2. Signalwege
  3. Metabolic Enzyme/Protease
  4. Aldehyde Dehydrogenase (ALDH)
  5. ALDH2 Isoform

ALDH2

ALDH2 (aldehyde dehydrogenase 2) is a mitochondrial NAD(P)+-dependent enzyme that catalyzes the irreversible oxidation of acetaldehyde and other reactive aldehydes into their corresponding carboxylic acids, thereby maintaining cellular detoxification and redox homeostasis[1][2]. Mechanistically, ALDH2 participates in the major oxidative pathway of alcohol metabolism and also eliminates lipid peroxidation-derived aldehydes, including 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA), which accumulate during oxidative stress and mitochondrial dysfunction[3][4]. Through detoxification of these highly reactive aldehydes, ALDH2 limits protein modification, oxidative injury, and disruption of intracellular signaling pathways associated with cardiovascular and metabolic disorders[3][4]. In disease models, reduced ALDH2 activity has been linked to myocardial injury, heart failure, diabetes, neurodegenerative diseases, stroke, and cancer, highlighting its broad role in stress-response mechanisms and tissue protection[4][5]. Compared with related ALDH isoforms, ALDH2 is distinguished by its mitochondrial localization and high catalytic efficiency toward acetaldehyde, whereas ALDH1A family members primarily regulate retinoic acid biosynthesis and ALDH1A1 or ALDH3A1 contribute to ocular protection and other tissue-specific functions[1][2]. A common inactive variant, ALDH22, markedly reduces enzymatic activity and promotes acetaldehyde accumulation, providing a widely used genetic model for studying aldehyde toxicity, oxidative stress, and disease susceptibility in East Asian populations[1][6]. For experimental applications, both ALDH2-selective activators and inhibitors have been developed to investigate isoform-specific functions, mitochondrial aldehyde metabolism, and therapeutic modulation of oxidative stress pathways[1][5].

ALDH2 Verwandte Produkte (11):

Art. -Nr. Produktname Wirkung Reinheit
  • HY-113466
    4-Hydroxynonenal
    		Inhibitor 99.73%
    4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria.
  • HY-18936
    Alda-1
    		Agonist 99.99%
    Alda-1 is a potent and selective ALDH2 agonist, which activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2.
  • HY-19801
    CVT-10216
    		Inhibitor 99.87%
    CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects.
  • HY-B0364A
    Dyclonine hydrochloride
    		Inhibitor 99.30%
    Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local agent that can suppress or relieve pain. that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain.
  • HY-76006
    3-Hydroxybenzaldehyde
    		99.93%
    3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA) (HY-N0295). 3-Hydroxybenzaldehyde, produced by 3-hydroxybenzyl-alcohol dehydrogenase, is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans. 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo. 3-Hydroxybenzaldehyde is proming for research of atherosclerosis.
  • HY-182636
    MT16-001
    MT16-001 is a cell-permeable UCHL1 inhibitor with an IC50 value of 580 nM. MT16-001 also exhibits considerable inhibitory activity against USP30, and shows selectivity for other UCH family deubiquitinases (DUBs) as well as the broader proteome. MT16-001 binds covalently to the cysteine residue at the active site of UCHL1, and forms covalent interactions with ALDH2, ALDH9A1 and GATD3A in intact cells. Meanwhile, as a cytotoxic agent, it displays a steep dose-response curve in human embryonic kidney cells. MT16-001 can be used for research on various cancers, liver fibrosis and pulmonary fibrosis.
  • HY-146683
    KS106
    		Inhibitor 99.87%
    KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase.
  • HY-113466S
    4-Hydroxynonenal-d3
    		Inhibitor 99.0%
    4-Hydroxynonenal-d3 is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria.
  • HY-176716
    ALDH2 activator 1
    		Agonist 98.88%
    ALDH2 activator 1 (Compound Z17) is an allosteric aldehyde dehydrogenase 2 (ALDH2) agonist. ALDH2 activator 1 enhances cardiac function and reduces myocardial necrosis in a mouse model of myocardial ischemia-reperfusion. ALDH2 activator 1 is promising for research of cardiovascular diseases such as myocardial infarction (MI).
  • HY-126241
    RV01
    		Inhibitor 98.06%
    RV01 is an analogue of resveratrol, inhibits DNA damage, reduces acetaldehyde dehydrogenase 2 (ALDH2) mRNA expression induced by ethanol, and exhibits hydroxyl radical scavenging activity. RV01 decreases iNOS expression, with anti-neuroinflammatory activity.
  • HY-148617
    ALDH2 modulator 1
    		Modulator
    ALDH2 modulator 1 is a potent and orally active aldehyde dehydrogenase-2 (ALDH2) modulator. ALDH2 modulator 1 reduces blood alcohol levels in mice.
Art. -Nr. Produktname / Synonyms Application Reactivity