N6-(2-Phenylethyl)adenosine (Standard)
  • HY-101856R
    BMS-986142 (Standard) 1643368-58-4 98%
    BMS-986142 (Standard) is the analytical standard of BMS-986142 (HY-101856). This product is intended for research and analytical applications. BMS-986142 is a potent and highly selective reversible inhibitor of Bruton's tyrosine kinase (BTK) with an IC50 of 0.5 nM.
    BMS-986142 (Standard)
  • HY-101868R
    INF39 (Standard) 866028-26-4 98%
    INF39 (Standard) is the analytical standard of INF39 (HY-101868). This product is intended for research and analytical applications. INF39 is an irreversible and noncytotoxic NLRP3 inhibitor.
    INF39 (Standard)
  • HY-101872R
    GSK-872 (Standard) 1346546-69-7 98%
    GSK-872 (Standard) is the analytical standard of GSK-872 (HY-101872). This product is intended for research and analytical applications. GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.
    GSK-872 (Standard)
  • HY-101908R
    BMS CCR2 22 (Standard) 445479-97-0 98%
    BMS CCR2 22 (Standard) is the analytical standard of BMS CCR2 22 (HY-101908). This product is intended for research and analytical applications. BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM).
    BMS CCR2 22 (Standard)
  • HY-101913R
    IL-17A antagonist 1 (Standard) 2205034-18-8 98%
    IL-17A antagonist 1 (Standard) is the analytical standard of IL-17A antagonist 1 (HY-101913). This product is intended for research and analytical applications. IL-17A antagonist 1 (compound 1) is an IL-17A antagonist, with a Kd of 0.66 μM and an IC50 of 1.14 μM.
    IL-17A antagonist 1 (Standard)
  • HY-101915R
    IL-17A antagonist 3 (Standard) 2230780-65-9 98%
    IL-17A antagonist 3 (Standard) is the analytical standard of IL-17A antagonist 3 (HY-101915). This product is intended for research and analytical applications. IL-17A antagonist 3 is an IL-17A antagonist, compound 3.
    IL-17A antagonist 3 (Standard)
  • HY-101921R
    PI3Kδ-IN-1 (Standard) 1911564-39-0 98%
    PI3Kδ-IN-1 (Standard) is the analytical standard of PI3Kδ-IN-1 (HY-101921). This product is intended for research and analytical applications. PI3Kδ-IN-1 is a potent, selective, and efficacious PI3Kδ inhibitor with an IC50 of 1.7 nM.
    PI3Kδ-IN-1 (Standard)
  • HY-101922R
    IRAK4-IN-1 (Standard) 1820787-94-7 98%
    IRAK4-IN-1 (Standard) is the analytical standard of IRAK4-IN-1 (HY-101922). This product is intended for research and analytical applications. IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
    IRAK4-IN-1 (Standard)
Cat. No. Product Name / Synonyms Application Reactivity