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Cat. No.: HY-163414

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hCAIX/XII-IN-11

hCAIX/XII-IN-11 (Compound 6c) is an inhibitor of hCA IX and hCA XII with a K_i value of 0.7 μM for both the isoforms. hCAIX/XII-IN-11 can be used for anticancer research.

For research use only. We do not sell to patients.

Formula: C₁₃H₁₀FN₃O₄
Molecular Weight:291.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

hCAIX/XII-IN-11 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

hCAIX/XII-IN-11 (Compound 6c) is an inhibitor of hCA IX and hCA XII with a K_i value of 0.7 μM for both the isoforms. hCAIX/XII-IN-11 can be used for anticancer research^[1].

IC₅₀ & Target^[1]

hCA XII

0.7 μM (Ki)

hCA IX

0.7 μM (Ki)

All Carbonic Anhydrase Isoforms :

In Vitro

hCAIX/XII-IN-11 shows cytotoxic activity against A549 lung cancer cells, with IC₅₀ value of 81 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 291.23
Formula C₁₃H₁₀FN₃O₄
SMILES

CC1=C(N=NN1C2=CC=C(C=C2)F)C(/C=C(C(O)=O)\O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Siwach K, et al. 1,2,3-Triazole-based esters and carboxylic acids as nonclassical carbonic anhydrase inhibitors capable of cathepsin B inhibition. Arch Pharm (Weinheim). 2024 Mar;357(3):e2300372. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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hCAIX/XII-IN-11

All Carbonic Anhydrase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

hCAIX/XII-IN-11 Related Classifications

HY-163414 Related Classifications