2. Immunology/Inflammation
  3. COX
  4. SC58451

SC58451 is a potent and selective Cox-2 inhibitor.

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SC58451

SC58451 화학구조

CAS No. : 168433-84-9

사이즈 가격 재고 수량
1 mg 견적 받기 2 - 3 weeks 1-2 weeks 3 - 4 weeks 2-3 weeks
5 mg 견적 받기 2 - 3 weeks 1-2 weeks 3 - 4 weeks 2-3 weeks
10 mg   견적 받기  
50 mg   견적 받기  
Synthetic products have potential research and development risk.

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SC58451 Related Antibodies

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COX COX-1 COX-2 COX-3

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제품 설명

SC58451 is a potent and selective Cox-2 inhibitor.

IC50 & Target[1]

COX-2

 

Cellular Effect
Cell Line Type Value Description References
CHO IC50
0.0011 μM
Compound: SC-58451
Inhibition of PGE-2 production by arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 2
Inhibition of PGE-2 production by arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 2
10.1016/S0960-894X(96)00501-X
CHO IC50
0.14 μM
Compound: SC-58451
Inhibition of PGE-2 production in arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 1
Inhibition of PGE-2 production in arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 1
10.1016/S0960-894X(96)00501-X
Sf9 IC50
0.0075 μM
Compound: 10
Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by ELISA
Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by ELISA
[PMID: 30396033]
분자량

342.43

화학식

C20H19FO2S
CAS No.
SMILES

O=S(C1=CC=C(C(C2)=C(C3=CC=C(F)C=C3)CC42CC4)C=C1)(C)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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SC58451 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SC58451168433-84-9SC 58451SC-58451COXCyclooxygenaseInhibitorinhibitorinhibit

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상품명:
SC58451
Cat. No.:
HY-U00239
수량:
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