1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR

VU 0238429 

Cat. No.: HY-12157 Purity: 99.96%
Handling Instructions

VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM.

For research use only. We do not sell to patients.

VU 0238429 Chemical Structure

VU 0238429 Chemical Structure

CAS No. : 1160247-92-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
25 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg USD 390 In-stock
Estimated Time of Arrival: December 31
100 mg USD 690 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM.

IC50 & Target

EC50: 1.16 μM (mAChR5)[1].

In Vitro

VU 0238429 is positive allosteric modulator of mAChR5 (M5), with an EC50 of 1.16 μM, >30-fold selectivity versus M1 and M3, with no M2 or M4 potentiator activity[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8467 mL 14.2337 mL 28.4673 mL
5 mM 0.5693 mL 2.8467 mL 5.6935 mL
10 mM 0.2847 mL 1.4234 mL 2.8467 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

351.28

Formula

C₁₇H₁₂F₃NO₄

CAS No.

1160247-92-6

SMILES

O=C1N(CC2=CC=C(OC)C=C2)C3=C(C=C(OC(F)(F)F)C=C3)C1=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
VU 0238429
Cat. No.:
HY-12157
Quantity:

VU 0238429

Cat. No.: HY-12157