2. Others PI3K/Akt/mTOR Membrane Transporter/Ion Channel
  3. Drug Derivative Akt P2X Receptor
  4. TB500

TB500 is a synthetic version of an active region of thymosin β4. TB500 exhibits anti-fibrotic and wound healing activities by inhibiting the Akt signaling pathway and binding to actin. TB500 is claimed to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation.

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TB500

TB500 構造式

CAS 番号 : 885340-08-9

容量 価格（税別） 在庫状況 数量
5 mg $70 在庫あり
10 mg $112 在庫あり
25 mg $200 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

TB500 関連抗体

Top Publications Citing Use of Products

Akt アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Akt Akt1 Akt2 Akt3

P2X Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
P2X1 Receptor P2X2 Receptor P2X3 Receptor P2X4 Receptor P2X7 Receptor

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製品説明

TB500 is a synthetic version of an active region of thymosin β4. TB500 exhibits anti-fibrotic and wound healing activities by inhibiting the Akt signaling pathway and binding to actin. TB500 is claimed to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation[1][2][3].

体外実験

TB500 exhibits tissue repairing and regenerative activities through its active ingredient Ac-Tβ417-23. Ac-Tβ417-23 prevents apoptosis, promotes cell survival and angiogenesis, stimulates T cell proliferation, exhibiting immunomodulatory activity[2].
TB500 (15-25 μg/mL, 2 days) promotes cell migration and wound healing by enhancing ATP-induced increase in intracellular calcium ions and activating purinergic P2 receptors[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TB500 関連抗体

Cell Migration Assay [3]

Cell Line: PAM212
Concentration: 15-25 μg/mL
Incubation Time: 2 days
Result: Promoted cell migration.
体内実験

TB500 (10 mg/dose, single dose) can be used as doping agent in horse and greyhound racing[2].
TB500 (15 μg/30 μL, topical administration, once daily for 10 days) promotes wound healing, and exhibits good tissue repair effects in BALB/c mouse models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mouse skin wound models[3]
Dosage: 15 μg/30 μL
Administration: 15 μg/30 μL, topical administration, once daily for 10 days
Result: Accelerated wound healing.
臨床実験
分子量

889.01

分子式

C38H68N10O14
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

N-Acetyl-Leu-Lys-Lys-Thr-Glu-Thr-Gln
Sequence Shortening

Ac-LKKTETQ
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

polypeptide, sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light, under nitrogen)
溶剤 & 溶解度
体外: 

H2O : ≥ 200 mg/mL (224.97 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1248 mL 5.6242 mL 11.2485 mL
5 mM 0.2250 mL 1.1248 mL 2.2497 mL
10 mM 0.1125 mL 0.5624 mL 1.1248 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1248 mL 5.6242 mL 11.2485 mL 28.1212 mL
5 mM 0.2250 mL 1.1248 mL 2.2497 mL 5.6242 mL
10 mM 0.1125 mL 0.5624 mL 1.1248 mL 2.8121 mL
15 mM 0.0750 mL 0.3749 mL 0.7499 mL 1.8747 mL
20 mM 0.0562 mL 0.2812 mL 0.5624 mL 1.4061 mL
25 mM 0.0450 mL 0.2250 mL 0.4499 mL 1.1248 mL
30 mM 0.0375 mL 0.1875 mL 0.3749 mL 0.9374 mL
40 mM 0.0281 mL 0.1406 mL 0.2812 mL 0.7030 mL
50 mM 0.0225 mL 0.1125 mL 0.2250 mL 0.5624 mL
60 mM 0.0187 mL 0.0937 mL 0.1875 mL 0.4687 mL
80 mM 0.0141 mL 0.0703 mL 0.1406 mL 0.3515 mL
100 mM 0.0112 mL 0.0562 mL 0.1125 mL 0.2812 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TB500 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TB500885340-08-9TB 500TB-500Drug DerivativeAktP2X ReceptorDrug derivativePKBProtein kinase BP2XRsthymosin β 4cell differentiationkeratinocyte migrationcollagen depositioninflammationPAM212Inhibitorinhibitorinhibit

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製品名:
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製品番号:
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