1. GPCR/G Protein Neuronal Signaling
  2. mAChR
  3. VU0119498

VU0119498 is a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM), with EC50s of 6.04, 6.38, and 4.08 µM, respectively. VU0119498 has antidiabetic activity.

For research use only. We do not sell to patients.

VU0119498 Chemical Structure

VU0119498 Chemical Structure

CAS No. : 79183-37-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 66 In-stock
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Solid
5 mg USD 38 In-stock
10 mg USD 60 In-stock
25 mg USD 110 In-stock
50 mg USD 160 In-stock
100 mg USD 240 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

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Description

VU0119498 is a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM), with EC50s of 6.04, 6.38, and 4.08 µM, respectively. VU0119498 has antidiabetic activity[1][2][3].

In Vitro

VU0119498 (0.01-30 μM; 150 s) potentiates Ach responses in M1, M3, and M5-expressing CHO cells, with EC50s of 6.04, 6.38, and 4.08 µM, respectively[1].
VU0119498 (3-20 μM) augments ACh-mediated increasing in insulin secretion and intracellular calcium levels in MIN6-K8 cells[3].
VU0119498 (20 μM; 90 min) enhances ACh-induced insulin release in mouse and human pancreatic islets[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VU0119498 (0.1-2 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in mice in a β-cell M3R-dependent fashion[3].
VU0119498 (0.5 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in obese, glucose-intolerant mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male WT mice (12 weeks)[3]
Dosage: 0.1, 0.5, 2 mg/kg
Administration: A single i.p.
Result: Caused a significant improvement in glucose tolerance at the dose of 0.5 mg/kg.
Significantly augmented GSIS at the dose of 0.5 mg/kg.
Molecular Weight

316.15

Formula

C15H10BrNO2

CAS No.
Appearance

Solid

Color

Orange to red

SMILES

O=C1N(C2=C(C1=O)C=CC=C2)CC3=CC=C(C=C3)Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (158.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1631 mL 15.8153 mL 31.6306 mL
5 mM 0.6326 mL 3.1631 mL 6.3261 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.52%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1631 mL 15.8153 mL 31.6306 mL 79.0764 mL
5 mM 0.6326 mL 3.1631 mL 6.3261 mL 15.8153 mL
10 mM 0.3163 mL 1.5815 mL 3.1631 mL 7.9076 mL
15 mM 0.2109 mL 1.0544 mL 2.1087 mL 5.2718 mL
20 mM 0.1582 mL 0.7908 mL 1.5815 mL 3.9538 mL
25 mM 0.1265 mL 0.6326 mL 1.2652 mL 3.1631 mL
30 mM 0.1054 mL 0.5272 mL 1.0544 mL 2.6359 mL
40 mM 0.0791 mL 0.3954 mL 0.7908 mL 1.9769 mL
50 mM 0.0633 mL 0.3163 mL 0.6326 mL 1.5815 mL
60 mM 0.0527 mL 0.2636 mL 0.5272 mL 1.3179 mL
80 mM 0.0395 mL 0.1977 mL 0.3954 mL 0.9885 mL
100 mM 0.0316 mL 0.1582 mL 0.3163 mL 0.7908 mL
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VU0119498 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
VU0119498
Cat. No.:
HY-114933
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