1. Anti-infection
  2. Bacterial

TBAJ-587 

Cat. No.: HY-111747
Handling Instructions

TBAJ-587, a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively. TBAJ-587 inhibits hERG channel minimally, attenuates inhibition of the cardiac potassium channel protein coded by the hERG, which is important for cardiac repolarization.

For research use only. We do not sell to patients.

TBAJ-587 Chemical Structure

TBAJ-587 Chemical Structure

CAS No. : 2252316-16-6

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

TBAJ-587, a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively. TBAJ-587 inhibits hERG channel minimally, attenuates inhibition of the cardiac potassium channel protein coded by the hERG, which is important for cardiac repolarization[1].

IC50 & Target

Anti-tuberculosis[1]

In Vitro

Bedaquiline is a drug of the diarylquinoline class that has proven to be clinically effective against drug-resistant tuberculosis, but has a cardiac liability due to its potent inhibition of the cardiac potassium channel protein hERG. TBAJ-587, an analogue of Bedaquiline, demonstrates more potent anti-tubercular activity, with greatly attenuated hERG blockade. TBAJ-587 inhibits hERG channel with an IC50 of 13 μM[1].

References
Molecular Weight

614.50

Formula

C₃₀H₃₃BrFN₃O₅

CAS No.

2252316-16-6

SMILES

COC1=C(F)C([[email protected]](C2=CC3=CC(Br)=CC=C3N=C2OC)[[email protected]](O)(C4=CC(OC)=NC(OC)=C4)CCN(C)C)=CC=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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TBAJ-587
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HY-111747
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TBAJ-587

Cat. No.: HY-111747