2. Neuronal Signaling
  3. Amyloid-β
  4. THK-523

THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease.

For research use only. We do not sell to patients.

THK-523

THK-523 Chemical Structure

CAS No. : 1573029-17-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

THK-523 Related Antibodies

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Description

THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease[1].

In Vivo

THK-523 crosses the blood-brain barrier in mice and the in vivo retention rate in the brain of Tau transgenic mice increased[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Brain of tau transgenic mice[1]
Dosage: 0.35 μg/kg
Administration: Intravenous injection;25-30 mins
Result: Overexpressed Tau in brain.
Molecular Weight

282.31

Formula

C17H15FN2O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC1=CC=C(C2=NC3=CC=C(OCCF)C=C3C=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (354.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5422 mL 17.7110 mL 35.4221 mL
5 mM 0.7084 mL 3.5422 mL 7.0844 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5422 mL 17.7110 mL 35.4221 mL 88.5551 mL
5 mM 0.7084 mL 3.5422 mL 7.0844 mL 17.7110 mL
10 mM 0.3542 mL 1.7711 mL 3.5422 mL 8.8555 mL
15 mM 0.2361 mL 1.1807 mL 2.3615 mL 5.9037 mL
20 mM 0.1771 mL 0.8856 mL 1.7711 mL 4.4278 mL
25 mM 0.1417 mL 0.7084 mL 1.4169 mL 3.5422 mL
30 mM 0.1181 mL 0.5904 mL 1.1807 mL 2.9518 mL
40 mM 0.0886 mL 0.4428 mL 0.8856 mL 2.2139 mL
50 mM 0.0708 mL 0.3542 mL 0.7084 mL 1.7711 mL
60 mM 0.0590 mL 0.2952 mL 0.5904 mL 1.4759 mL
80 mM 0.0443 mL 0.2214 mL 0.4428 mL 1.1069 mL
100 mM 0.0354 mL 0.1771 mL 0.3542 mL 0.8856 mL
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THK-523 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

THK-5231573029-17-0THK523THK 523Amyloid-ββ-amyloid peptideAβAbetatau pathologytau imaging radiotracerAlzheimer diseaseInhibitorinhibitorinhibit

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