1. Anti-infection
  2. Bacterial
  3. TBAJ-587

TBAJ-587 

Cat. No.: HY-111747 Purity: 98.03%
Handling Instructions

TBAJ-587, a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively. TBAJ-587 inhibits hERG channel minimally, attenuates inhibition of the cardiac potassium channel protein coded by the hERG, which is important for cardiac repolarization.

For research use only. We do not sell to patients.

TBAJ-587 Chemical Structure

TBAJ-587 Chemical Structure

CAS No. : 2252316-16-6

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 473 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

TBAJ-587, a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively. TBAJ-587 inhibits hERG channel minimally, attenuates inhibition of the cardiac potassium channel protein coded by the hERG, which is important for cardiac repolarization[1].

IC50 & Target

Anti-tuberculosis[1]

In Vitro

Bedaquiline is a drug of the diarylquinoline class that has proven to be clinically effective against drug-resistant tuberculosis, but has a cardiac liability due to its potent inhibition of the cardiac potassium channel protein hERG. TBAJ-587, an analogue of Bedaquiline, demonstrates more potent anti-tubercular activity, with greatly attenuated hERG blockade. TBAJ-587 inhibits hERG channel with an IC50 of 13 μM[1].

Molecular Weight

614.50

Formula

C₃₀H₃₃BrFN₃O₅

CAS No.

2252316-16-6

SMILES

COC1=C(F)C([[email protected]](C2=CC3=CC(Br)=CC=C3N=C2OC)[[email protected]](O)(C4=CC(OC)=NC(OC)=C4)CCN(C)C)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 43.33 mg/mL (70.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6273 mL 8.1367 mL 16.2734 mL
5 mM 0.3255 mL 1.6273 mL 3.2547 mL
10 mM 0.1627 mL 0.8137 mL 1.6273 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (3.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (3.53 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (3.53 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TBAJ-587TBAJ587TBAJ 587BacterialInhibitorinhibitorinhibit

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Product Name:
TBAJ-587
Cat. No.:
HY-111747
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