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Art. -Nr.: HY-143470

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SARS-CoV-2-IN-18

SARS-CoV-2-IN-18 (Compound 26) is a potent SARS-CoV-2 3C-like protease inhibitor with an IC₅₀ of 45 nM.

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CAS. Nr.: 184904-82-3
Formel: C₂₀H₁₄N₂O₃
Molecular Weight:330.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

SARS-CoV-2-IN-18 Chemical Structure

CAS. Nr.: 184904-82-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

SARS-CoV-2-IN-18 (Compound 26) is a potent SARS-CoV-2 3C-like protease inhibitor with an IC₅₀ of 45 nM^[1].

IC₅₀ & Target

IC₅₀: 45 nM (SARS-CoV-2 3C-like protease)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	>10 μM Compound: 18	Compound was tested for the antiviral activity against Human Rhinovirus -14(HRV-14) in HeLa cells Compound was tested for the antiviral activity against Human Rhinovirus -14(HRV-14) in HeLa cells	[PMID: 8978838]
Vero C1008	CC₅₀	<2.2 μM Compound: L-26; 6	Cytotoxicity against African green monkey Vero E6 assessed as inhibition of cell growth incubated for 26 hrs Cytotoxicity against African green monkey Vero E6 assessed as inhibition of cell growth incubated for 26 hrs	[PMID: 37859715]

Chemical Information

CAS. Nr. 184904-82-3
Molecular Weight 330.34
Formel C₂₀H₁₄N₂O₃
SMILES

O=C(C1=CC2=C(N(CC3=CC=C4C=CC=CC4=C3)C(C2=O)=O)C=C1)N
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pei Liu, et al. Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds. Eur J Med Chem. 2020 Nov 15;206:112702. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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