127917-66-2
Chemical Structure
Ro 41-1049 hydrochloride
- CAS No.: 127917-66-2
- Formula:C12H13ClFN3OS
- Molecular Weight:301.77
IUPAC Name: N-(2-aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide hydrochloride
InChIKey: RRNSPXUFTKJIEZ-UHFFFAOYSA-N
SMILES: O=C(C1=C(C2=CC=CC(F)=C2)SC=N1)NCCN.[H]Cl
Biological Activity: Ro 41-1049 hydrochloride is a highly selective, reversible MAO-A inhibitor. Ro 41-1049 hydrochloride effectively blocks the Quinpirole (HY-B1752)-induced increase in dopamine D2-like receptor density in the nucleus accumbens and alters the pattern of behavioral sensitization, shifting animals' responses from enhanced motor activity to immobile self-directed gaping behavior. Tritium-labeled Ro 41-1049 hydrochloride serves as a high-affinity radioligand, enabling accurate mapping of the distribution and abundance of MAO-A in the central nervous system, peripheral organs, and human brain via quantitative enzyme autoradiography. Ro 41-1049 hydrochloride can be used for basic research on depression and other related diseases[1][2][3].
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Ro 41-1049 hydrochloride | 99.57% | Ro 41-1049 hydrochloride is a highly selective, reversible MAO-A inhibitor. Ro 41-1049 hydrochloride effectively blocks the Quinpirole (HY-B1752)-induced increase in dopamine D2-like receptor density in the nucleus accumbens and alters the pattern of behavioral sensitization, shifting animals' responses from enhanced motor activity to immobile self-directed gaping behavior. Tritium-labeled Ro 41-1049 hydrochloride serves as a high-affinity radioligand, enabling accurate mapping of the distribution and abundance of MAO-A in the central nervous system, peripheral organs, and human brain via quantitative enzyme autoradiography. Ro 41-1049 hydrochloride can be used for basic research on depression and other related diseases. | ||||||||||||||||||||
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- [1]. Culver KE, et al.. Altered dopamine D2-like receptor binding in rats with behavioral sensitization to quinpirole: effects of pre-treatment with Ro 41-1049. European journal of pharmacology. 2008 Sep 11;592(1-3):67-72. [Content Brief]
- [2]. Saura J, et al. Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain[J]. Journal of Neuroscience, 1992, 12(5): 1977-1999.
- [3]. Da Prada M, et al. From moclobemide to Ro 19-6327 and Ro 41-1049: the development of a new class of reversible, selective MAO-A and MAO-B inhibitors[C]//Neurotransmitter Actions and Interactions: Proceedings of a Satellite Symposium of the 12th International Society for Neurochemistry Meeting, Algarve, Portugal, April 29–30, 1989. Vienna: Springer Vienna, 1990: 279-292.
Keywords
