1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK Inhibitors

CDK Inhibitors

CDK1

CDK2

CDK3

CDK4

CDK5

CDK6

CDK7

CDK8

CDK9

CDK11

CDK12

CDK13

CDK14

CDK16

CDK19

CDC

CLK

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

CDK Inhibitors & Antagonists
Product Name CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Purity
Palbociclib      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                      99.96%
Palbociclib hydrochloride      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                      99.88%
Abemaciclib methanesulfonate
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk4/cyclin D1, IC50: 2 nM
Cdk5/p25, IC50: 355 nM
CDK5/p35, IC50: 287 nM
CDK6/cyclinD1, IC50: 10 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
 
CDK9/cyclinT1, IC50: 57 nM
                99.95%
Abemaciclib
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk4/cyclin D1, IC50: 2 nM
CDK5/p35, IC50: 287 nM
Cdk5/p25, IC50: 355 nM
CDK6/cyclinD1, IC50: 10 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
 
CDK9/cyclinT1, IC50: 57 nM
                99.69%
Ribociclib      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                      99.90%
YKL-5-124 TFA  
CDK2, IC50: 1300 nM
       
CDK7, IC50: 53.5 nM
CDK7/Mat1/CycH, IC50: 9.7 nM
 
CDK9, IC50: 3020 nM
               
K00546
Cdk1/cyclin B, IC50: 0.6 nM
cdk2/cyclin A, IC50: 0.5 nM
                           
CLK1, IC50: 8.9 nM
CLK3, IC50: 29.2 nM
98.78%
FIT-039                
CDK9/cyclinT1, IC50: 5.8 μM
                >98.0%
THZ531            
CDK7, IC50: 8.5 μM
 
CDK9, IC50: 10.5 μM
 
CDK12, IC50: 158 nM
CDK13, IC50: 69 nM
          99.86%
Dinaciclib
CDK1, IC50: 3 nM
CDK2, IC50: 1 nM
   
CDK5, IC50: 1 nM
     
CDK9, IC50: 4 nM
                99.73%
THZ1            
CDK7, IC50: 3.2 nM
                    98.82%
Ro-3306
CDK1, Ki: 20 nM
CDK1/cyclinB1, Ki: 35 nM
CDK1/cyclin A, Ki: 110 nM
CDK2/cyclinE, Ki: 340 nM
                              98.54%
Flavopiridol
CDK1/Cyc B1, IC50: 30 nM
CDK2/Cyc E, IC50: 170 nM
 
CDK4/Cyc D1, IC50: 100 nM
                          99.72%
AZD4573                
CDK9, IC50: 4 nM
                99.80%
Seliciclib
cdc2/cyclin B, IC50: 0.65 μM
cdk2/cyclin A, IC50: 0.7 μM
Cdk2/cyclin E2, IC50: 0.7 μM
   
CDK5/p35, IC50: 0.16 μM
                        99.94%
Palbociclib isethionate      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                      99.96%
NVP-2                
CDK9, IC50: 0.5 nM
                99.29%
PF-06873600  
CDK2, Ki: 0.09 nM
 
CDK4, Ki: 0.13 nM
 
CDK6, Ki: 0.16 nM
                      99.98%
CYC065  
CDK2
           
CDK9
                99.78%
Simurosertib                              
Cdc7, IC50: <0.3 nM
  99.07%
SB1317  
CDK2, IC50: 13 nM
                              99.96%
SR-4835                    
CDK12, IC50: 99 nM
CDK12, Kd: 98 nM
CDK13, Kd: 4.9 nM
          98.46%
SNS-032
CDK1, IC50: 480 nM
CDK2, IC50: 38 nM
 
CDK4, IC50: 925 nM
   
CDK7, IC50: 62 nM
 
CDK9, IC50: 4 nM
                98.50%
THZ1 Hydrochloride            
CDK7, IC50: 3.2 nM
                    98.70%
AT7519
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
                98.15%
Samuraciclib hydrochloride
CDK1/cyc A, IC50: 1.8 μM
cdk2/cyclin A, IC50: 578 nM
 
CDK4/Cyc D1, IC50: 49 μM
CDK5/p35NCK, IC50: 9.4 μM
CDK6/cycD1, IC50: 34 μM
CDK7/cyclin H, IC50: 41 nM
 
CDK9/CycT1, IC50: 1.2 μM
                99.98%
AZD-5438
cdk1-cyclin B1, IC50: 16 nM
cdk2-cyclin E, IC50: 6 nM
cdk2-cyclin A, IC50: 45 nM
 
cdk4-cyclin D1, IC50: 449 nM
cdk5-p25, IC50: 14 nM
cdk6-cyclin D3, IC50: 21 nM
cdk7-cyclin H, IC50: 821 nM
 
cdk9-cyclin T, IC50: 20 nM
                99.37%
Ribociclib succinate      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                      99.52%
GSK 3 Inhibitor IX
Cdk1/cyclin B, IC50: 320 nM
cdk2/cyclin A, IC50: 300 nM
 
Cdk4/cyclin D1, IC50: 10 μM
CDK5/p35, IC50: 80 nM
                        99.66%
JNJ-7706621
Cdk1/cyclin B, IC50: 9 nM
CDK2/cyclinE, IC50: 3 nM
cdk2/cyclin A, IC50: 4 nM
CDK3/Cyclin E, IC50: 58 nM
Cdk4/cyclin D1, IC50: 253 nM
 
CDK6/cyclinD1, IC50: 175 nM
                      99.91%
Wogonin              
CDK8
                  99.98%
CCT-251921              
CDK8, IC50: 2.3 nM
           
CDK19, IC50: 2.6 nM
    99.77%
OTS964 hydrochloride                  
CDK11B, Kd: 40 nM
              99.05%
AUZ 454  
CDK2(C118L/A144C), Kd: 9.7 nM
CDK2(A144C), Kd: 15.4 nM
CDK2(C118L), Kd: 18.6 nM
CDK2(WT), Kd: 50 nM
CDK2(C118L/A144C-Cyclin B), Kd: 134.1 nM
                              99.99%
Senexin A              
CDK8, Kd: 0.83 μM
           
CDK19, Kd: 0.31 μM
    99.94%
(+)-BAY-1251152                
CDK9/CycT1, IC50: 3 nM
                99.66%
Flavopiridol Hydrochloride
CDK1/Cyc B1, IC50: 30 nM
CDK2/Cyc E, IC50: 170 nM
 
CDK4/Cyc D1, IC50: 100 nM
                          99.74%
BI-1347              
CDK8, IC50: 1.1 nM
                  99.83%
Milciclib
cyclin B/CDK1, IC50: 398 nM
cyclin A/CDK2, IC50: 45 nM
cyclin E/CDK2, IC50: 363 nM
 
cyclin D1/CDK4, IC50: 160 nM
   
cyclin H/CDK7, IC50: 150 nM
                    99.92%
AS2863619              
CDK8, IC50: 0.61 nM
           
CDK19, IC50: 4.28 nM
    >98.0%
CVT-313
Cdk1/cyclin B, IC50: 4.2 μM
cdk2/cyclin A, IC50: 0.5 μM
 
Cdk4/cyclin D1, IC50: 215 μM
                          99.76%
TG003                                
CLK1, IC50: 20 nM
CLK2, IC50: 200 nM
Clk4, IC50: 15 nM
98.77%
LDC4297            
CDK7, IC50: 0.13 nM
                    99.14%
PHA-767491 hydrochloride
CDK1, IC50: 250 nM
CDK2, IC50: 240 nM
   
CDK5, IC50: 460 nM
     
CDK9, IC50: 34 nM
                99.91%
MSC2530818              
CDK8, IC50: 2.6 nM
                  99.69%
THZ2
CDK1, IC50: 96.9 nM
CDK2, IC50: 222 nM
   
CDK5, IC50: 134 nM
 
CDK7, IC50: 13.9 nM
CDK8, IC50: 6830 nM
CDK9, IC50: 194 nM
                99.03%
Trilaciclib hydrochloride      
Cdk4/cyclin D1, IC50: 1 nM
 
cdk6/cyclin D3, IC50: 4 nM
                      99.24%
LDC000067
cdk1-cyclin B1, IC50: 5513 nM
cdk2-cyclin A, IC50: 2441 nM
 
cdk4-cyclin D1, IC50: 9242 nM
       
CDK9- Cyclin T1, IC50: 44 nM
                98.58%
BMS-265246
CDK1/cycB, IC50: 6 nM
CDK2/Cyc E, IC50: 9 nM
 
CDK4/cycD, IC50: 230 nM
                          99.28%
XL413 hydrochloride                              
Cdc7, IC50: 3.4 nM
  99.72%
Atuveciclib
CDK1/CycB(h), IC50: 1100 nM
CDK2/CycE(h), IC50: 1000 nM
CDK3/CycE(h), IC50: 890 nM
 
CDK5/p35(h), IC50: 1600 nM
     
CDK9/CycT1, IC50: 13 nM
CDK9/CycT1(h), IC50: 6 nM
                99.20%
R547
Cdk1/cyclin B, Ki: 2 nM
Cdk1/cyclin B, IC50: 0.2 nM
CDK2/cyclinE, Ki: 3 nM
cdk2/cyclin A, IC50: 0.1 nM
CDK2/cyclinE, IC50: 0.4 nM
CDK3/Cyclin E, IC50: 0.8 nM
CDK4/cyclin D, Ki: 1 nM
CDK5/p35, IC50: 0.1 nM
cdk6/cyclin D3, IC50: 4 nM
CDK7/cyclin H, IC50: 171 nM
                    99.66%
BSJ-03-123          
CDK6
                      99.45%
MBQ-167                              
Cdc42, IC50: 78 nM
  99.26%
CLK1-IN-1                                
CLK1, IC50: 2 nM
99.03%
Purvalanol A
cdc2-cyclin B, IC50: 4 nM
cdk2-cyclin E, IC50: 35 nM
cdk2-cyclin A, IC50: 70 nM
 
cdk4-cyclin D1, IC50: 850 nM
cdk5-p35, IC50: 75 nM
                        99.11%
SY-1365            
CDK7
                    99.27%
SEL120-34A monohydrochloride              
CDK8/CycC, IC50: 4.4 nM
CDK9/cycT, IC50: 1070 nM
         
CDK19/CycC, IC50: 10.4 nM
    99.98%
LY2857785            
CDK7, IC50: 0.246 μM
CDK8, IC50: 0.016 μM
CDK9, IC50: 0.011 μM
                98.88%
PHA-793887
Cdk1/cyclin B, IC50: 60 nM
cdk2/cyclin A, IC50: 8 nM
CDK2/cyclinE, IC50: 8 nM
 
Cdk4/cyclin D1, IC50: 62 nM
Cdk5/p25, IC50: 5 nM
 
CDK7/cyclin H, IC50: 10 nM
 
CDK9/cyclinT1, IC50: 138 nM
                99.95%
ON123300      
Cdk4/cyclin D1, IC50: 3.87 nM
 
CDK6/cyclinD1, IC50: 9.82 nM
                      98.52%
Roniciclib
Cdk1/cyclin B, IC50: 7 nM
CDK2/cyclinE, IC50: 9 nM
 
CDK4/cyclin D, IC50: 11 nM
   
CDK7/Cyclin H/MAT1, IC50: 25 nM
 
CDK9/cyclinT1, IC50: 5 nM
                98.89%
CC-671                                
CLK2, IC50: 0.006 μM
98.86%
LY3177833                              
Cdc7, IC50: 3.3 nM
  99.78%
Ribociclib hydrochloride      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                      99.95%
KH-CB19                                
CLK1, IC50: 19.7 nM
CLK3, IC50: 530 nM
99.31%
Cucurbitacin E
cyclin B1/CDC2
                                99.92%
CDK2-IN-4
Cdk1/cyclin B, IC50: 86 μM
cdk2/cyclin A, IC50: 44 nM
                              >97.0%
CDKI-73
CDK1, IC50: 8.17 nM
CDK2, IC50: 3.27 nM
 
CDK4, IC50: 8.18 nM
 
CDK6, IC50: 37.68 nM
CDK7, IC50: 134.26 nM
 
CDK9, IC50: 5.78 nM
                99.58%
CDK9-IN-1                
CDK9/CycT1, IC50: 39 nM
                95.48%
PROTAC CDK9 Degrader-1                
CDK9
                99.04%
ML167                                
Clk4, IC50: 136 nM
CLK1, IC50: 1522 nM
CLK2, IC50: 1648 nM
98.62%
NU6300  
CDK2, IC50: 0.16 μM
                              97.03%
FN-1501  
cdk2/cyclin A, IC50: 2.47 nM
 
Cdk4/cyclin D1, IC50: 0.85 nM
 
CDK6/cyclinD1, IC50: 1.96 nM
                      98.41%
CDK12-IN-3                    
CDK12, IC50: 491 nM
            98.22%
FMF-04-159-2  
CDK2, IC50: 256 nM (in NanoBRET assay)
                   
CDK14/Cyclin Y, IC50: 39.6 nM (in NanoBRET assay)
        99.34%
SU9516
CDK1, IC50: 40 nM
CDK2, IC50: 22 nM
 
CDK4, IC50: 200 nM
                          99.83%
CLK-IN-T3                                
CLK1, IC50: 0.67 nM
CLK2, IC50: 15 nM
CLK3, IC50: 110 nM
98.19%
SEL120-34A HCl              
CDK8/CycC, IC50: 4.4 nM
CDK9/cycT, IC50: 1070 nM
         
CDK19/CycC, IC50: 10.4 nM
    99.80%
CDK-IN-2                
CDK9/cyclinT1, IC50: 8 nM
                98.82%
AT7519 Hydrochloride
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
                99.99%
MC180295
CDK1-Cyclin B, IC50: 138 nM
cdk2-cyclin A, IC50: 233 nM
cdk2-cyclin E, IC50: 367 nM
CDK3-Cyclin E, IC50: 399 nM
CDK4-Cyclin D, IC50: 112 nM
cdk5-p35, IC50: 159 nM
cdk5-p25, IC50: 186 nM
cdk6-cyclin D3, IC50: 712 nM
CDK7-CycH/MAT1, IC50: 555 nM
 
CDK9- Cyclin T1, IC50: 5 nM
                98.47%
Lerociclib dihydrochloride
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 832 nM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
 
CDK9/Cyclin T, IC50: 28 nM
                98.45%
(R)​-​CR8 trihydrochloride
CDK1/cyclinB1, IC50: 0.09 μM
cdk2/cyclin A, IC50: 0.072 μM
CDK2/cyclinE, IC50: 0.041 μM
   
Cdk5/p25, IC50: 0.11 μM
 
CDK7/cyclin H, IC50: 1.1 μM
 
CDK9/Cyclin T, IC50: 0.18 μM
                99.02%
Purvalanol B
cdc2/cyclin B, IC50: 6 nM
cyclin dependent kinase 1-cyclinB, IC50: 6 nM
cdk2/cyclin A, IC50: 6 nM
CDK2/cyclinE, IC50: 9 nM
 
Cdk4/cyclin D1, IC50: 10000 nM
CDK5/p35, IC50: 6 nM
                        >97.0%
Atuveciclib Racemate                
CDK9
                98.48%
Longdaysin            
CDK7, IC50: 29 μM
                    99.92%
ON-013100      
Cdk4/cyclin D1
                          98.23%
Voruciclib hydrochloride
CDK1/cycB, Ki: 5.4 nM
CDK1/cyc A, Ki: 9.1 nM
   
CDK4/Cyc D1, Ki: 3.96 nM
 
CDK6/cycD1, Ki: 2.92 nM
   
CDK9/CycT1, Ki: 1.68 nM
CDK9/cyc T2, Ki: 0.626 nM
                98.20%
Riviciclib hydrochloride
CDK1-Cyclin B, IC50: 0.079 μM
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.500 μM
 
cdk4-cyclin D1, IC50: 0.063 μM
 
cdk6-cyclin D3, IC50: 0.396 μM
   
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
                98.33%
CP-10          
CDK6, DC50: 2.1 nM
                      98.03%
EHT 5372                                
CLK1, IC50: 22.8 nM
CLK2, IC50: 88.8 nM
Clk4, IC50: 59 nM
98.07%
Bisindolylmaleimide X hydrochloride  
CDK2, IC50: 200 nM
                              98.53%
JSH-150
Cdk1/cyclin B, IC50: 1.34 μM
cdk2/cyclin A, IC50: 2.86 μM
   
Cdk5/p25, IC50: 4.64 μM
 
CDK7/Cyclin H/MNAT1, IC50: 1.72 μM
 
CDK9/cyclinT1, IC50: 1 nM
     
CDK14/Cyclin Y, IC50: 1.68 μM
CDK16/Cyclin Y, IC50: 292 nM
      98.36%
(R)​-​CR8
Cdk1/cyclin B, IC50: 0.09 μM
cdk2/cyclin A, IC50: 0.072 μM
CDK2/cyclinE, IC50: 0.041 μM
   
Cdk5/p25, IC50: 0.11 μM
 
CDK7/cyclin H, IC50: 1.1 μM
 
CDK9/Cyclin T, IC50: 0.18 μM
                >98.0%
CDK4/6-IN-4      
CDK4
 
CDK6
                      98.24%
Ribociclib succinate hydrate      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                      99.96%
NG 52
cdc2-cyclin B, IC50: 0.34 μM
     
Pho85p, IC50: 2 nM
                        99.93%
JH-XI-10-02              
CDK8, IC50: 159 nM
                 
(-)-BAY-1251152                
CDK9
                99.82%
BGG463  
CDK2
                              >98.0%
CDK9-IN-7      
CDK4/cyclin D, IC50: 148 nM
 
CDK6/cyclinD, IC50: 145 nM
   
CDK9/cyclinT1, IC50: 11 nM
                99.81%
AMG 925
CDK1, IC50: 1.9 μM
CDK2, IC50: 375 nM
 
CDK4, IC50: 3 nM
 
CDK6, IC50: 8 nM
                      99.33%
CDK9-IN-8                
CDK9, IC50: 12 nM
                99.06%
AS2863619 free base              
CDK8, IC50: 0.61 nM
           
CDK19, IC50: 4.28 nM
    >98.0%
CKI-7 free base                              
Cdc7
  99.31%
Alsterpaullone
Cdk1/cyclin B, IC50: 35 nM
cdk2/cyclin A, IC50: 15 nM
CDK2/Cyc E, IC50: 200 nM
   
CDK5/p35, IC50: 40 nM
                        97.30%
Abemaciclib Metabolites M2      
CDK4, IC50: 1-3 nM
 
CDK6, IC50: 1-3 nM
                      99.39%
LSN3106729 hydrochloride      
CDK4
 
CDK6
                      99.01%
NU2058
CDK1, IC50: 26 μM
CDK2, IC50: 17 μM
CDK2, Ki: 12 μM
                              99.01%
BS-181 hydrochloride
CDK1/cycB, IC50: 8.1 μM
CDK2/Cyc E, IC50: 0.88 μM
 
CDK4/Cyc D1, IC50: 33 μM
CDK5/p35NCK, IC50: 3 μM
CDK6/cycD1, IC50: 47 μM
CDK7/CycH/MAT1, IC50: 0.021 μM
 
CDK9/cycT, IC50: 4.2 μM
                >99.0%
CDK8-IN-1              
CDK8, IC50: 3 nM
                  98.62%
NU6140
CDK1-Cyclin B, IC50: 6.6 μM
cdk2-cyclin A, IC50: 0.41 μM
 
CDK4-Cyclin D, IC50: 5.5 μM
cdk5-p25, IC50: 15 μM
 
cdk7-cyclin H, IC50: 3.9 μM
                    >99.0%
CDK12-IN-E9  
cdk2/cyclin A, IC50: 932 nM
       
CDK7/Cyclin H/MNAT1, IC50: 1210 nM
 
CDK9/cyclinT1, IC50: 23.9 nM
                99.20%
Voruciclib
CDK1/cycB, Ki: 5.4 nM
CDK1/cyc A, Ki: 9.1 nM
   
CDK4/Cyc D1, Ki: 3.96 nM
 
CDK6/cycD1, Ki: 2.92 nM
   
CDK9/cyc T2, Ki: 0.626 nM
CDK9/CycT1, Ki: 1.68 nM
                99.52%
Olomoucine  
cdk2-cyclin A, IC50: 7 μM
cdk2-cyclin E, IC50: 7 μM
                              >98.0%
AMG 925 HCl
CDK1, IC50: 1.9 μM
CDK2, IC50: 375 nM
 
CDK4, IC50: 3 nM
 
CDK6, IC50: 8 nM
                      98.01%
5-Iodo-indirubin-3'-monoxime
Cdk1/cyclin B, IC50: 25 nM
     
Cdk5/p25, IC50: 20 nM
                        99.50%
PNU112455A hydrochloride  
CDK2, Km: 3.6 μM
   
CDK5, Km: 3.2 μM
                        99.62%
Desmethylglycitein
CDK1
CDK2
                              >95.0%
Garcinone C            
CDK7
                   
AT7519 trifluoroacetate
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
                98.16%
NVP-LCQ195
Cdk1/cyclin B, IC50: 2 nM
cdk2/cyclin A, IC50: 2 nM
CDK2/cyclinE, IC50: 5 nM
CDK3/Cyclin E, IC50: 42 nM
 
Cdk5/p25, IC50: 1 nM
CDK5/p35, IC50: 1 nM
cdk6/cyclin D3, IC50: 187 nM
CDK7/Cyclin H/MAT1, IC50: 3564 nM
 
CDK9/cyclinT1, IC50: 15 nM
                99.80%
CDK8/19-IN-1              
CDK8/CycC, IC50: 0.46 nM
CDK9, IC50: 270 nM
         
CDK19/CycC, IC50: 0.99 nM
   
PROTAC CDK9 degrader-2                
CDK9, IC50: 17 μM (MCF-7 cells)
               
CDK7-IN-1            
CDK7, IC50: 100 nM
                    99.82%
BSJ-04-132      
CDK4/D1, IC50: 50.6 nM
 
CDK6/D1, IC50: 30 nM
                     
CAN508
Cdk1/cyclin B, IC50: 44 μM
CDK2/cyclinE, IC50: 20 μM
cdk2/cyclin A, IC50: 69 μM
 
Cdk4/cyclin D1, IC50: 13.5 μM
   
CDK7/cyclin H, IC50: 26 μM
 
CDK9/cyclinT1, IC50: 0.35 μM
               
BSJ-03-204      
CDK4/D1, IC50: 26.9 nM
 
CDK6/D1, IC50: 10.4 nM
                     
CDK4/6-IN-2      
CDK4, IC50: 2.7 nM
 
CDK6, IC50: 16 nM
                      99.82%
CDK7-IN-2 hydrochloride hydrate            
CDK7
                   
CKI-7                              
Cdc7
 
Palbociclib D8      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                     
NU6027
CDK1, Ki: 2.5 μM
CDK2, Ki: 1.3 μM
                             
CDK9-IN-11                
CDK9
               
Bohemine  
CDK2/cyclinE, IC50: 4.6 μM
cdk2/cyclin A, IC50: 83 μM
           
CDK9/cyclinT1, IC50: 2.7 μM
               
YKL-5-124  
CDK2, IC50: 1300 nM
       
CDK7, IC50: 53.5 nM
CDK7/Mat1/CycH, IC50: 9.7 nM
 
CDK9, IC50: 3020 nM
               
Nimbolide      
CDK4
 
CDK6
                     
Indirubin-3'-monoxime-5-sulphonic acid
CDK1, IC50: 5 nM
     
CDK5, IC50: 7 nM
                       
Indirubin-5-sulfonate
Cdk1/cyclin B, IC50: 55 nM
cdk2/cyclin A, IC50: 35 nM
CDK2/cyclinE, IC50: 150 nM
 
Cdk4/cyclin D1, IC50: 300 nM
CDK5/p35, IC50: 65 nM
                       
CDK9-IN-10                
CDK9
               
CDK5 inhibitor 20-223  
CDK2, IC50: 6.0 nM
   
CDK5, IC50: 8.8 nM