KS106
Based on 1 Customer Validation
KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 2408477-50-7
- Formula: C18H15BrF3N3O2S
- Molecular Weight:474.29
-
Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Apoptosis Compound Library
HY-L003
-
Metabolism/Protease Compound Library
HY-L012
-
Anti-Cancer Compound Library
HY-L025
-
Covalent Screening Library
HY-L036
-
Ferroptosis Compound Library
HY-L051
-
Glutamine Metabolism Compound Library
HY-L064
-
Anti-Cancer Metabolism Compound Library
HY-L083
-
Cancer Stem Cells Compound Library
HY-L135
-
Metabolic Enzyme Compound Library
HY-L146
-
Cell Death Library
HY-L162
-
Multi-Target Compound Library
HY-L176
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Covalent Screening Library Plus
HY-L036P
-
Bioactive Compound Library
HY-L001
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
|
ALDH2 2137 nM (IC50) |
ALDH1A1 334 nM (IC50) |
ALDH3A1 360 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
5.7 μM
Compound: 3h; KS106
|
Antiproliferative activity against human HCT116 cells measured after 72 hrs by MTS assay
Antiproliferative activity against human HCT116 cells measured after 72 hrs by MTS assay
|
[PMID: 31887569] |
| HT-29 | IC50 |
4.9 μM
Compound: 3h; KS106
|
Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTS assay
Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTS assay
|
[PMID: 31887569] |
| MM1.S | IC50 |
2.2 μM
Compound: 3h; KS106
|
Antiproliferative activity against human MM.1S cells measured after 72 hrs by MTS assay
Antiproliferative activity against human MM.1S cells measured after 72 hrs by MTS assay
|
[PMID: 31887569] |
| NCI-H929 | IC50 |
1.5 μM
Compound: 3h; KS106
|
Antiproliferative activity against human NCIH929 cells measured after 72 hrs by MTS assay
Antiproliferative activity against human NCIH929 cells measured after 72 hrs by MTS assay
|
[PMID: 31887569] |
| RPMI-8226 | IC50 |
1.6 μM
Compound: 3h; KS106
|
Antiproliferative activity against human RPMI8226 cells measured after 72 hrs by MTS assay
Antiproliferative activity against human RPMI8226 cells measured after 72 hrs by MTS assay
|
[PMID: 31887569] |
| U-266 | IC50 |
2.6 μM
Compound: 3h; KS106
|
Antiproliferative activity against human U266 cells measured after 72 hrs by MTS assay
Antiproliferative activity against human U266 cells measured after 72 hrs by MTS assay
|
[PMID: 31887569] |
| UACC-903 | IC50 |
5.7 μM
Compound: 3h; KS106
|
Antiproliferative activity against human UACC 903 cells measured after 72 hrs by MTS assay
Antiproliferative activity against human UACC 903 cells measured after 72 hrs by MTS assay
|
[PMID: 31887569] |
KS106 (compound 3h) (0-100 µM; 72 h) shows anti-proliferative activity with IC50s of 5.7, 5.7, 5.7, 4.9, 1.5, 2.6, 1.6, 1.7, 2.2, 20.7 µM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively[1].
KS106 (5 µM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2408477-50-7
-
Appearance Solid
-
Molecular Weight 474.29
-
Formula C18H15BrF3N3O2S
-
Color Light yellow to yellow
-
SMILES
N=C(SCC1=CC=C(C=C1)CN2C(C(C3=CC(C(F)(F)F)=CC=C32)=O)=O)N.Br
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (210.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1084 mL | 10.5421 mL | 21.0841 mL | 52.7104 mL |
| 5 mM | 0.4217 mL | 2.1084 mL | 4.2168 mL | 10.5421 mL | |
| 10 mM | 0.2108 mL | 1.0542 mL | 2.1084 mL | 5.2710 mL | |
| 15 mM | 0.1406 mL | 0.7028 mL | 1.4056 mL | 3.5140 mL | |
| 20 mM | 0.1054 mL | 0.5271 mL | 1.0542 mL | 2.6355 mL | |
| 25 mM | 0.0843 mL | 0.4217 mL | 0.8434 mL | 2.1084 mL | |
| 30 mM | 0.0703 mL | 0.3514 mL | 0.7028 mL | 1.7570 mL | |
| 40 mM | 0.0527 mL | 0.2636 mL | 0.5271 mL | 1.3178 mL | |
| 50 mM | 0.0422 mL | 0.2108 mL | 0.4217 mL | 1.0542 mL | |
| 60 mM | 0.0351 mL | 0.1757 mL | 0.3514 mL | 0.8785 mL | |
| 80 mM | 0.0264 mL | 0.1318 mL | 0.2636 mL | 0.6589 mL | |
| 100 mM | 0.0211 mL | 0.1054 mL | 0.2108 mL | 0.5271 mL |
Powered by Bioz