1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. 5-HT Receptor
  4. 5-HT2 Receptor Isoform
  5. 5-HT2 Receptor Modulator

5-HT2 Receptor Modulator

5-HT2 Receptor Modulators (20):

Cat. No. Product Name Effect Purity
  • HY-14539
    Clozapine
    Modulator 99.99%
    Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia.
  • HY-15780
    Brexpiprazole
    Modulator 99.64%
    Brexpiprazole (OPC-34712), an atypical orally active antipsychotic drug, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively.
  • HY-N0049
    Nuciferine
    Modulator 99.46%
    Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
  • HY-B0731A
    Perospirone
    Modulator 99.43%
    Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM).
  • HY-105285
    Piromelatine
    Modulator 99.21%
    Piromelatine (Neu-P11) is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist.
  • HY-A0095
    Flibanserin
    Modulator 99.10%
    Flibanserin (BIMT-17; BIMT-17BS) is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively.
  • HY-32329
    Setiptiline
    Modulator 98.04%
    Setiptiline (Org-8282) is a serotonin receptor antagonist.
  • HY-101094
    Ocaperidone
    Modulator 99.63%
    Ocaperidone is an effective antipsychotic agent, acting as a potent 5-HT2 and dopamine D2 antagonist, and a 5-HT1A agonist, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1 and a2-adrenergic receptor, respectively, and a pEC50 and pKi of 7.60 and 8.08 for h5-HT1A.
  • HY-111385
    UNC9994 hydrochloride
    Modulator 98.83%
    UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling.
  • HY-16687A
    Eltoprazine hydrochloride
    Modulator 99.85%
    Eltoprazine hydrochloride (DU 28853 hydrochloride) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.
  • HY-109112
    Brilaroxazine
    Modulator 98.29%
    Brilaroxazine (RP5603) is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator.
  • HY-100290
    5-HT1A modulator 1
    Modulator
    5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1 and dopamine D2 receptor with IC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively.
  • HY-16687
    Eltoprazine
    Modulator
    Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.
  • HY-W011040
    LY320135
    Modulator
    LY320135 is a potent and selective antagonist of CB1 receptor, with a Ki of 141 nM.
  • HY-15780A
    Brexpiprazole hydrochloride
    Modulator
    Brexpiprazole (OPC-34712) hydrochloride, an atypical orally active antipsychotic drug, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively.
  • HY-133152S
    Brexpiprazole S-oxide-d8
    Modulator
    Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide.
  • HY-A0095A
    Flibanserin hydrochloride
    Modulator
    Flibanserin (BIMT-17; BIMT-17BS) hydrochloride is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively.
  • HY-B0731
    Perospirone hydrochloride
    Modulator
    Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM).
  • HY-117829
    UNC9994
    Modulator
    UNC9994, an analog of Aripiprazole, is a functionally selective β-arrestin-biased dopamine D2 receptor (D2R) agonist with EC50 <10 nM for β-arrestin-2 recruitment to D2 receptors.
  • HY-133152
    Brexpiprazole S-oxide
    Modulator
    Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4).