2. GPCR/G Protein Neuronal Signaling
  3. Cholecystokinin Receptor
  4. CCKBR agonist-2

CCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist. CCKBR agonist-2 effectively activates the CCKBR-Gi signaling pathway (EC50 = 0.27 nM), but has almost no activity on Gq and Gs signaling pathways. CCKBR agonist-2 shows no significant protective effect in the mouse Alzheimer's disease model, proving that the simple activation of the Gi signal pathway does not play a dominant role in the improvement of cognitive function.

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CCKBR agonist-2

CCKBR agonist-2 Chemical Structure

CAS No. : 923714-61-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

CCKBR agonist-2 Related Antibodies

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Description

CCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist. CCKBR agonist-2 effectively activates the CCKBR-Gi signaling pathway (EC50 = 0.27 nM), but has almost no activity on Gq and Gs signaling pathways. CCKBR agonist-2 shows no significant protective effect in the mouse Alzheimer's disease model, proving that the simple activation of the Gi signal pathway does not play a dominant role in the improvement of cognitive function[1].

Molecular Weight

273.28

Formula

C15H15NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC(OC)=CC(C(NC2=C(C=CC=C2)O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (365.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6593 mL 18.2963 mL 36.5925 mL
5 mM 0.7319 mL 3.6593 mL 7.3185 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6593 mL 18.2963 mL 36.5925 mL 91.4813 mL
5 mM 0.7319 mL 3.6593 mL 7.3185 mL 18.2963 mL
10 mM 0.3659 mL 1.8296 mL 3.6593 mL 9.1481 mL
15 mM 0.2440 mL 1.2198 mL 2.4395 mL 6.0988 mL
20 mM 0.1830 mL 0.9148 mL 1.8296 mL 4.5741 mL
25 mM 0.1464 mL 0.7319 mL 1.4637 mL 3.6593 mL
30 mM 0.1220 mL 0.6099 mL 1.2198 mL 3.0494 mL
40 mM 0.0915 mL 0.4574 mL 0.9148 mL 2.2870 mL
50 mM 0.0732 mL 0.3659 mL 0.7319 mL 1.8296 mL
60 mM 0.0610 mL 0.3049 mL 0.6099 mL 1.5247 mL
80 mM 0.0457 mL 0.2287 mL 0.4574 mL 1.1435 mL
100 mM 0.0366 mL 0.1830 mL 0.3659 mL 0.9148 mL
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CCKBR agonist-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCKBR agonist-2923714-61-8CCKBR agonist2CCKBR agonist 2Cholecystokinin ReceptorCCK ReceptorCCKBRbiased agonismAlzheimer's diseaseG protein-coupled receptorGi signalingstructure-based drug designcryo-EMcognitive impairmentInhibitorinhibitorinhibit

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