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Cat. No.: HY-155694

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hCA/VEGFR-2-IN-1

hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual Carbonic Anhydrase(CA) IX/XII with K_i values of 4.7 nM and 8.3 nM for hCA XII and hCA IX, respectively. hCA/VEGFR-2-IN-1 (compound 13a) is a potent VEGFR-2 inhibitor with IC₅₀ values 26.3 nM. hCA/VEGFR-2-IN-1 has anticancer activity.

For research use only. We do not sell to patients.

Formula: C₂₁H₁₇FN₆O₃S
Molecular Weight:452.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

hCA/VEGFR-2-IN-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Carbonic Anhydrase Isoforms :

All VEGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF-10A	IC₅₀	25.58 μM Compound: 13a	Antiproliferative activity against human MCF-10A cells incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF-10A cells incubated for 48 hrs by MTT assay	[PMID: 37501287]
MCF7	IC₅₀	0.66 μM Compound: 13a	Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay	[PMID: 37501287]
T47D	IC₅₀	4.51 μM Compound: 13a	Antiproliferative activity against human T47D cells incubated for 48 hrs by MTT assay Antiproliferative activity against human T47D cells incubated for 48 hrs by MTT assay	[PMID: 37501287]

Chemical Information

Molecular Weight 452.46
Formula C₂₁H₁₇FN₆O₃S
SMILES

O=S(C1=CC=C(C=C1)NC(NC2=NN(C(C3=CC=CC=C3)=N2)C4=CC=C(C=C4)F)=O)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Elsawi AE, et, al. 1,5-Diaryl-1,2,4-triazole Ureas as New SLC-0111 Analogues Endowed with Dual Carbonic Anhydrase and VEGFR-2 Inhibitory Activities. J Med Chem. 2023 Aug 10;66(15):10558-10578. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
Chemical Information
Protocols
Purity & Documentation
References

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hCA/VEGFR-2-IN-1

All Carbonic Anhydrase Isoforms

All VEGFR Isoforms