1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Thiarabine

Thiarabine (Synonyms: OSI-7836)

Cat. No.: HY-16496
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Thiarabine (OSI-7836) shows potent anti-tumor activity and inhibition of DNA synthesis.

For research use only. We do not sell to patients.

Thiarabine Chemical Structure

Thiarabine Chemical Structure

CAS No. : 26599-17-7

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Description

Thiarabine (OSI-7836) shows potent anti-tumor activity and inhibition of DNA synthesis.

IC50 & Target

DNA synthesis[1].

In Vivo

Thiarabine has demonstrated exceptional antitumor activity against numerous human tumor xenografts in mice, being superior to gemcitabine, clofarabine, or cytarabine. Unlike cytarabine, Thiarabine demonstrates excellent activity against solid tumor xenografts, suggesting that this agent has the kind of robust activity in animal models that leads to clinical utility. Thiarabine is effective orally (bioavailability of approximately 16%) and with once per day dosing: Two characteristics that distinguish it from cytarabine. Although both the structure and basic mechanism of action of Thiarabine are similar to that of cytarabine, there are many quantitative differences in the biochemical pharmacology of these two agents that can explain the superior antitumor activity of Thiarabine. Two important attributes are the long retention time of the 5'-triphosphate of thiarabine in tumor cells and its potent inhibition of DNA synthesis. The biochemical pharmacology of Thiarabine is also different from that of gemcitabine[1].

Clinical Trial
Molecular Weight

259.28

Formula

C₉H₁₃N₃O₄S

CAS No.

26599-17-7

SMILES
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Thiarabine
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