2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Carbonic Anhydrase CDK
  4. Carbonic anhydrase inhibitor 14

Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with Ki values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC50 of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity.

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Carbonic anhydrase inhibitor 14 Chemical Structure

Carbonic anhydrase inhibitor 14 Chemical Structure

CAS No. : 2410402-75-2

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Carbonic anhydrase inhibitor 14 Related Antibodies

Top Publications Citing Use of Products

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CA CA I CA Ⅱ CA Ⅸ CA XII

View All CDK Isoform Specific Products:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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Description

Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with Ki values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC50 of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity[1].

IC50 & Target

CDK2

20.3 μM (IC50)

hCA XII

27.7 nM (Ki)

hCA IX

9.4 nM (Ki)

hCA II

99.7 nM (Ki)

hCA I

1203 nM (Ki)

Molecular Weight

395.44

Formula

C18H17N7O2S
CAS No.
SMILES

O=S(C1=CC=C(/N=N/C2=C(NC(C3=CC=C(C)C=C3)=C4)N4N=C2N)C=C1)(N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Carbonic anhydrase inhibitor 14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carbonic anhydrase inhibitor 142410402-75-2Carbonic anhydrase inhibitor14Carbonic anhydrase inhibitor-14Carbonic AnhydraseCDKCarbonate dehydrataseCyclin dependent kinaseantitumorMCF7Inhibitorinhibitorinhibit

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