CDK Inhibitors

CDK1

CDK2

CDK3

CDK4

CDK5

CDK6

CDK7

CDK8

CDK9

CDK11

CDK12

CDK13

CDK14

CDK16

CDK19

CDC

CLK

CDK Inhibitors & Antagonists

Product Name	CDK1	CDK2	CDK3	CDK4	CDK5	CDK6	CDK7	CDK8	CDK9	CDK11	CDK12	CDK13	CDK14	CDK16	CDK19	CDC	CLK	Purity
Palbociclib				Cdk4/cyclin D3, IC₅₀: 9 nM Cdk4/cyclin D1, IC₅₀: 11 nM		Cdk6/cyclin D2, IC₅₀: 16 nM												99.96%
Abemaciclib methanesulfonate	CDK1/cyclinB1, IC₅₀: 1627 nM	CDK2/cyclinE, IC₅₀: 504 nM		Cdk4/cyclin D1, IC₅₀: 2 nM	Cdk5/p25, IC₅₀: 355 nM CDK5/p35, IC₅₀: 287 nM	CDK6/cyclinD1, IC₅₀: 10 nM	CDK7/Mat1/cyclinH1, IC₅₀: 3910 nM		CDK9/cyclinT1, IC₅₀: 57 nM									99.95%
Palbociclib hydrochloride				Cdk4/cyclin D3, IC₅₀: 9 nM Cdk4/cyclin D1, IC₅₀: 11 nM		Cdk6/cyclin D2, IC₅₀: 16 nM												99.94%
Dinaciclib	CDK1, IC₅₀: 3 nM	CDK2, IC₅₀: 1 nM			CDK5, IC₅₀: 1 nM				CDK9, IC₅₀: 4 nM									99.73%
Ribociclib				CDK4, IC₅₀: 10 nM		CDK6, IC₅₀: 39 nM												99.85%
BI-1347								CDK8, IC₅₀: 1.1 nM										99.83%
CDK2-IN-4	Cdk1/cyclin B, IC₅₀: 86 μM	cdk2/cyclin A, IC₅₀: 44 nM																>97.0%
THZ531											CDK12, IC₅₀: 158 nM	CDK13, IC₅₀: 69 nM						99.86%
Seliciclib	cdc2/cyclin B, IC₅₀: 0.65 μM	cdk2/cyclin A, IC₅₀: 0.7 μM Cdk2/cyclin E2, IC₅₀: 0.7 μM			CDK5/p35, IC₅₀: 0.16 μM													99.94%
THZ1							CDK7, IC₅₀: 3.2 nM											98.82%
Flavopiridol	CDK1/Cyc B1, IC₅₀: 30 nM	CDK2/Cyc E, IC₅₀: 170 nM		CDK4/Cyc D1, IC₅₀: 100 nM														99.72%
Ro-3306	CDK1, Ki: 20 nM CDK1/cyclinB1, Ki: 35 nM CDK1/cyclin A, Ki: 110 nM	CDK2/cyclinE, Ki: 340 nM																96.77%
NVP-2									CDK9, IC₅₀: 0.5 nM									99.29%
Palbociclib isethionate				Cdk4/cyclin D3, IC₅₀: 9 nM Cdk4/cyclin D1, IC₅₀: 11 nM		Cdk6/cyclin D2, IC₅₀: 16 nM												99.96%
Abemaciclib	CDK1/cyclinB1, IC₅₀: 1627 nM	CDK2/cyclinE, IC₅₀: 504 nM		Cdk4/cyclin D1, IC₅₀: 2 nM	CDK5/p35, IC₅₀: 287 nM Cdk5/p25, IC₅₀: 355 nM	CDK6/cyclinD1, IC₅₀: 10 nM	CDK7/Mat1/cyclinH1, IC₅₀: 3910 nM		CDK9/cyclinT1, IC₅₀: 57 nM									99.69%
CYC065		CDK2							CDK9									99.78%
AZD4573									CDK9, IC₅₀: 4 nM									99.80%
PF-06873600		CDK2, Ki: 0.09 nM		CDK4, Ki: 0.13 nM		CDK6, Ki: 0.16 nM												99.98%
THZ1 Hydrochloride							CDK7, IC₅₀: 3.2 nM											98.70%
SNS-032	CDK1, IC₅₀: 480 nM	CDK2, IC₅₀: 38 nM		CDK4, IC₅₀: 925 nM			CDK7, IC₅₀: 62 nM		CDK9, IC₅₀: 4 nM									98.50%
Ribociclib succinate				CDK4, IC₅₀: 10 nM		CDK6, IC₅₀: 39 nM												99.84%
CT7001 hydrochloride		CDK2/cycE1, IC₅₀: 578 nM					CDK7/CycH/MAT1, IC₅₀: 41 nM											99.98%
Atuveciclib Racemate									CDK9									98.48%
AZD-5438	cdk1-cyclin B1, IC₅₀: 16 nM	cdk2-cyclin E, IC₅₀: 6 nM cdk2-cyclin A, IC₅₀: 45 nM		cdk4-cyclin D1, IC₅₀: 449 nM	cdk5-p25, IC₅₀: 14 nM	cdk6-cyclin D3, IC₅₀: 21 nM	cdk7-cyclin H, IC₅₀: 821 nM		cdk9-cyclin T, IC₅₀: 20 nM									99.37%
AT7519	Cdk1/cyclin B, IC₅₀: 210 nM	cdk2/cyclin A, IC₅₀: 47 nM		Cdk4/cyclin D1, IC₅₀: 100 nM	CDK5/p35, IC₅₀: 13 nM	cdk6/cyclin D3, IC₅₀: 170 nM	CDK7/Cyclin H/MAT1, IC₅₀: 2400 nM		CDK9/Cyclin T, IC₅₀: 10 nM									98.15%
CVT-313	Cdk1/cyclin B, IC₅₀: 4.2 μM	cdk2/cyclin A, IC₅₀: 0.5 μM		Cdk4/cyclin D1, IC₅₀: 215 μM														99.76%
AUZ 454		CDK2(C118L/A144C), Kd: 9.7 nM CDK2(A144C), Kd: 15.4 nM CDK2(C118L), Kd: 18.6 nM CDK2(WT), Kd: 50 nM CDK2(C118L/A144C-Cyclin B), Kd: 134.1 nM																99.99%
JNJ-7706621	Cdk1/cyclin B, IC₅₀: 9 nM	CDK2/cyclinE, IC₅₀: 3 nM cdk2/cyclin A, IC₅₀: 4 nM	CDK3/Cyclin E, IC₅₀: 58 nM	Cdk4/cyclin D1, IC₅₀: 253 nM		CDK6/cyclinD1, IC₅₀: 175 nM												99.91%
Wogonin								CDK8										99.98%
GSK 3 Inhibitor IX	Cdk1/cyclin B, IC₅₀: 320 nM	cdk2/cyclin A, IC₅₀: 300 nM		Cdk4/cyclin D1, IC₅₀: 10 μM	CDK5/p35, IC₅₀: 80 nM													99.66%
CCT-251921								CDK8, IC₅₀: 2.3 nM							CDK19, IC₅₀: 2.6 nM			98.70%
Milciclib	cyclin B/CDK1, IC₅₀: 398 nM	cyclin A/CDK2, IC₅₀: 45 nM cyclin E/CDK2, IC₅₀: 363 nM		cyclin D1/CDK4, IC₅₀: 160 nM			cyclin H/CDK7, IC₅₀: 150 nM											98.61%
Senexin A								CDK8, Kd: 0.83 μM							CDK19, Kd: 0.31 μM			99.93%
PHA-767491 hydrochloride	CDK1, IC₅₀: 250 nM	CDK2, IC₅₀: 240 nM			CDK5, IC₅₀: 460 nM				CDK9, IC₅₀: 34 nM									99.91%
MSC2530818								CDK8, IC₅₀: 2.6 nM										99.59%
OTS964 hydrochloride										CDK11B, Kd: 40 nM								99.05%
LDC000067	cdk1-cyclin B1, IC₅₀: 5513 nM	cdk2-cyclin A, IC₅₀: 2441 nM		cdk4-cyclin D1, IC₅₀: 9242 nM					CDK9- Cyclin T1, IC₅₀: 44 nM									98.14%
Purvalanol A	cdc2-cyclin B, IC₅₀: 4 nM	cdk2-cyclin E, IC₅₀: 35 nM cdk2-cyclin A, IC₅₀: 70 nM		cdk4-cyclin D1, IC₅₀: 850 nM	cdk5-p35, IC₅₀: 75 nM													98.66%
Cucurbitacin E	cyclin B1/CDC2																	99.92%
Trilaciclib hydrochloride				Cdk4/cyclin D1, IC₅₀: 1 nM		cdk6/cyclin D3, IC₅₀: 4 nM												99.24%
Simurosertib																Cdc7, IC₅₀: 0.3 nM		99.07%
CDKI-73	CDK1, IC₅₀: 8.17 nM	CDK2, IC₅₀: 3.27 nM		CDK4, IC₅₀: 8.18 nM		CDK6, IC₅₀: 37.68 nM	CDK7, IC₅₀: 134.26 nM		CDK9, IC₅₀: 5.78 nM									99.58%
R547	Cdk1/cyclin B, Ki: 2 nM	CDK2/cyclinE, Ki: 3 nM		CDK4/cyclin D, Ki: 1 nM														98.42%
BMS-265246	CDK1/cycB, IC₅₀: 6 nM	CDK2/Cyc E, IC₅₀: 9 nM		CDK4/cycD, IC₅₀: 230 nM														97.47%
Atuveciclib	CDK1/CycB(h), IC₅₀: 1100 nM	CDK2/CycE(h), IC₅₀: 1000 nM	CDK3/CycE(h), IC₅₀: 890 nM		CDK5/p35(h), IC₅₀: 1600 nM				CDK9/CycT1, IC₅₀: 13 nM CDK9/CycT1(h), IC₅₀: 6 nM									99.42%
Flavopiridol Hydrochloride	CDK1/Cyc B1, IC₅₀: 30 nM	CDK2/Cyc E, IC₅₀: 170 nM		CDK4/Cyc D1, IC₅₀: 100 nM														99.74%
CC-671																	Clk2, IC₅₀: 0.006 μM	98.86%
LY3177833																Cdc7, IC₅₀: 3.3 nM		99.78%
AT7519 Hydrochloride	Cdk1/cyclin B, IC₅₀: 210 nM	cdk2/cyclin A, IC₅₀: 47 nM		Cdk4/cyclin D1, IC₅₀: 100 nM	CDK5/p35, IC₅₀: 13 nM	cdk6/cyclin D3, IC₅₀: 170 nM	CDK7/Cyclin H/MAT1, IC₅₀: 2400 nM		CDK9/Cyclin T, IC₅₀: 10 nM									99.99%
SU9516	CDK1, IC₅₀: 40 nM	CDK2, IC₅₀: 22 nM		CDK4, IC₅₀: 200 nM														99.76%
KH-CB19																	CLK1, IC₅₀: 19.7 nM CLK3, IC₅₀: 530 nM	99.31%
LY2857785							CDK7, IC₅₀: 0.246 μM	CDK8, IC₅₀: 0.016 μM	CDK9, IC₅₀: 0.011 μM									98.59%
CDK9-IN-1									CDK9/CycT1, IC₅₀: 39 nM									95.48%
NU6300		CDK2, IC₅₀: 0.16 μM																97.03%
PROTAC CDK9 Degrader-1									CDK9									99.04%
Ribociclib hydrochloride				CDK4, IC₅₀: 10 nM		CDK6, IC₅₀: 39 nM												99.83%
XL413 hydrochloride																Cdc7, IC₅₀: 3.4 nM		99.72%
CLK1-IN-1																	CLK1, IC₅₀: 2 nM	99.03%
SEL120-34A monohydrochloride								CDK8/CycC, IC₅₀: 4.4 nM	CDK9/cycT, IC₅₀: 1070 nM						CDK19/CycC, IC₅₀: 10.4 nM			99.98%
ML167																	Clk4, IC₅₀: 136 nM CLK1, IC₅₀: 1522 nM Clk2, IC₅₀: 1648 nM	98.51%
MBQ-167																Cdc42, IC₅₀: 78 nM		99.26%
SEL120-34A HCl								CDK8/CycC, IC₅₀: 4.4 nM	CDK9/cycT, IC₅₀: 1070 nM						CDK19/CycC, IC₅₀: 10.4 nM			99.80%
Lerociclib dihydrochloride	CDK1/cyclinB1, IC₅₀: 2.4 μM	cdk2/cyclin A, IC₅₀: 1.5 μM CDK2/cyclinE, IC₅₀: 3.6 μM		Cdk4/cyclin D1, IC₅₀: 1 nM	CDK5/p35, IC₅₀: 832 nM Cdk5/p25, IC₅₀: 1.2 μM	cdk6/cyclin D3, IC₅₀: 2 nM	CDK7/Cyclin H/MAT1, IC₅₀: 2.4 μM		CDK9/Cyclin T, IC₅₀: 28 nM									98.45%
MC180295	CDK1-Cyclin B, IC₅₀: 138 nM	cdk2-cyclin A, IC₅₀: 233 nM cdk2-cyclin E, IC₅₀: 367 nM	CDK3-Cyclin E, IC₅₀: 399 nM	CDK4-Cyclin D, IC₅₀: 112 nM	cdk5-p35, IC₅₀: 159 nM cdk5-p25, IC₅₀: 186 nM	cdk6-cyclin D3, IC₅₀: 712 nM	CDK7-CycH/MAT1, IC₅₀: 555 nM		CDK9- Cyclin T1, IC₅₀: 5 nM									98.47%
ON123300				Cdk4/cyclin D1, IC₅₀: 3.87 nM		CDK6/cyclinD1, IC₅₀: 9.82 nM
CDK-IN-2									CDK9/cyclinT1, IC₅₀: 8 nM									97.54%
Purvalanol B	cdc2/cyclin B, IC₅₀: 6 nM cyclin dependent kinase 1-cyclinB, IC₅₀: 6 nM	cdk2/cyclin A, IC₅₀: 6 nM CDK2/cyclinE, IC₅₀: 9 nM		Cdk4/cyclin D1, IC₅₀: 10000 nM	CDK5/p35, IC₅₀: 6 nM													>97.0%
FN-1501		cdk2/cyclin A, IC₅₀: 2.47 nM		Cdk4/cyclin D1, IC₅₀: 0.85 nM		CDK6/cyclinD1, IC₅₀: 1.96 nM												98.41%
AMG 925	CDK1, IC₅₀: 1.9 μM	CDK2, IC₅₀: 375 nM		CDK4, IC₅₀: 3 nM		CDK6, IC₅₀: 8 nM												99.33%
BGG463		CDK2																>98.0%
ON-013100				Cdk4/cyclin D1														98.23%
NG 52	cdc2-cyclin B, IC₅₀: 0.34 μM				Pho85p, IC₅₀: 2 nM													99.93%
SY-1365							CDK7
BSJ-03-123						CDK6												99.45%
Longdaysin							CDK7, IC₅₀: 29 μM											99.92%
JSH-150	Cdk1/cyclin B, IC₅₀: 1.34 μM	cdk2/cyclin A, IC₅₀: 2.86 μM			Cdk5/p25, IC₅₀: 4.64 μM		CDK7/Cyclin H/MNAT1, IC₅₀: 1.72 μM		CDK9/cyclinT1, IC₅₀: 1 nM				CDK14/Cyclin Y, IC₅₀: 1.68 μM	CDK16/Cyclin Y, IC₅₀: 292 nM				92.04%
Ribociclib succinate hydrate				CDK4, IC₅₀: 10 nM		CDK6, IC₅₀: 39 nM												99.00%
NVP-LCQ195	Cdk1/cyclin B, IC₅₀: 2 nM	cdk2/cyclin A, IC₅₀: 2 nM CDK2/cyclinE, IC₅₀: 5 nM	CDK3/Cyclin E, IC₅₀: 42 nM		Cdk5/p25, IC₅₀: 1 nM CDK5/p35, IC₅₀: 1 nM	cdk6/cyclin D3, IC₅₀: 187 nM	CDK7/Cyclin H/MAT1, IC₅₀: 3564 nM		CDK9/cyclinT1, IC₅₀: 15 nM									98.99%
CDK8-IN-1								CDK8, IC₅₀: 3 nM										98.62%
Voruciclib hydrochloride	CDK1/cycB, Ki: 5.4 nM CDK1/cyc A, Ki: 9.1 nM			CDK4/Cyc D1, Ki: 3.96 nM		CDK6/cycD1, Ki: 2.92 nM			CDK9/CycT1, Ki: 1.68 nM CDK9/cyc T2, Ki: 0.626 nM									>98.0%
EHT 5372																	CLK1, IC₅₀: 22.8 nM Clk2, IC₅₀: 88.8 nM Clk4, IC₅₀: 59 nM	98.07%
Alsterpaullone	Cdk1/cyclin B, IC₅₀: 35 nM	cdk2/cyclin A, IC₅₀: 15 nM CDK2/Cyc E, IC₅₀: 200 nM			CDK5/p35, IC₅₀: 40 nM													97.30%
CDK4/6-IN-4				CDK4		CDK6
CDK12-IN-3											CDK12, IC₅₀: 491 nM							98.22%
NU2058	CDK1, IC₅₀: 26 μM	CDK2, IC₅₀: 17 μM																99.01%
XL413																Cdc7, IC₅₀: 3.4 nM
AT7519 trifluoroacetate	Cdk1/cyclin B, IC₅₀: 210 nM	cdk2/cyclin A, IC₅₀: 47 nM		Cdk4/cyclin D1, IC₅₀: 100 nM	CDK5/p35, IC₅₀: 13 nM	cdk6/cyclin D3, IC₅₀: 170 nM	CDK7/Cyclin H/MAT1, IC₅₀: 2400 nM		CDK9/Cyclin T, IC₅₀: 10 nM									98.16%
PHA-767491	CDK1, IC₅₀: 250 nM	CDK2, IC₅₀: 240 nM			CDK5, IC₅₀: 460 nM				CDK9, IC₅₀: 34 nM
AMG 925 HCl	CDK1, IC₅₀: 1.9 μM	CDK2, IC₅₀: 375 nM		CDK4, IC₅₀: 3 nM		CDK6, IC₅₀: 8 nM												98.01%
SEL120-34A								CDK8/CycC, IC₅₀: 4.4 nM	CDK9/cycT, IC₅₀: 1070 nM						CDK19/CycC, IC₅₀: 10.4 nM
Roniciclib	Cdk1/cyclin B, IC₅₀: 7 nM	CDK2/cyclinE, IC₅₀: 9 nM		CDK4/cyclin D, IC₅₀: 11 nM			CDK7/Cyclin H/MAT1, IC₅₀: 25 nM		CDK9/cyclinT1, IC₅₀: 5 nM
BS-181 hydrochloride	CDK1/cycB, IC₅₀: 8.1 μM	CDK2/Cyc E, IC₅₀: 0.88 μM		CDK4/Cyc D1, IC₅₀: 33 μM	CDK5/p35NCK, IC₅₀: 3 μM	CDK6/cycD1, IC₅₀: 47 μM	CDK7/CycH/MAT1, IC₅₀: 0.021 μM		CDK9/cycT, IC₅₀: 4.2 μM
JH-XI-10-02								CDK8, IC₅₀: 159 nM
CDK4/6-IN-3	CDK1, Ki: 110 nM			CDK4, Ki: 0.3 nM		CDK6, Ki: 2.2 nM
FMF-04-159-2		CDK2, IC₅₀: 256 nM (in NanoBRET assay)											CDK14/Cyclin Y, IC₅₀: 39.6 nM (in NanoBRET assay)					99.34%
CDK8/19-IN-1								CDK8/CycC, IC₅₀: 0.46 nM	CDK9, IC₅₀: 270 nM						CDK19/CycC, IC₅₀: 0.99 nM
Riviciclib hydrochloride	CDK1-Cyclin B, IC₅₀: 0.079 μM	cdk2-cyclin A, IC₅₀: 0.224 μM cdk2-cyclin E, IC₅₀: 2.500 μM		cdk4-cyclin D1, IC₅₀: 0.063 μM		cdk6-cyclin D3, IC₅₀: 0.396 μM			CDK9- Cyclin T1, IC₅₀: 0.020 μM CDK9-cyclin H, IC₅₀: 2.900 μM									98.33%
PROTAC CDK9 degrader-2									CDK9, IC₅₀: 17 μM (MCF-7 cells)
CDK9-IN-7				CDK4/cyclin D, IC₅₀: 148 nM		CDK6/cyclinD, IC₅₀: 145 nM			CDK9/cyclinT1, IC₅₀: 11 nM
IIIM-290		CDK2/A, IC₅₀: 90 nM							CDK9/T1, IC₅₀: 94 nM
Riviciclib	CDK1-Cyclin B, IC₅₀: 0.079 μM	cdk2-cyclin A, IC₅₀: 0.224 μM cdk2-cyclin E, IC₅₀: 2.540 μM		cdk4-cyclin D1, IC₅₀: 0.063 μM		cdk6-cyclin D3, IC₅₀: 0.396 μM			CDK9- Cyclin T1, IC₅₀: 0.020 μM CDK9-cyclin H, IC₅₀: 2.900 μM
(-)-BAY-1251152									CDK9									99.82%
CDK9-IN-8									CDK9, IC₅₀: 12 nM
SR-4835											CDK12, IC₅₀: 99 nM CDK12, Kd: 98 nM	CDK13, Kd: 4.9 nM
CP-10						CDK6, DC₅₀: 2.1 nM
OTS964										CDK11B, Kd: 40 nM
Bisindolylmaleimide X hydrochloride		CDK2, IC₅₀: 200 nM																98.53%
NU6140	CDK1-Cyclin B, IC₅₀: 6.6 μM	cdk2-cyclin A, IC₅₀: 0.41 μM		CDK4-Cyclin D, IC₅₀: 5.5 μM	cdk5-p25, IC₅₀: 15 μM		cdk7-cyclin H, IC₅₀: 3.9 μM											>99.0%
Lerociclib	CDK1/cyclinB1, IC₅₀: 2.4 μM	cdk2/cyclin A, IC₅₀: 1.5 μM CDK2/cyclinE, IC₅₀: 3.6 μM		Cdk4/cyclin D1, IC₅₀: 1 nM	CDK5/p35, IC₅₀: 0.832 μM Cdk5/p25, IC₅₀: 1.2 μM	cdk6/cyclin D3, IC₅₀: 2 nM	CDK7/Cyclin H/MAT1, IC₅₀: 2.4 μM		CDK9/Cyclin T, IC₅₀: 28 nM
CDK4/6-IN-2				CDK4, IC₅₀: 2.7 nM		CDK6, IC₅₀: 16 nM												99.82%
(2S,3R)-Voruciclib hydrochloride	CDK1			CDK4		CDK6			CDK9
Abemaciclib Metabolites M2				CDK4, IC₅₀: 1-3 nM		CDK6, IC₅₀: 1-3 nM
5-Iodo-indirubin-3'-monoxime	Cdk1/cyclin B, IC₅₀: 25 nM				Cdk5/p25, IC₅₀: 20 nM
Desmethylglycitein	CDK1	CDK2
Nimbolide				CDK4		CDK6
Indirubin-3'-monoxime-5-sulphonic acid	CDK1, IC₅₀: 5 nM				CDK5, IC₅₀: 7 nM
Garcinone C							CDK7
Indirubin-5-sulfonate	Cdk1/cyclin B, IC₅₀: 55 nM	cdk2/cyclin A, IC₅₀: 35 nM CDK2/cyclinE, IC₅₀: 150 nM		Cdk4/cyclin D1, IC₅₀: 300 nM	CDK5/p35, IC₅₀: 65 nM

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