Laflunimus (Standard)
Laflunimus (Standard) is the analytical standard of Laflunimus. This product is intended for research and analytical applications. Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726. Laflunimus is an orally active inhibitor of dihydroorotate dehydrogenase (DHODH). Laflunimus suppresses immunoglobulin (Ig) secretion, with IC50 values of 2.5 and 2 μM for IgM and IgG, respectively. Laflunimus also is a prostaglandin endoperoxide H synthase (PGHS) -1 and -2 inhibitor.
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- Pureté : 98%
- CAS No.: 147076-36-6
- Formule: C15H13F3N2O2
- Masse moléculaire:310.27
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
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HY-101813
LaflunimusImmunomodulator/DHODH Inhibitor -
HY-128787
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HY-135570
hDHODH-IN-3HsDHODH Inhibitor -
HY-139189
JNJ-74856665DHODH Inhibitor -
HY-137463
AG-636DHODH Inhibitor -
HY-108325
BrequinarDHODH Inhibitor -
HY-124593
PTC299VEGF Protein/DHODH Inhibitor -
HY-14908
VidofludimusDHODH Inhibitor -
HY-112645
BAY-2402234DHODH Inhibitor -
HY-108325R
Brequinar (Standard)DHODH Inhibitor -
HY-129239
FarudodstatDHODH Inhibitor -
HY-128068
DHODH-IN-17DHODH Inhibitor
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 147076-36-6
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Masse moléculaire 310.27
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Formule C15H13F3N2O2
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SMILES
O=C(NC1=CC=C(C(F)(F)F)C(C)=C1)/C(C#N)=C(C2CC2)\O
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Synonyms
HR325 (Standard)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Thomson TA, et al. In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine. Scand J Immunol. 2002 Jul;56(1):35-42. [Content Brief]
[2]. Curnock AP, et al. Potencies of leflunomide and HR325 as inhibitors of prostaglandin endoperoxide H synthase-1 and -2: comparison with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 1997 Jul;282(1):339-47. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Laflunimus (Standard) Related Classifications
HY-101813R Related Classifications
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