Cholecystokinin Receptor Agonist
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Caerulein
0 ImagesSynonyms: Ceruletide; Cerulein; FI-6934Caerulein is a decapeptide and a potent cholecystokinin receptor agonist. Caerulein is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts.
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CCKBR agonist-2
0 ImagesCCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist. CCKBR agonist-2 effectively activates the CCKBR-Gi signaling pathway (EC50 = 0.27 nM), but has almost no activity on Gq and Gs signaling pathways. CCKBR agonist-2 shows no significant protective effect in the mouse Alzheimer's disease model, proving that the simple activation of the Gi signal pathway does not play a dominant role in the improvement of cognitive function.
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CE-326597
0 ImagesCat. No.: HY-11074CAS No.: 870615-40-0CE-326597 is a small molecule agonist of the cholecystokinin A receptor (CCKAR). CE-326597 occupies only the lower half of the TMD pocket and cannot mimic the crucial interaction between CCK-8 and ECL1-3. CE-326597 can be used to study metabolic diseases and gastrointestinal dysfunction.
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A71378
0 ImagesCat. No.: HY-111918CAS No.: 127902-33-4A71378 is a selectivity CCK-A receptor agonist the IC50 values of 0.4 nM, 300 nM, and 1,200 nM for the pancreatic CCK-A, cortical CCK-B, and gastrin receptor, respectively. A71378 elicits pancreatic amylase secretion (EC50 = 0.16 nM) and ileal muscle contraction (EC50 = 3.7 nM).
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GI 181771
0 ImagesCat. No.: HY-11076CAS No.: 305366-98-7GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity.
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GW-5823
0 ImagesCat. No.: HY-117781CAS No.: 1356689-41-2GW-5823 is a selective CCK-AR agonist with an EC50 of 70 nM. GW-5823 can be studied in research on obesity.
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ARL 15849XX
0 ImagesCat. No.: HY-P1710CAS No.: 152548-39-5ARL 15849XX is a cholecystokinin-8 (CCK-8) analog.
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Caerulein acetate
0 ImagesCat. No.: HY-158722CAS No.: 2760881-68-1Caerulein acetate is a decapeptide and a potent cholecystokinin receptor agonist. Ceruletide acetate is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts.
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JMV 176
0 ImagesCat. No.: HY-P2121CAS No.: 119068-32-5Jmv 176 is a CCK agonist when first given and becomes a cholecystokinin antagonist after 3-4 hours.
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U-67827E
0 ImagesCat. No.: HY-113896CAS No.: 103494-23-1U-67827E is a cholecystokinin (CCK) agonist that decreases food intake over a prolonged period of time in baboons. U-67827E may affect the latency to food by inhibiting the movement of food in the stomach and magnifying a gastric distention signal.
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CCK (26-31) non-sulfated
0 ImagesCat. No.: HY-P2678CAS No.: 89911-64-8CCK (26-31) (non-sulfated) is the N-terminal fragment of CCK, a peptide hormone found in the gut and brain that stimulates digestion, regulates satiety, and is associated with anxiety. CCK (26-31) is also less active in non-sulfated than in sulfated form.
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Cholecystokinin-33 (swine)
0 ImagesCat. No.: HY-P3652CAS No.: 67256-27-3Cholecystokinin-33 (swine) is a cholecystokinin (CCK) fragment. Cholecystokinin-33 (swine) can reduce food intake and gallbladder contraction.
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JMV 170
0 ImagesCat. No.: HY-P1994ACAS No.: 117829-60-4JMV 170, a CCK derivative, is a selective CCK-B agonist. JMV 170 binds to the CCK-B receptor with a 10-fold higher affinity than to the CCK-A receptor. JMV 170 shows contractile effects on pig smooth muscle cells with an EC50 of 9 pmol/L.
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A-70874
0 ImagesCat. No.: HY-129516CAS No.: 131449-37-1A-70874 is a tyrosine-free tetrapeptide analog of cholecystokinin (30-33) (CCK-4). A-70874 is an agonist that stimulates pancreatic amylase release and a partial agonist that stimulates pancreatic phosphoinositide decomposition. A-70874 has an IC50 of 4.9 nM for the guinea pig pancreatic CCK receptor. Cholecystokinin (CCK) receptors are divided into CCK-A (digestive tract) and CCK-B (brain). A-70874 has an affinity of 1.6 μM for the CCK-B/gastrin receptor.
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