Carbonic Anhydrase
Carbonate dehydratase
Carbonic anhydrase (CA) is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide: CO2 + H2O ⇋ HCO3- + H+. Eight genetically distinct carbonic anhydrase enzyme families (α-, β-, γ- δ-, ζ-, η-, θ- and ι- CAs) were described to date. Carbonic anhydrases are involved in numerous physiological and pathological processes. Many of them are important therapeutic targets with the potential to be inhibited to treat a range of disorders including oedema, glaucoma, obesity, cancer, epilepsy, and osteoporosis.
The carbonic anhydrase reaction is involved in many physiological and pathological processes, including respiration and transport of CO2 and bicarbonate between metabolizing tissues and lungs; pH and CO2 homeostasis; electrolyte secretion in various tissues and organs; biosynthetic reactions (such as gluconeogenesis, lipogenesis, and ureagenesis); bone resorption; calcification; and tumorigenicity. α-CAs are Zn2+ metalloproteins expressed in animals, vertebrates, prokaryotes, fungi, algae, protozoa, and plants. Sixteen mammalian α-CA isoforms are known to be involved in many diseases such as glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, arthritis, neurodegeneration, etc.
Carbonic Anhydrase Isoform Specific Products
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Carbonic Anhydrase
(192)
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CA
(7)
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CA I
(67)
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CA Ⅱ
(119)
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CA IX
(106)
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CA XII
(64)
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CA VII
(1)
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CA VI
(2)
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CA VA
(2)
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CA VB
(2)
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CA XIII
(2)
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CA XIV
(2)
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All Product Categories
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Carbonic Anhydrase Inhibitors
(341)
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Carbonic Anhydrase Activators
(3)
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Carbonic Anhydrase Modulators
(3)
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Carbonic Anhydrase Degrader
(1)
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Carbonic Anhydrase Ligands
(3)
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Carbonic Anhydrase Proteins
(33)
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Carbonic Anhydrase 1 (CA1) Proteins
(1)
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Carbonic Anhydrase 2 (CA-II) Proteins
(3)
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Carbonic Anhydrase 4 (CA IV) Proteins
(3)
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Carbonic Anhydrase 12 (CA-XII) Proteins
(1)
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Carbonic Anhydrase Related Products (377)
Related Products (377)
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Recombinant Proteins (33)
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Carbonic Anhydrase Isoform Comparison
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CA/PRAK-IN-1
0 ImagesCat. No.: HY-184792CA/PRAK-IN-1 is a dual inhibitor of carbonic anhydrase (Carbonic Anhydrase) and PRAK, with a Ki of 20.1 nM against hCA IX and 16.4 nM against hCA XII. CA/PRAK-IN-1 exhibits inhibitory activity against YES1 kinase, BTK, and MAP4K3. CA/PRAK-IN-1 induces G0/G1 phase arrest of the cancer cell cycle, inhibits DNA synthesis, disrupts hypoxia-driven survival pathways, promotes cell death, and shows broad-spectrum cytotoxicity against tumor cells. CA/PRAK-IN-1 can be used in research on various cancers including leukemia, colon cancer, melanoma, and renal cancer.
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CA inhibitor 2
0 ImagesCat. No.: HY-156013CA inhibitor 2 (Compound 4H) is a carbonic anhydrase inhibitor (IC50: 0.033 μM).
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hCAIX-IN-11
0 ImagesCat. No.: HY-147828CAS No.: 2497504-81-9hCAIX-IN-11 (Compound 5d) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 32.7 and 623.5 nM for hCA IX and hCA XII, respectively. hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells.
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hCAIX/XII-IN-6
0 ImagesCat. No.: HY-151472CAS No.: 3031666-31-3hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with Ki values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA).
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CAIX/XII-IN-17
0 ImagesCat. No.: HY-183590CAIX/XII-IN-17 is a selective human carbonic anhydrase IX/XII (CA IX/XII) inhibitor with Ki values of 25.1 nM (hCA IX) and 35.2 nM (hCA XII). CAIX/XII-IN-17 induces apoptosis in pancreatic cancer cells. CAIX/XII-IN-17 can be used for the research of breast cancer, pancreatic cancer.
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hCAIX-IN-6
0 ImagesCat. No.: HY-147663CAS No.: 2451479-86-8Compounds 6b and 14g showed significant inhibitory effect on tumor related subtype HCA IX with low nanomolar potency, while 6k was effective on HCA XII. Compounds 6b, 14g and 6k can be considered as the leading molecules for the development of future cancer therapeutic drugs based on new mechanisms of action.
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L-693612
0 ImagesCat. No.: HY-19213CAS No.: 138301-71-0L-693612 (Compd 1) is an orally active and topical carbonic anhydrase inhibitor.
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Carbonic anhydrase II, Bovine
0 ImagesCat. No.: HY-E71035Carbonic anhydrase II, Bovine (EC 4.2.1.1) catalyzes the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa) , a reversible reaction that occurs relatively slowly in the absence of a catalyst.
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BChE-IN-36
0 ImagesCat. No.: HY-169163hBChE-IN-4 (compound 40) is a potent hCA activator and BChE inhibitor with KA values of 266, 76.9, 918, 893, 98.0 nM for hCA I, hCA II, hCA IV, hCA VB, hCA VII, IC50 values of 72.1, 4.2 nM for eeAChE, eqBChE, respectively. hBChE-IN-4 shows no cytotoxicity. hBChE-IN-4 shows potent procognitive effects. hBChE-IN-4 has the potential for the research of neurodegenerative diseases and other neuropsychiatric disorders.
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hCAII-IN-9
0 ImageshCAII-IN-9 is a potent carbonic anhydrase inhibitor with IC50s of 1.18 μM (hCA II), 0.17 μM (hCA IX), and 2.99 μM (hCA XII), respectively. hCAII-IN-9 has no blood-brain barrier permeability.
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hCAIX-IN-3
0 ImagesCat. No.: HY-146983CAS No.: 2375461-31-5hCAII-IN-3 (compound 7e) is a potent and selective inhibitor of carbonic anhydrase (CA II/IX) with Kis of 124.2 and 30.5 nM, respectively. hCAII-IN-3 has the potential for the research of cancer diseases.
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β-Glucuronidase/hCAII-IN-2
0 ImagesCat. No.: HY-150977CAS No.: 2816080-13-2β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a potent β-glucuronidase and hCA II inhibitor with an IC50 of 670.7 μM and 21.77 μM, respectively.
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Carbonic anhydrase inhibitor 30
0 ImagesCat. No.: HY-172607Carbonic anhydrase inhibitor 30 (compound 17) is an inhibitor of carbonic anhydrase with Ki values of 2.13 μM and 0.161 nM for hCA I and hCA II, respectively[1].
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β-Glucuronidase/hCAII-IN-1
0 ImagesCat. No.: HY-150976CAS No.: 2816080-17-6β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a potent β-glucuronidase and hCA II inhibitor with an IC50 of 440.1 μM and 4.91 μM, respectively.
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hCA-IN-1
0 ImagesCat. No.: HY-175245hCA-IN-1 (Compound 5u) is an hCA inhibitor with Ki values of 159.2, 4.8, 15.5, and 2 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. hCA-IN-1 exhibits broad-spectrum anticancer activity against melanoma, breast, and colon cancer cells. ADME predictions indicate that hCA-IN-1 has good solubility and oral bioavailability. hCA-IN-1 can be used in tumor research.
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(+)-Xylariamide A
0 ImagesCat. No.: HY-126117CAS No.: 852690-88-1(+)-Xylariamide A (compound 6b) is a mycobacterial and fungal carbonic anhydrase probe with inhibitory activity against pathogen β-carbonic anhydrases.
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hCA/VEGFR-2-IN-1
0 ImagesCat. No.: HY-155694hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual Carbonic Anhydrase(CA) IX/XII with Ki values of 4.7 nM and 8.3 nM for hCA XII and hCA IX, respectively. hCA/VEGFR-2-IN-1 (compound 13a) is a potent VEGFR-2 inhibitor with IC50 values 26.3 nM. hCA/VEGFR-2-IN-1 has anticancer activity.
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hCAXII-IN-1
0 ImagesCat. No.: HY-147664CAS No.: 2451479-66-4These compounds show selective inhibition on tumor related subtypes HCA IX and XII, and are also considered as the leading molecules for the development of future cancer therapeutic drugs based on new mechanisms of action.
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hCAIX/XII-IN-11
0 ImagesCat. No.: HY-163414hCAIX/XII-IN-11 (Compound 6c) is an inhibitor of hCA IX and hCA XII with a Ki value of 0.7 μM for both the isoforms. hCAIX/XII-IN-11 can be used for anticancer research.
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Carbonic anhydrase inhibitor 32
0 ImagesCat. No.: HY-172816Carbonic anhydrase inhibitor 32 (compound 5B) is an orally active and selective hCA (Carbonic anhydrase ) II/VII inhibitor with the Ki values of 6.3 nM, 10.1 nM and 681 nM for hCA II, hCA VII and hCA I,respectively. Carbonic anhydrase inhibitor 32 shows neuroprotective and anticonvulsant potential by reducing mTOR activation, and raising hippocampus KCC2 levels.
