ALDH2 modulator 1
Based on 1 Customer Validation
ALDH2 modulator 1 is a potent and orally active aldehyde dehydrogenase-2 (ALDH2) modulator. ALDH2 modulator 1 reduces blood alcohol levels in mice.
For research use only. We do not sell to patients.
- Purity: 99.25%
- CAS No.: 1629615-99-1
- Formula: C18H18ClFN2O3
- Molecular Weight:364.80
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
ALDH2 |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-9 weeks, 20-22 g, Male C57BL6 mice (treated with PO 5/kg of EtOH)[1]
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Dosage:40, 60 mg/kg for p.o. or 10 mg/kg for i.v.
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Administration:P.o. or i.v.
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Result:Reduced blood alcohol levels in mice treated with PO 5 g/kg of EtOH.
Chemical Information
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CAS No. 1629615-99-1
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Appearance Solid
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Molecular Weight 364.80
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Formula C18H18ClFN2O3
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Color White to off-white
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SMILES
O=C(C1=C(C=CN=C1OCC2CC2)Cl)NCC3=CC=C(C(F)=C3)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (137.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.7412 mL | 13.7061 mL | 27.4123 mL | 68.5307 mL |
| 5 mM | 0.5482 mL | 2.7412 mL | 5.4825 mL | 13.7061 mL | |
| 10 mM | 0.2741 mL | 1.3706 mL | 2.7412 mL | 6.8531 mL | |
| 15 mM | 0.1827 mL | 0.9137 mL | 1.8275 mL | 4.5687 mL | |
| 20 mM | 0.1371 mL | 0.6853 mL | 1.3706 mL | 3.4265 mL | |
| 25 mM | 0.1096 mL | 0.5482 mL | 1.0965 mL | 2.7412 mL | |
| 30 mM | 0.0914 mL | 0.4569 mL | 0.9137 mL | 2.2844 mL | |
| 40 mM | 0.0685 mL | 0.3427 mL | 0.6853 mL | 1.7133 mL | |
| 50 mM | 0.0548 mL | 0.2741 mL | 0.5482 mL | 1.3706 mL | |
| 60 mM | 0.0457 mL | 0.2284 mL | 0.4569 mL | 1.1422 mL | |
| 80 mM | 0.0343 mL | 0.1713 mL | 0.3427 mL | 0.8566 mL | |
| 100 mM | 0.0274 mL | 0.1371 mL | 0.2741 mL | 0.6853 mL |
ALDH2 modulator 1 Related Classifications
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