1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK Inhibitors

CDK Inhibitors

CDK1

CDK2

CDK3

CDK4

CDK5

CDK6

CDK7

CDK8

CDK9

CDK11

CDK12

CDK13

CDK14

CDK16

CDK19

CDC

CLK

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

CDK Inhibitors
Product Name CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Purity
Palbociclib      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                      99.96%
Abemaciclib methanesulfonate
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk4/cyclin D1, IC50: 2 nM
Cdk5/p25, IC50: 355 nM
CDK5/p35, IC50: 287 nM
CDK6/cyclinD1, IC50: 10 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
 
CDK9/cyclinT1, IC50: 57 nM
                99.95%
Palbociclib hydrochloride      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                      99.94%
Ribociclib      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                      99.85%
THZ531                    
CDK12, IC50: 158 nM
CDK13, IC50: 69 nM
          99.86%
BI-1347              
CDK8, IC50: 1.1 nM
                  99.83%
Dinaciclib
CDK1, IC50: 3 nM
CDK2, IC50: 1 nM
   
CDK5, IC50: 1 nM
     
CDK9, IC50: 4 nM
                99.73%
Seliciclib
cdc2/cyclin B, IC50: 0.65 μM
cdk2/cyclin A, IC50: 0.7 μM
Cdk2/cyclin E2, IC50: 0.7 μM
   
CDK5/p35, IC50: 0.16 μM
                        99.94%
THZ1            
CDK7, IC50: 3.2 nM
                    98.82%
NVP-2                
CDK9, IC50: 0.5 nM
                99.29%
Palbociclib isethionate      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                      99.96%
CYC065  
CDK2
           
CDK9
                99.78%
Abemaciclib
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk4/cyclin D1, IC50: 2 nM
CDK5/p35, IC50: 287 nM
Cdk5/p25, IC50: 355 nM
CDK6/cyclinD1, IC50: 10 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
 
CDK9/cyclinT1, IC50: 57 nM
                99.69%
THZ1 Hydrochloride            
CDK7, IC50: 3.2 nM
                    98.70%
AZD4573                
CDK9, IC50: 3 nM
                99.80%
Atuveciclib Racemate                
CDK9
                98.48%
PF-06873600  
CDK2, Ki: 0.09 nM
 
CDK4, Ki: 0.13 nM
 
CDK6, Ki: 0.16 nM
                      99.98%
SNS-032
CDK1, IC50: 480 nM
CDK2, IC50: 38 nM
 
CDK4, IC50: 925 nM
   
CDK7, IC50: 62 nM
 
CDK9, IC50: 4 nM
                98.50%
Ribociclib succinate      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                      99.93%
CT7001 hydrochloride  
CDK2/cycE1, IC50: 578 nM
       
CDK7/CycH/MAT1, IC50: 41 nM
                    99.98%
AZD-5438
cdk1-cyclin B1, IC50: 16 nM
cdk2-cyclin E, IC50: 6 nM
cdk2-cyclin A, IC50: 45 nM
 
cdk4-cyclin D1, IC50: 449 nM
cdk5-p25, IC50: 14 nM
cdk6-cyclin D3, IC50: 21 nM
cdk7-cyclin H, IC50: 821 nM
 
cdk9-cyclin T, IC50: 20 nM
                99.37%
AT7519
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
                98.15%
Wogonin              
CDK8
                  99.98%
GSK 3 Inhibitor IX
Cdk1/cyclin B, IC50: 320 nM
cdk2/cyclin A, IC50: 300 nM
 
Cdk4/cyclin D1, IC50: 10 μM
CDK5/p35, IC50: 80 nM
                        99.66%
CCT-251921              
CDK8, IC50: 2.3 nM
           
CDK19, IC50: 2.6 nM
    98.70%
Milciclib
cyclin B/CDK1, IC50: 398 nM
cyclin A/CDK2, IC50: 45 nM
cyclin E/CDK2, IC50: 363 nM
 
cyclin D1/CDK4, IC50: 160 nM
   
cyclin H/CDK7, IC50: 150 nM
                    98.61%
JNJ-7706621
Cdk1/cyclin B, IC50: 9 nM
CDK2/cyclinE, IC50: 3 nM
cdk2/cyclin A, IC50: 4 nM
CDK3/Cyclin E, IC50: 58 nM
Cdk4/cyclin D1, IC50: 253 nM
 
CDK6/cyclinD1, IC50: 175 nM
                      99.91%
AUZ 454  
CDK2(C118L/A144C), Kd: 9.7 nM
CDK2(A144C), Kd: 15.4 nM
CDK2(C118L), Kd: 18.6 nM
CDK2(WT), Kd: 50 nM
CDK2(C118L/A144C-Cyclin B), Kd: 134.1 nM
                              99.99%
(+)-BAY-1251152                
CDK9, IC50: 3 nM
                99.66%
CVT-313
Cdk1/cyclin B, IC50: 4.2 μM
cdk2/cyclin A, IC50: 0.5 μM
 
Cdk4/cyclin D1, IC50: 215 μM
                          99.76%
Senexin A              
CDK8, Kd: 0.83 μM
           
CDK19, Kd: 0.31 μM
    99.93%
PHA-767491 hydrochloride
CDK1, IC50: 250 nM
CDK2, IC50: 240 nM
   
CDK5, IC50: 460 nM
     
CDK9, IC50: 34 nM
                99.91%
MSC2530818              
CDK8, IC50: 2.6 nM
                  99.59%
Purvalanol A
cdc2-cyclin B, IC50: 4 nM
cdk2-cyclin E, IC50: 35 nM
cdk2-cyclin A, IC50: 70 nM
 
cdk4-cyclin D1, IC50: 850 nM
cdk5-p35, IC50: 75 nM
                        98.66%
LDC000067
cdk1-cyclin B1, IC50: 5513 nM
cdk2-cyclin A, IC50: 2441 nM
 
cdk4-cyclin D1, IC50: 9242 nM
       
CDK9- Cyclin T1, IC50: 44 nM
                98.14%
OTS-964                  
CDK11B, Kd: 40 nM
              99.05%
Trilaciclib hydrochloride      
Cdk4/cyclin D1, IC50: 1 nM
 
cdk6/cyclin D3, IC50: 4 nM
                      99.24%
Flavopiridol Hydrochloride
CDK1/Cyc B1, IC50: 30 nM
CDK2/Cyc E, IC50: 170 nM
 
CDK4/Cyc D1, IC50: 100 nM
                          99.00%
CDKI-73
CDK1, IC50: 8.17 nM
CDK2, IC50: 3.27 nM
 
CDK4, IC50: 8.18 nM
 
CDK6, IC50: 37.68 nM
CDK7, IC50: 134.26 nM
 
CDK9, IC50: 5.78 nM
                99.58%
Simurosertib                              
Cdc7, IC50: 0.3 nM
  99.07%
AT7519 Hydrochloride
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
                99.99%
SU9516
CDK1, IC50: 40 nM
CDK2, IC50: 22 nM
 
CDK4, IC50: 200 nM
                          99.76%
Cucurbitacin E
cyclin B1/CDC2
                                99.92%
R547
Cdk1/cyclin B, Ki: 2 nM
CDK2/cyclinE, Ki: 3 nM
 
CDK4/cyclin D, Ki: 1 nM
                          98.42%
BMS-265246
CDK1/cycB, IC50: 6 nM
CDK2/Cyc E, IC50: 9 nM
 
CDK4/cycD, IC50: 230 nM
                          97.47%
Atuveciclib
CDK1/CycB(h), IC50: 1100 nM
CDK2/CycE(h), IC50: 1000 nM
CDK3/CycE(h), IC50: 890 nM
 
CDK5/p35(h), IC50: 1600 nM
     
CDK9/CycT1, IC50: 13 nM
CDK9/CycT1(h), IC50: 6 nM
                99.42%
CC-671                                
Clk2, IC50: 0.006 μM
98.86%
LY3177833                              
Cdc7, IC50: 3.3 nM
  99.78%
Ribociclib hydrochloride      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                      99.83%
LY2857785            
CDK7, IC50: 0.246 μM
CDK8, IC50: 0.016 μM
CDK9, IC50: 0.011 μM
                98.59%
XL413 hydrochloride                              
Cdc7, IC50: 3.4 nM
  99.72%
KH-CB19                                
CLK1, IC50: 19.7 nM
CLK3, IC50: 530 nM
99.31%
CDK9-IN-1                
CDK9/CycT1, IC50: 39 nM
                95.48%
NU6300  
CDK2, IC50: 0.16 μM
                              97.03%
PROTAC CDK9 Degrader-1                
CDK9
                99.04%
ML167                                
Clk4, IC50: 136 nM
CLK1, IC50: 1522 nM
Clk2, IC50: 1648 nM
98.51%
SEL120-34A HCl              
CDK8/CycC, IC50: 4.4 nM
CDK9/cycT, IC50: 1070 nM
         
CDK19/CycC, IC50: 10.4 nM
    99.80%
SEL120-34A monohydrochloride              
CDK8/CycC, IC50: 4.4 nM
CDK9/cycT, IC50: 1070 nM
         
CDK19/CycC, IC50: 10.4 nM
    99.98%
Purvalanol B
cdc2/cyclin B, IC50: 6 nM
cyclin dependent kinase 1-cyclinB, IC50: 6 nM
cdk2/cyclin A, IC50: 6 nM
CDK2/cyclinE, IC50: 9 nM
 
Cdk4/cyclin D1, IC50: 10000 nM
CDK5/p35, IC50: 6 nM
                        >97.0%
Lerociclib dihydrochloride
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 832 nM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
 
CDK9/Cyclin T, IC50: 28 nM
                98.45%
MC180295
CDK1-Cyclin B, IC50: 138 nM
cdk2-cyclin A, IC50: 233 nM
cdk2-cyclin E, IC50: 367 nM
CDK3-Cyclin E, IC50: 399 nM
CDK4-Cyclin D, IC50: 112 nM
cdk5-p35, IC50: 159 nM
cdk5-p25, IC50: 186 nM
cdk6-cyclin D3, IC50: 712 nM
CDK7-CycH/MAT1, IC50: 555 nM
 
CDK9- Cyclin T1, IC50: 5 nM
                98.47%
MBQ-167                              
Cdc42, IC50: 78 nM
  99.26%
ON123300      
Cdk4/cyclin D1, IC50: 3.87 nM
 
CDK6/cyclinD1, IC50: 9.82 nM
                     
CLK1-IN-1                                
CLK1, IC50: 2 nM
99.03%
CDK-IN-2                
CDK9/cyclinT1, IC50: 8 nM
                97.54%
AMG 925
CDK1, IC50: 1.9 μM
CDK2, IC50: 375 nM
 
CDK4, IC50: 3 nM
 
CDK6, IC50: 8 nM
                      99.33%
BGG463  
CDK2
                              >98.0%
Ribociclib succinate hydrate      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                      99.00%
NG 52
cdc2-cyclin B, IC50: 0.34 μM
     
Pho85p, IC50: 2 nM
                        99.93%
NVP-LCQ195
Cdk1/cyclin B, IC50: 2 nM
cdk2/cyclin A, IC50: 2 nM
CDK2/cyclinE, IC50: 5 nM
CDK3/Cyclin E, IC50: 42 nM
 
Cdk5/p25, IC50: 1 nM
CDK5/p35, IC50: 1 nM
cdk6/cyclin D3, IC50: 187 nM
CDK7/Cyclin H/MAT1, IC50: 3564 nM
 
CDK9/cyclinT1, IC50: 15 nM
                98.99%
FN-1501  
cdk2/cyclin A, IC50: 2.47 nM
 
Cdk4/cyclin D1, IC50: 0.85 nM
 
CDK6/cyclinD1, IC50: 1.96 nM
                      98.41%
JSH-150
Cdk1/cyclin B, IC50: 1.34 μM
cdk2/cyclin A, IC50: 2.86 μM
   
Cdk5/p25, IC50: 4.64 μM
 
CDK7/Cyclin H/MNAT1, IC50: 1.72 μM
 
CDK9/cyclinT1, IC50: 1 nM
     
CDK14/Cyclin Y, IC50: 1.68 μM
CDK16/Cyclin Y, IC50: 292 nM
      92.04%
ON-013100      
Cdk4/cyclin D1
                          98.23%
CDK2-IN-4
Cdk1/cyclin B, IC50: 86 μM
cdk2/cyclin A, IC50: 44 nM
                              95.70%
Voruciclib hydrochloride
CDK1/cycB, Ki: 5.4 nM
CDK1/cyc A, Ki: 9.1 nM
   
CDK4/Cyc D1, Ki: 3.96 nM
 
CDK6/cycD1, Ki: 2.92 nM
   
CDK9/CycT1, Ki: 1.68 nM
CDK9/cyc T2, Ki: 0.626 nM
               
Alsterpaullone
Cdk1/cyclin B, IC50: 35 nM
cdk2/cyclin A, IC50: 15 nM
CDK2/Cyc E, IC50: 200 nM
   
CDK5/p35, IC50: 40 nM
                        97.30%
NU2058
CDK1, IC50: 26 μM
CDK2, IC50: 17 μM
                              99.01%
Longdaysin            
CDK7, IC50: 29 μM
                    99.92%
XL413                              
Cdc7, IC50: 3.4 nM
 
AT7519 trifluoroacetate
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
                98.16%
AMG 925 HCl
CDK1, IC50: 1.9 μM
CDK2, IC50: 375 nM
 
CDK4, IC50: 3 nM
 
CDK6, IC50: 8 nM
                      98.01%
SEL120-34A              
CDK8/CycC, IC50: 4.4 nM
CDK9/cycT, IC50: 1070 nM
         
CDK19/CycC, IC50: 10.4 nM
   
Roniciclib
Cdk1/cyclin B, IC50: 7 nM
CDK2/cyclinE, IC50: 9 nM
 
CDK4/cyclin D, IC50: 11 nM
   
CDK7/Cyclin H/MAT1, IC50: 25 nM
 
CDK9/cyclinT1, IC50: 5 nM
               
BS-181 hydrochloride
CDK1/cycB, IC50: 8.1 μM
CDK2/Cyc E, IC50: 0.88 μM
 
CDK4/Cyc D1, IC50: 33 μM
CDK5/p35NCK, IC50: 3 μM
CDK6/cycD1, IC50: 47 μM
CDK7/CycH/MAT1, IC50: 0.021 μM
 
CDK9/cycT, IC50: 4.2 μM
               
JH-XI-10-02              
CDK8, IC50: 159 nM
                 
CDK8-IN-1              
CDK8, IC50: 3 nM
                 
SY-1365            
CDK7
                   
CDK4/6-IN-3
CDK1, Ki: 110 nM
   
CDK4, Ki: 0.3 nM
 
CDK6, Ki: 2.2 nM
                     
FMF-04-159-2  
CDK2, IC50: 256 nM (in NanoBRET assay)
                   
CDK14/Cyclin Y, IC50: 39.6 nM (in NanoBRET assay)
       
CDK8/19-IN-1              
CDK8/CycC, IC50: 0.46 nM
CDK9, IC50: 270 nM
         
CDK19/CycC, IC50: 0.99 nM
   
Riviciclib hydrochloride
CDK1-Cyclin B, IC50: 0.079 μM
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.500 μM
 
cdk4-cyclin D1, IC50: 0.063 μM
 
cdk6-cyclin D3, IC50: 0.396 μM
   
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
               
CDK9 Antagonist-1                
CDK9, IC50: 17 μM (MCF-7 cells)
               
CDK9-IN-7      
CDK4/cyclin D, IC50: 148 nM
 
CDK6/cyclinD, IC50: 145 nM
   
CDK9/cyclinT1, IC50: 11 nM
               
IIIM-290  
CDK2/A, IC50: 90 nM
           
CDK9/T1, IC50: 94 nM
               
Riviciclib
CDK1-Cyclin B, IC50: 0.079 μM
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.540 μM
 
cdk4-cyclin D1, IC50: 0.063 μM
 
cdk6-cyclin D3, IC50: 0.396 μM
   
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
               
(-)-BAY-1251152                
CDK9
                99.82%
CDK9-IN-8                
CDK9, IC50: 12 nM
               
CP-10          
CDK6, DC50: 2.1 nM
                     
NU6140
CDK1-Cyclin B, IC50: 6.6 μM
cdk2-cyclin A, IC50: 0.41 μM
 
CDK4-Cyclin D, IC50: 5.5 μM
cdk5-p25, IC50: 15 μM
 
cdk7-cyclin H, IC50: 3.9 μM
                    >99.0%
GSK3186899
CRK12
                               
Lerociclib
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 0.832 μM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
 
CDK9/Cyclin T, IC50: 28 nM
               
CDK4/6-IN-2      
CDK4, IC50: 2.7 nM
 
CDK6, IC50: 16 nM
                      99.82%
Abemaciclib Metabolites M2      
CDK4, IC50: 1-3 nM
 
CDK6, IC50: 1-3 nM
                     
5-Iodo-indirubin-3'-monoxime
Cdk1/cyclin B, IC50: 25 nM
     
Cdk5/p25, IC50: 20 nM
                       
Desmethylglycitein
CDK1
CDK2
                             
Nimbolide      
CDK4
 
CDK6
                     
CDK12-IN-3                    
CDK12, IC50: 491 nM
           
Indirubin-3'-monoxime-5-sulphonic acid
CDK1, IC50: 5 nM
     
CDK5, IC50: 7 nM
                       
Garcinone C            
CDK7
                   
Indirubin-5-sulfonate
Cdk1/cyclin B, IC50: 55 nM
cdk2/cyclin A, IC50: 35 nM
CDK2/cyclinE, IC50: 150 nM
 
Cdk4/cyclin D1, IC50: 300 nM
CDK5/p35, IC50: 65 nM
                       
PHA-767491
CDK1, IC50: 250 nM
CDK2, IC50: 240 nM
   
CDK5, IC50: 460 nM
     
CDK9, IC50: 34 nM