hCA/VEGFR-2-IN-1
hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual Carbonic Anhydrase(CA) IX/XII with Ki values of 4.7 nM and 8.3 nM for hCA XII and hCA IX, respectively. hCA/VEGFR-2-IN-1 (compound 13a) is a potent VEGFR-2 inhibitor with IC50 values 26.3 nM. hCA/VEGFR-2-IN-1 has anticancer activity.
For research use only. We do not sell to patients.
- Formula: C21H17FN6O3S
- Molecular Weight:452.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All VEGFR Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF-10A | IC50 |
25.58 μM
Compound: 13a
|
Antiproliferative activity against human MCF-10A cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF-10A cells incubated for 48 hrs by MTT assay
|
[PMID: 37501287] |
| MCF7 | IC50 |
0.66 μM
Compound: 13a
|
Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
|
[PMID: 37501287] |
| T47D | IC50 |
4.51 μM
Compound: 13a
|
Antiproliferative activity against human T47D cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human T47D cells incubated for 48 hrs by MTT assay
|
[PMID: 37501287] |
Chemical Information
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Molecular Weight 452.46
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Formula C21H17FN6O3S
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SMILES
O=S(C1=CC=C(C=C1)NC(NC2=NN(C(C3=CC=CC=C3)=N2)C4=CC=C(C=C4)F)=O)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)