2408477-50-7
Chemical Structure
KS106
- CAS No.: 2408477-50-7
- Formula:C18H15BrF3N3O2S
- Molecular Weight:474.29
IUPAC Name: 4-((2,3-dioxo-5-(trifluoromethyl)indolin-1-yl)methyl)benzyl carbamimidothioate hydrobromide
InChIKey: AHVSKNDQJSDEMD-UHFFFAOYSA-N
SMILES: N=C(SCC1=CC=C(C=C1)CN2C(C(C3=CC(C(F)(F)F)=CC=C32)=O)=O)N.Br
Biological Activity: KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KS106 | 99.87% | KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase. | ||||||||||||||||||||
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