923714-61-8
Chemical Structure
CCKBR agonist-2
- CAS No.: 923714-61-8
- Formula:C15H15NO4
- Molecular Weight:273.28
InChIKey: TYQPWPYVBQBXIL-UHFFFAOYSA-N
SMILES: COC1=CC(OC)=CC(C(NC2=C(C=CC=C2)O)=O)=C1
Biological Activity: CCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist. CCKBR agonist-2 effectively activates the CCKBR-Gi signaling pathway (EC50 = 0.27 nM), but has almost no activity on Gq and Gs signaling pathways. CCKBR agonist-2 shows no significant protective effect in the mouse Alzheimer's disease model, proving that the simple activation of the Gi signal pathway does not play a dominant role in the improvement of cognitive function[1].
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CCKBR agonist-2 | 99.81% | CCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist. CCKBR agonist-2 effectively activates the CCKBR-Gi signaling pathway (EC50 = 0.27 nM), but has almost no activity on Gq and Gs signaling pathways. CCKBR agonist-2 shows no significant protective effect in the mouse Alzheimer's disease model, proving that the simple activation of the Gi signal pathway does not play a dominant role in the improvement of cognitive function. | ||||||||||||||||||||
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Keywords
