1. Neuronal Signaling
  2. Monoamine Oxidase
  3. Ro 41-1049 hydrochloride

Ro 41-1049 hydrochloride 

Cat. No.: HY-100027A Purity: 99.96%
Handling Instructions

Ro 41-1049 hydrochloride is a selective, reversible, orally-active MAO-A inhibitor.

For research use only. We do not sell to patients.

Ro 41-1049 hydrochloride Chemical Structure

Ro 41-1049 hydrochloride Chemical Structure

CAS No. : 127917-66-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg USD 288 In-stock
Estimated Time of Arrival: December 31
100 mg USD 480 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Ro 41-1049 hydrochloride is a selective, reversible, orally-active MAO-A inhibitor. Target: MAO in vivo: Ro 41-1049 is an inhibitor of the enzyme monoamine oxidase type A (MAO-A) to rats and monitored extracellular catecholamine levels in the corpus striatum before and after the intraperitoneal (IP) administration of a bolus of L-dopa. Acute administration of Ro 41-1049 (1-50 mg/kg IP) produced a dose-dependent decrease in basal levels of the dopamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and an increase in basal levels of dopamine. In rats treated with Ro 41-1049 (20 mg/kg IP), L-dopa administration (100 mg/kg IP) produced a greater increase in striatal levels of dopamine than it did in controls, while DOPAC and HVA formation was attenuated. We conclude that inhibition of central MAO-A activity promotes synaptic accumulation of dopamine following administration of pharmacological doses of L-dopa.

Molecular Weight

301.77

Formula

C₁₂H₁₃ClFN₃OS

CAS No.

127917-66-2

SMILES

O=C(C1=C(C2=CC=CC(F)=C2)SC=N1)NCCN.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (106.04 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3138 mL 16.5689 mL 33.1378 mL
5 mM 0.6628 mL 3.3138 mL 6.6276 mL
10 mM 0.3314 mL 1.6569 mL 3.3138 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Ro 41-1049 hydrochloride
Cat. No.:
HY-100027A
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