2. Signaling Pathways
  3. Neuronal Signaling
  4. Amyloid-β

Amyloid-β

β-amyloid peptide; Aβ; Abeta

Amyloid-β

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Amyloid-β (Aβ) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of theamyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is being cut by certain enzymes to yield Aβ. Amyloid-β molecules can aggregate to form flexible soluble oligomers which may exist in several forms. Amyloid-β peptide is due to overproduction of Aβ and/or the failure of clearance mechanisms. Amyloid-β self-aggregates into oligomers, which can be of various sizes, and forms diffuse and neuritic plaques in the parenchyma and blood vessels. Amyloid-β oligomers and plaques are potent synaptotoxins, block proteasome function, inhibit mitochondrial activity, alter intracellular Ca2+levels and stimulate inflammatory processes. Loss of the normal physiological functions of Aβ is also thought to contribute to neuronal dysfunction.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1850
    β-Amyloid (1-20)
    		99.67%
    β-Amyloid (1-20) consists of amino acids 1 to 20 of beta amyloid protein.
    β-Amyloid (1-20)
  • HY-P4886
    Amyloid β-Protein (3-42)
    		99.20%
    Amyloid β-Protein (3-42) is the precursor of Pyr peptide. Pyroglutamate-modified Aβ (pEAβ) (3-42) is the core of the amyloid template block in Alzheimer's disease. pEAβ(3-42) accelerated the aggregation of Aβ(1-42), while Aβ(1-42) significantly slowed the primary and secondary nucleation of pEAβ(3-42).
    Amyloid β-Protein (3-42)
  • HY-P991702
    Merinetug
    		Inhibitor
    Merinetug is a humanized IgG1κ antibody targeting Amyloid beta/Aβ. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001).
    Merinetug
  • HY-156049
    MG-H1
    MG-H1 is a receptor of advanced glycation end products (RAGE) ligand with a Kd of 4.12 nM. MG-H1 can bind to human umbilical vein endothelial cell. MG-H1 can be used for research of diabetes.
    MG-H1
  • HY-P5333A
    Aβ1-14-εK-KKK-MvF5 Th acetate
    		Inhibitor 99.93%
    Aβ1-14-εK-KKK-MvF5 Th acetate is the acetate salt form of Aβ1-14-εK-KKK-MvF5 Th (HY-P5333). Aβ1-14-εK-KKK-MvF5 Th acetate is part of UB-311 vaccine, that targets the amyloid-beta (Aβ) protein, and ameliorates the Alzheimer’s disease.
    Aβ1-14-εK-KKK-MvF5 Th acetate
  • HY-P1880
    β-Amyloid (12-20)
    		99.91%
    β-Amyloid (12-20) is a peptide fragment of β-Amyloid.
    β-Amyloid (12-20)
  • HY-100275
    MK-3328
    		Inhibitor 99.70%
    MK-3328 is a β-Amyloid ligand, which exhibits high binding potency with an IC50 of 10.5 nM. MK-3328 is capable of being labelled with 18F for positron emission tomography (PET) imaging.
    MK-3328
  • HY-P10824
    RI-OR2-TAT
    		Inhibitor
    RI-OR2-TAT is a brain-penetrant inhibitor of β-Amyloid oligomerization, which is produced by adding the HIV protein transduction domain TAT to RI-OR2. RI-OR2-TAT binds to Aβ42 fibrils with a Kd value of 58-125 nM. RI-OR2-TAT reduces Aβ aggregation and plaque levels, reduces activation of microglia and oxidative damage, and increases the number of young neurons in the dentate gyrus.
    RI-OR2-TAT
  • HY-P1474A
    β-Amyloid (22-35) TFA
    β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 TFA forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution).
    β-Amyloid (22-35) TFA
  • HY-W440555
    4-Sulfocalix[4]arene
    		Ligand
    4-Sulfocalix[4]arene (para-Sulfonatocalix[n]arene) is a amyloid-beta 42 binder with a Kd of 5.39 M. 4-Sulfocalix[4]arene can inhibit amyloid β-peptide fibrillation and reduce amyloid cytotoxicity.
    4-Sulfocalix[4]arene
  • HY-156842
    MCAAD-3
    MCAAD-3 is a near-infrared Aβ imaging probe with blood-brain barrier penetrability. MCAAD-3 has a strong affinity for Aβ polymers (Ki >106 nM) and can label Aβ plaques in the brains of transgenic mice.
    MCAAD-3
  • HY-P1362A
    β-Amyloid (42-1), human TFA
    β-Amyloid (42-1), human TFA is the inactive form of Amyloid β Peptide (1-42). β-Amyloid (42-1), human TFA is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
    β-Amyloid (42-1), human TFA
  • HY-153417
    Anti-amyloid agent-1
    		Inhibitor 99.03%
    Anti-amyloid agent-1 (ex1140) is a potent anti-amyloid compound and inhibits amyloid aggregation, provides a useful method for amyloidosis research.
    Anti-amyloid agent-1
  • HY-P5096
    FITC-β-Ala-Amyloid β-Protein (1-42)
    FITC-β-Ala-Amyloid β-Protein (1-42) is a FITC tagged Aβ1-42 peptide. Aβ1-42 plays a key role in the pathogenesis of Alzheimer’s disease.
    FITC-β-Ala-Amyloid β-Protein (1-42)
  • HY-N6640
    2-O-Acetyl-20-hydroxyecdysone
    		99.61%
    2-O-Acetyl-20-hydroxyecdysone, an ecdysterones in insects and terrestrial plants, inhibits amyloid-β42 (Aβ42)-induced cytotoxicity. 2-O-Acetyl-20-hydroxyecdysone could decrease Aβ oligomer formation through promotion of fibrogenesis, transforming Aβ oligomers to the low-toxicity fibrils.
    2-O-Acetyl-20-hydroxyecdysone
  • HY-111513
    4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
    		Inhibitor 98.60%
    4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent which binds to Amyloid-β (1-40) with a KD of 1.7 nM.
    4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
  • HY-N5014
    Liensinine perchlorate
    		Inhibitor 99.67%
    Liensinine perchlorate is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine perchlorate suppresses autophagy and apoptosis, clears Aβ, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine perchlorate activates AMPK and inhibits the expression of HIF-1α and VEGF, thereby suppressing angiogenesis. Liensinine perchlorate exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine perchlorate can be used for the research of diseases such as Alzheimer's disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke.
    Liensinine perchlorate
  • HY-100723
    THK-523
    		98.27%
    THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease.
    THK-523
  • HY-P1388F
    FITC-Ahx-β-Amyloid (1-42), (rat/mouse) tris
    FITC-Ahx-β-Amyloid (1-42), (rat/mouse) (tris) is a fluorescently labeled (FITC) form of β-Amyloid (1-42), (rat/mouse) (HY-P1388), which can be used in Alzheimer's disease-related research, such as aggregation, fiber formation, cellular uptake or imaging experiments. This product is provided in the form of Tris salt.
    FITC-Ahx-β-Amyloid (1-42), (rat/mouse) tris
  • HY-P1850A
    β-Amyloid (1-20) acetate
    β-Amyloid (1-20) acetate is the acetate form of β-Amyloid (1-20)，which consists of amino acids 1 to 20 of beta amyloid protein.
    β-Amyloid (1-20) acetate
Cat. No. Product Name / Synonyms Application Reactivity