THK-523
Based on 1 Customer Validation
THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease.
For research use only. We do not sell to patients.
- Purity : 98.27%
- CAS No.: 1573029-17-0
- Formula: C17H15FN2O
- Molecular Weight:282.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Brain of tau transgenic mice[1]
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Dosage:0.35 μg/kg
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Administration:Intravenous injection;25-30 mins
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Result:Overexpressed Tau in brain.
Chemical Information
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CAS No. 1573029-17-0
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Appearance Solid
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Molecular Weight 282.31
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Formula C17H15FN2O
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Color Light yellow to yellow
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SMILES
NC1=CC=C(C2=NC3=CC=C(OCCF)C=C3C=C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (354.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Protocol for Hematoxylin-Eosin (H&E) Staining
Hematoxylin-eosin staining is a routine histological method that stains nuclei mainly blue-purple with hemalum and stains cytoplasm, extracellular matrix, and many stromal components pink with eosin, allowing tissue architecture, cell morphology, necrosis, inflammation, fibrosis, tumor growth pattern, and treatment-associated injury to be evaluated by light microscopy. In cancer cells, primary neurons, mouse tumor models, intestinal organoids, inflammatory macrophage preparations, and drug-screening tissues, H&E is a morphology assay rather than a molecular assay; it should be interpreted with complementary molecular or immunostaining assays when the biological question concerns specific proteins, RNA levels, ferroptosis, mitophagy, or immune phenotypes.
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ryuichi Harada, et al. Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology. Eur J Nucl Med Mol Imaging. 2013 Jan;40(1):125-32. [Content Brief]
[2]. Michelle T Fodero-Tavoletti, 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain. 2011 Apr;134(Pt 4):1089-100. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5422 mL | 17.7110 mL | 35.4221 mL | 88.5551 mL |
| 5 mM | 0.7084 mL | 3.5422 mL | 7.0844 mL | 17.7110 mL | |
| 10 mM | 0.3542 mL | 1.7711 mL | 3.5422 mL | 8.8555 mL | |
| 15 mM | 0.2361 mL | 1.1807 mL | 2.3615 mL | 5.9037 mL | |
| 20 mM | 0.1771 mL | 0.8856 mL | 1.7711 mL | 4.4278 mL | |
| 25 mM | 0.1417 mL | 0.7084 mL | 1.4169 mL | 3.5422 mL | |
| 30 mM | 0.1181 mL | 0.5904 mL | 1.1807 mL | 2.9518 mL | |
| 40 mM | 0.0886 mL | 0.4428 mL | 0.8856 mL | 2.2139 mL | |
| 50 mM | 0.0708 mL | 0.3542 mL | 0.7084 mL | 1.7711 mL | |
| 60 mM | 0.0590 mL | 0.2952 mL | 0.5904 mL | 1.4759 mL | |
| 80 mM | 0.0443 mL | 0.2214 mL | 0.4428 mL | 1.1069 mL | |
| 100 mM | 0.0354 mL | 0.1771 mL | 0.3542 mL | 0.8856 mL |
THK-523 Related Classifications
HY-100723 Related Classifications
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