1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK Inhibitors

CDK Inhibitors

CDK1

CDK2

CDK3

CDK4

CDK5

CDK6

CDK7

CDK8

CDK9

CDK12

CDK13

CDK14

CDK16

CDK19

CDC

CLK

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

CDK Inhibitors
Product Name CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Purity
Palbociclib      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                    99.94%
Abemaciclib methanesulfonate
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk4/cyclin D1, IC50: 2 nM
Cdk5/p25, IC50: 355 nM
CDK5/p35, IC50: 287 nM
CDK6/cyclinD1, IC50: 10 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
 
CDK9/cyclinT1, IC50: 57 nM
              99.95%
Ribociclib      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                    99.85%
PF-06873600  
CDK2, Ki: 0.09 nM
 
CDK4, Ki: 0.13 nM
 
CDK6, Ki: 0.16 nM
                    99.98%
SEL120-34A monohydrochloride              
CDK8/CycC, IC50: 4.4 nM
CDK9/cycT, IC50: 1070 nM
       
CDK19/CycC, IC50: 10.4 nM
    99.98%
MC180295
CDK1-Cyclin B, IC50: 138 nM
cdk2-cyclin A, IC50: 233 nM
cdk2-cyclin E, IC50: 367 nM
CDK3-Cyclin E, IC50: 399 nM
CDK4-Cyclin D, IC50: 112 nM
cdk5-p35, IC50: 159 nM
cdk5-p25, IC50: 186 nM
cdk6-cyclin D3, IC50: 712 nM
CDK7-CycH/MAT1, IC50: 555 nM
 
CDK9- Cyclin T1, IC50: 5 nM
              98.47%
THZ531                  
CDK12, IC50: 158 nM
CDK13, IC50: 69 nM
          99.86%
THZ1            
CDK7, IC50: 3.2 nM
                  98.82%
Seliciclib
cdc2/cyclin B, IC50: 0.65 μM
cdk2/cyclin A, IC50: 0.7 μM
Cdk2/cyclin E2, IC50: 0.7 μM
   
CDK5/p35, IC50: 0.16 μM
                      99.94%
NVP-2                
CDK9, IC50: 0.5 nM
              99.29%
Palbociclib isethionate      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                    99.99%
THZ1 Hydrochloride            
CDK7, IC50: 3.2 nM
                  98.70%
CYC065  
CDK2
           
CDK9
              98.58%
Atuveciclib Racemate                
CDK9
              98.48%
Abemaciclib
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk4/cyclin D1, IC50: 2 nM
CDK5/p35, IC50: 287 nM
Cdk5/p25, IC50: 355 nM
CDK6/cyclinD1, IC50: 10 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
 
CDK9/cyclinT1, IC50: 57 nM
              99.69%
AZD4573                
CDK9, IC50: 3 nM
              99.80%
SNS-032
CDK1, IC50: 480 nM
CDK2, IC50: 38 nM
 
CDK4, IC50: 925 nM
   
CDK7, IC50: 62 nM
 
CDK9, IC50: 4 nM
              98.50%
GSK 3 Inhibitor IX
Cdk1/cyclin B, IC50: 320 nM
cdk2/cyclin A, IC50: 300 nM
 
Cdk4/cyclin D1, IC50: 10 μM
CDK5/p35, IC50: 80 nM
                      99.42%
AZD-5438
cdk1-cyclin B1, IC50: 16 nM
cdk2-cyclin E, IC50: 6 nM
cdk2-cyclin A, IC50: 45 nM
 
cdk4-cyclin D1, IC50: 449 nM
cdk5-p25, IC50: 14 nM
cdk6-cyclin D3, IC50: 21 nM
cdk7-cyclin H, IC50: 821 nM
 
cdk9-cyclin T, IC50: 20 nM
              99.84%
CT7001 hydrochloride  
CDK2/cycE1, IC50: 578 nM
       
CDK7/CycH/MAT1, IC50: 41 nM
                  99.98%
Ribociclib succinate      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                    99.93%
CCT-251921              
CDK8, IC50: 2.3 nM
         
CDK19, IC50: 2.6 nM
    98.70%
Milciclib
cyclin B/CDK1, IC50: 398 nM
cyclin A/CDK2, IC50: 45 nM
cyclin E/CDK2, IC50: 363 nM
 
cyclin D1/CDK4, IC50: 160 nM
   
cyclin H/CDK7, IC50: 150 nM
                  98.61%
(+)-BAY-1251152                
CDK9
              99.66%
PHA-767491 hydrochloride
CDK1, IC50: 250 nM
CDK2, IC50: 240 nM
   
CDK5, IC50: 460 nM
     
CDK9, IC50: 34 nM
              99.91%
Wogonin              
CDK8
                99.83%
AUZ 454  
CDK2(C118L/A144C), Kd: 9.7 nM
CDK2(A144C), Kd: 15.4 nM
CDK2(C118L), Kd: 18.6 nM
CDK2(WT), Kd: 50 nM
CDK2(C118L/A144C-Cyclin B), Kd: 134.1 nM
                            99.99%
MSC2530818              
CDK8, IC50: 2.6 nM
                99.59%
JNJ-7706621
Cdk1/cyclin B, IC50: 9 nM
CDK2/cyclinE, IC50: 3 nM
cdk2/cyclin A, IC50: 4 nM
CDK3/Cyclin E, IC50: 58 nM
Cdk4/cyclin D1, IC50: 253 nM
 
CDK6/cyclinD1, IC50: 175 nM
                    98.80%
LDC000067
cdk1-cyclin B1, IC50: 5513 nM
cdk2-cyclin A, IC50: 2441 nM
 
cdk4-cyclin D1, IC50: 9242 nM
       
CDK9- Cyclin T1, IC50: 44 nM
              98.14%
Senexin A              
CDK8, Kd: 0.83 μM
         
CDK19, Kd: 0.31 μM
    99.93%
AT7519 Hydrochloride
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
              99.99%
AT7519
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
              98.15%
Purvalanol A
cdc2-cyclin B, IC50: 4 nM
cdk2-cyclin E, IC50: 35 nM
cdk2-cyclin A, IC50: 70 nM
 
cdk4-cyclin D1, IC50: 850 nM
cdk5-p35, IC50: 75 nM
                      98.66%
CDKI-73
CDK1, IC50: 8.17 nM
CDK2, IC50: 3.27 nM
 
CDK4, IC50: 8.18 nM
 
CDK6, IC50: 37.68 nM
CDK7, IC50: 134.26 nM
 
CDK9, IC50: 5.78 nM
              99.58%
CVT-313
Cdk1/cyclin B, IC50: 4.2 μM
cdk2/cyclin A, IC50: 0.5 μM
 
Cdk4/cyclin D1, IC50: 215 μM
                        99.47%
SU9516
CDK1, IC50: 40 nM
CDK2, IC50: 22 nM
 
CDK4, IC50: 200 nM
                        99.76%
R547
Cdk1/cyclin B, Ki: 2 nM
CDK2/cyclinE, Ki: 3 nM
 
CDK4/cyclin D, Ki: 1 nM
                        98.42%
LY3177833                            
Cdc7, IC50: 3.3 nM
  99.90%
Flavopiridol Hydrochloride
CDK1/Cyc B1, IC50: 30 nM
CDK2/Cyc E, IC50: 170 nM
 
CDK4/Cyc D1, IC50: 100 nM
                        99.00%
LY2857785            
CDK7, IC50: 0.246 μM
CDK8, IC50: 0.016 μM
CDK9, IC50: 0.011 μM
              98.59%
Atuveciclib
CDK1/CycB(h), IC50: 1100 nM
CDK2/CycE(h), IC50: 1000 nM
CDK3/CycE(h), IC50: 890 nM
 
CDK5/p35(h), IC50: 1600 nM
     
CDK9/CycT1, IC50: 13 nM
CDK9/CycT1(h), IC50: 6 nM
              99.42%
Trilaciclib hydrochloride      
Cdk4/cyclin D1, IC50: 1 nM
 
cdk6/cyclin D3, IC50: 4 nM
                    99.24%
CC-671                              
Clk2, IC50: 0.006 μM
98.86%
XL413 hydrochloride                            
Cdc7, IC50: 3.4 nM
  99.76%
Cucurbitacin E
cyclin B1/CDC2
                              99.30%
BMS-265246
CDK1/cycB, IC50: 6 nM
CDK2/Cyc E, IC50: 9 nM
 
CDK4/cycD, IC50: 230 nM
                        97.47%
NU6300  
CDK2, IC50: 0.16 μM
                            97.03%
Ribociclib hydrochloride      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                    99.83%
Simurosertib                            
Cdc7, IC50: 0.3 nM
  99.07%
PROTAC CDK9 Degrader-1                
CDK9
              99.04%
ML167                              
Clk4, IC50: 136 nM
CLK1, IC50: 1522 nM
Clk2, IC50: 1648 nM
98.51%
KH-CB19                              
CLK1, IC50: 19.7 nM
CLK3, IC50: 530 nM
99.45%
CDK9-IN-1                
CDK9/CycT1, IC50: 39 nM
              95.48%
Purvalanol B
cdc2/cyclin B, IC50: 6 nM
cyclin dependent kinase 1-cyclinB, IC50: 6 nM
cdk2/cyclin A, IC50: 6 nM
CDK2/cyclinE, IC50: 9 nM
 
Cdk4/cyclin D1, IC50: 10000 nM
CDK5/p35, IC50: 6 nM
                      >97.0%
SEL120-34A HCl              
CDK8/CycC, IC50: 4.4 nM
CDK9/cycT, IC50: 1070 nM
       
CDK19/CycC, IC50: 10.4 nM
    99.80%
ON123300      
Cdk4/cyclin D1, IC50: 3.87 nM
 
CDK6/cyclinD1, IC50: 9.82 nM
                   
Lerociclib dihydrochloride
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 832 nM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
 
CDK9/Cyclin T, IC50: 28 nM
              98.45%
CDK-IN-2                
CDK9/cyclinT1, IC50: 8 nM
              97.54%
AMG 925
CDK1, IC50: 1.9 μM
CDK2, IC50: 375 nM
 
CDK4, IC50: 3 nM
 
CDK6, IC50: 8 nM
                    99.33%
Ribociclib succinate hydrate      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                    99.00%
NG 52
cdc2-cyclin B, IC50: 0.34 μM
     
Pho85p, IC50: 2 nM
                      99.93%
NVP-LCQ195
Cdk1/cyclin B, IC50: 2 nM
cdk2/cyclin A, IC50: 2 nM
CDK2/cyclinE, IC50: 5 nM
CDK3/Cyclin E, IC50: 42 nM
 
Cdk5/p25, IC50: 1 nM
CDK5/p35, IC50: 1 nM
cdk6/cyclin D3, IC50: 187 nM
CDK7/Cyclin H/MAT1, IC50: 3564 nM
 
CDK9/cyclinT1, IC50: 15 nM
              98.99%
CLK1-IN-1                              
CLK1, IC50: 2 nM
99.03%
MBQ-167                            
Cdc42, IC50: 78 nM
  99.26%
FN-1501  
cdk2/cyclin A, IC50: 2.47 nM
 
Cdk4/cyclin D1, IC50: 0.85 nM
 
CDK6/cyclinD1, IC50: 1.96 nM
                    98.41%
BGG463  
CDK2
                            >98.0%
EHT 5372                              
CLK1, IC50: 22.8 nM
Clk2, IC50: 88.8 nM
Clk4, IC50: 59 nM
NU2058
CDK1, IC50: 26 μM
CDK2, IC50: 17 μM
                            99.01%
XL413                            
Cdc7, IC50: 3.4 nM
 
AT7519 trifluoroacetate
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
              98.16%
AMG 925 HCl
CDK1, IC50: 1.9 μM
CDK2, IC50: 375 nM
 
CDK4, IC50: 3 nM
 
CDK6, IC50: 8 nM
                    98.01%
SEL120-34A              
CDK8/CycC, IC50: 4.4 nM
CDK9/cycT, IC50: 1070 nM
       
CDK19/CycC, IC50: 10.4 nM
   
JSH-150
Cdk1/cyclin B, IC50: 1.34 μM
cdk2/cyclin A, IC50: 2.86 μM
   
Cdk5/p25, IC50: 4.64 μM
 
CDK7/Cyclin H/MNAT1, IC50: 1.72 μM
 
CDK9/cyclinT1, IC50: 1 nM
   
CDK14/Cyclin Y, IC50: 1.68 μM
CDK16/Cyclin Y, IC50: 292 nM
      92.04%
BS-181 hydrochloride
CDK1/cycB, IC50: 8.1 μM
CDK2/Cyc E, IC50: 0.88 μM
 
CDK4/Cyc D1, IC50: 33 μM
CDK5/p35NCK, IC50: 3 μM
CDK6/cycD1, IC50: 47 μM
CDK7/CycH/MAT1, IC50: 0.021 μM
 
CDK9/cycT, IC50: 4.2 μM
             
JH-XI-10-02              
CDK8, IC50: 159 nM
               
CDK8-IN-1              
CDK8, IC50: 3 nM
               
CDK8/19-IN-1              
CDK8/CycC, IC50: 0.46 nM
CDK9, IC50: 270 nM
       
CDK19/CycC, IC50: 0.99 nM
   
Voruciclib hydrochloride
CDK1/cycB, Ki: 5.4 nM
CDK1/cyc A, Ki: 9.1 nM
   
CDK4/Cyc D1, Ki: 3.96 nM
 
CDK6/cycD1, Ki: 2.92 nM
   
CDK9/CycT1, Ki: 1.68 nM
CDK9/cyc T2, Ki: 0.626 nM
             
Riviciclib hydrochloride
CDK1-Cyclin B, IC50: 0.079 μM
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.500 μM
 
cdk4-cyclin D1, IC50: 0.063 μM
 
cdk6-cyclin D3, IC50: 0.396 μM
   
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
             
IIIM-290  
CDK2/A, IC50: 90 nM
           
CDK9/T1, IC50: 94 nM
             
Riviciclib
CDK1-Cyclin B, IC50: 0.079 μM
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.540 μM
 
cdk4-cyclin D1, IC50: 0.063 μM
 
cdk6-cyclin D3, IC50: 0.396 μM
   
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
             
(-)-BAY-1251152                
CDK9
             
CDK9-IN-8                
CDK9, IC50: 12 nM
             
GSK3186899
CRK12
                             
Lerociclib
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 0.832 μM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
 
CDK9/Cyclin T, IC50: 28 nM
             
5-Iodo-indirubin-3'-monoxime
Cdk1/cyclin B, IC50: 25 nM
     
Cdk5/p25, IC50: 20 nM
                     
Indirubin-3'-monoxime-5-sulphonic acid
CDK1, IC50: 5 nM
     
CDK5, IC50: 7 nM
                     
Indirubin-5-sulfonate
Cdk1/cyclin B, IC50: 55 nM
cdk2/cyclin A, IC50: 35 nM
CDK2/cyclinE, IC50: 150 nM
 
Cdk4/cyclin D1, IC50: 300 nM
CDK5/p35, IC50: 65 nM
                     
PHA-767491
CDK1, IC50: 250 nM
CDK2, IC50: 240 nM
   
CDK5, IC50: 460 nM
     
CDK9, IC50: 34 nM
             
Roniciclib
Cdk1/cyclin B, IC50: 7 nM
CDK2/cyclinE, IC50: 9 nM
 
CDK4/cyclin D, IC50: 11 nM
   
CDK7/Cyclin H/MAT1, IC50: 25 nM
 
CDK9/cyclinT1, IC50: 5 nM
             
ON-013100      
Cdk4/cyclin D1