2. Autophagy NF-κB
  3. Autophagy Keap1-Nrf2
  4. Selenomethionine

Selenomethionine  (Synonyms: Seleno-DL-methionine; DL-Selenomethionine)

Cat. No.: HY-B1000 Purity: 99.86%
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Selenomethionine is a naturally occurring amino acid containing selenium that has oral activity and is a common natural food source. Selenomethionine has antitumor activity.

For research use only. We do not sell to patients.

CAS No. : 1464-42-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Solution
10 mM * 1 mL in Water In-stock
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100 mg In-stock
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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of Selenomethionine:

Selenomethionine Related Antibodies

Top Publications Citing Use of Products

    Selenomethionine purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 14;17(1):224.

    HT1080 and OS-RC-2 cells were treated with RSL3 (2 μM) or selenomethionine (SeleMet) (100 μM) as indicated for 4–6 h (n = 3). The lipid ROS levels were determined using flow cytometry (HT1080 and OS-RC-2 for 4 h)

    Selenomethionine purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 14;17(1):224.

    The protein levels of the GPX4 in OS-RC-2, HepG2, and HT1080 cells are cultured in ± CC (cystine) medium treated with Selenomethionine (SeleMet) were measured by western blot (WB).

    Selenomethionine purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Apr:70:103024.

    Kaplan‒Meier survival curves of mice pretreated with saline (control), SeMet (Selenomethionine), l-selenocystine, Se-methylselenocysteine, sodium selenite, and Se-rich cardamine enshiensis (0.75 mg/kg, by gavage, weekly) before DOX (20 mg/kg) administration and after the start of DOX (0.375 mg/kg, by gavage, weekly).

    Selenomethionine purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Apr:70:103024.

    A representative picric acid-Sirius red (PSR) staining image on day 28 after SeMet (Selenomethionine: 0.75 mg/kg) treatment.

    Selenomethionine purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Apr:70:103024.

    Cell viability was determined using the Cell-Quanti-Blue assay. H9C2 cells were cultured for 24 hours in medium with or without 100 nM SeMet (Selenomethionine) and then treated with DOX for 24 hours.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Selenomethionine is a naturally occurring amino acid containing selenium that has oral activity and is a common natural food source. Selenomethionine has antitumor activity[1][2][3].

    In Vitro

    Selenomethionine (50 μM, 12 h) decreases the hatchability and glutathione consumption of Japanese rice embryos, but does not affect selenium accumulation[1].
    Selenomethionine (45-135 μM, 24 h) inhibits the growth of MCF-7/S breast cancer, DU-145 prostate cancer cells and UAC-375 melanoma cells in a dose-dependent manner[2].
    Selenomethionine (25-500 μM, 24 h) inhibits TBHP-induced oxidative stress and mitochondrial division by activating the Nrf2 pathway, thereby inhibiting the apoptosis of nucleus pulposus cells (NPCs) and improving intervertebral disc degeneration (IDD)[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Selenomethionine Related Antibodies

    Western Blot Analysis[3]

    Cell Line: NPCs
    Concentration: 25, 50, 75, 100, 150, 300, and 500 μM
    Incubation Time: 24 h
    Result: Downregulated of cleaved-caspase 9, cleaved-caspase 3 and upregulated of Bax and Bcl-2.
    Reduced the expression levels of DRP1, MFF, and Fis1, upregulated the expression levels of OPA1, Mfn1, and Mfn2.
    In Vivo

    Selenomethionine (2 mg/kg/day, gavage for 4 weeks) can improve the degenerative performance in the acupuncturally-induced rat IDD model[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: IDD Rat Model[3]
    Dosage: 2mg/kg/day
    Administration: i.g
    Result: Reduced NP size, collapsed disc height, significant loss of cells, and dense ECM.
    Decreased the levels of Nrf2 and collagen II amd increased the expression level of MMP13.
    Clinical Trial
    Molecular Weight

    196.11

    Formula

    C5H11NO2Se
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O)C(N)CC[Se]C
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : 12.5 mg/mL (63.74 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.0992 mL 25.4962 mL 50.9923 mL
    5 mM 1.0198 mL 5.0992 mL 10.1985 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 10 mg/mL (50.99 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.86%

    SDS (729 KB)

    COA (244 KB) RP-HPLC (246 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 5.0992 mL 25.4962 mL 50.9923 mL 127.4808 mL
    5 mM 1.0198 mL 5.0992 mL 10.1985 mL 25.4962 mL
    10 mM 0.5099 mL 2.5496 mL 5.0992 mL 12.7481 mL
    15 mM 0.3399 mL 1.6997 mL 3.3995 mL 8.4987 mL
    20 mM 0.2550 mL 1.2748 mL 2.5496 mL 6.3740 mL
    25 mM 0.2040 mL 1.0198 mL 2.0397 mL 5.0992 mL
    30 mM 0.1700 mL 0.8499 mL 1.6997 mL 4.2494 mL
    40 mM 0.1275 mL 0.6374 mL 1.2748 mL 3.1870 mL
    50 mM 0.1020 mL 0.5099 mL 1.0198 mL 2.5496 mL
    60 mM 0.0850 mL 0.4249 mL 0.8499 mL 2.1247 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Selenomethionine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Selenomethionine1464-42-2Seleno-DL-methionine DL-SelenomethionineAutophagyKeap1-Nrf2Inhibitorinhibitorinhibit

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