1. Metabolic Enzyme/Protease
    Apoptosis
  2. Aldehyde Dehydrogenase (ALDH)
    Apoptosis
  3. KS100

KS100 

Cat. No.: HY-146682
Handling Instructions

KS100 is a potent ALDH inhibitor with IC50s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase.

For research use only. We do not sell to patients.

KS100 Chemical Structure

KS100 Chemical Structure

CAS No. : 2408477-54-1

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Description

KS100 is a potent ALDH inhibitor with IC50s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase[1].

IC50 & Target

IC50: 230 nM (ALDH1A1); 1542 nM (ALDH2); 193 nM (ALDH3A1)[1]

In Vitro

KS100 (compound 3j) (0-100 µM; 72 h) shows anti-proliferative activity with IC50s of 3.7, 2.1, 2.9, 2.5, 0.3, 1.0, 1.2, 1.3, 2.1, 9.8 µM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively[1].
KS100 (5 µM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: HCT116, HT29 cells
Concentration: 5 µM
Incubation Time: 24 h
Result: Induced cell apoptosis.

Apoptosis Analysis[1]

Cell Line: HCT116 cells
Concentration: 5 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at G2/M phase.
Molecular Weight

564.09

Formula

C17H14Br3N3O2S

CAS No.
SMILES

N=C(SCC1=CC=C(C=C1)CN2C(C(C3=CC(Br)=CC(Br)=C32)=O)=O)N.Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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KS100
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HY-146682
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