GI 181771

Cat. No.: HY-11076: Data Sheet Handling Instructions
FAQs
Technical Support

GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity.

For research use only. We do not sell to patients.

GI 181771 Chemical Structure

CAS No. : 305366-98-7

Size	Stock	Quantity
1 mg	Get quote 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

Synthetic products have potential research and development risk.

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 Customer Validation

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Cholecystokinin Receptor Isoform Specific Products:

View All Isoforms

CCKAR CCKBR

Biological Activity
Purity & Documentation
References
Customer Review

Description

GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity.

IC₅₀ & Target

Target: Cholecystokinin 1 receptor^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.8 nM Compound: A, G1181771X	Activity at CCK1R (unknown origin) expressed in CHO cells assessed as stimulation of intracellular calcium responses Activity at CCK1R (unknown origin) expressed in CHO cells assessed as stimulation of intracellular calcium responses	[PMID: 25862198]
CHO	EC₅₀	10 pM Compound: A, G1181771X	Activity at CCK1R (unknown origin) expressed in CHO cells assessed as CCK EC50 measured as intracellular calcium responses at 0.1 nM (Rvb = 7 to 14 pM) Activity at CCK1R (unknown origin) expressed in CHO cells assessed as CCK EC50 measured as intracellular calcium responses at 0.1 nM (Rvb = 7 to 14 pM)	[PMID: 25862198]
CHO	EC₅₀	13 pM Compound: A, G1181771X	Activity at CCK1R (unknown origin) expressed in CHO cells assessed as CCK EC50 measured as intracellular calcium responses at 0.01 nM (Rvb = 7 to 14 pM) Activity at CCK1R (unknown origin) expressed in CHO cells assessed as CCK EC50 measured as intracellular calcium responses at 0.01 nM (Rvb = 7 to 14 pM)	[PMID: 25862198]
CHO	EC₅₀	190 pM Compound: A, G1181771X	Activity at CCK1R (unknown origin) expressed in CHO cells assessed as CCK EC50 measured as intracellular calcium responses at 1 nM (Rvb = 7 to 14 pM) Activity at CCK1R (unknown origin) expressed in CHO cells assessed as CCK EC50 measured as intracellular calcium responses at 1 nM (Rvb = 7 to 14 pM)	[PMID: 25862198]
CHO	EC₅₀	2.4 pM Compound: A, G1181771X	Activity at CCK1R (unknown origin) expressed in CHO cells assessed as CCK EC50 measured as intracellular calcium responses at 0.316 nM (Rvb = 7 to 14 pM) Activity at CCK1R (unknown origin) expressed in CHO cells assessed as CCK EC50 measured as intracellular calcium responses at 0.316 nM (Rvb = 7 to 14 pM)	[PMID: 25862198]
CHO	EC₅₀	283 nM Compound: 1, GI181771X	Agonist activity at human CCK1 receptor expressed in CHO cells assessed as induction of calcium release by FLIPR assay Agonist activity at human CCK1 receptor expressed in CHO cells assessed as induction of calcium release by FLIPR assay	[PMID: 20851601]
CHO	EC₅₀	63.8 nM Compound: 1, GI181771X	Agonist activity at rat CCK1 receptor expressed in CHO cells assessed as induction of calcium release by FLIPR assay Agonist activity at rat CCK1 receptor expressed in CHO cells assessed as induction of calcium release by FLIPR assay	[PMID: 20851601]
CHO	IC₅₀	105 nM Compound: A, G1181771X	Displacement of [125I]CCK from CCK1R (unknown origin) expressed in CHO cells Displacement of [125I]CCK from CCK1R (unknown origin) expressed in CHO cells	[PMID: 25862198]
CHO	IC₅₀	128 nM Compound: A, G1181771X	Displacement of [125I]BDZ1 from CCK1R (unknown origin) expressed in CHO cells Displacement of [125I]BDZ1 from CCK1R (unknown origin) expressed in CHO cells	[PMID: 25862198]
CHO	IC₅₀	131 nM Compound: 1, GI181771X	Displacement of [125I]CCK8 from human CCK1 receptor expressed in CHO cells Displacement of [125I]CCK8 from human CCK1 receptor expressed in CHO cells	[PMID: 20851601]
CHO	IC₅₀	2.7 nM Compound: A, G1181771X	Displacement of [125I]BDZ2 from CCK2R (unknown origin) expressed in CHO cells Displacement of [125I]BDZ2 from CCK2R (unknown origin) expressed in CHO cells	[PMID: 25862198]
CHO	IC₅₀	5.6 nM Compound: A, G1181771X	Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells	[PMID: 25862198]
CHO	IC₅₀	52.6 nM Compound: 1, GI181771X	Displacement of [125I]CCK8 from rat CCK1 receptor expressed in CHO cells Displacement of [125I]CCK8 from rat CCK1 receptor expressed in CHO cells	[PMID: 20851601]

Molecular Weight

605.64

Formula

C₃₄H₃₁N₅O₆

CAS No.

305366-98-7

SMILES

O=C(O)C1=CC=CC(NC(N[C@H]2C(N(CC(N(C(C)C)C3=CC=CC=C3)=O)C4=CC=CC=C4N(C5=CC=CC=C5)C2=O)=O)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Myer JR, et al. Species- and dose-specific pancreatic responses and progression in single- and repeat-dose studies with GI181771X: a novel cholecystokinin 1 receptor agonist in mice, rats, and monkeys. Toxicol Pathol. 2014 Jan;42(1):260-74. [Content Brief]

[2]. Roses AD, et al. Stimulation of cholecystokinin-A receptors with Gl181771X: a failed clinical trial that did not test the pharmacogenetic hypothesis for reduction of food intake. Clin Pharmacol Ther. 2009 Apr;85(4):362-5. [Content Brief]

GI 181771 Related Classifications

Metabolic Disease Endocrinology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GI 181771305366-98-7GI181771GI-181771Cholecystokinin ReceptorCCK ReceptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

GI 181771

Customer Review

GI 181771 Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Cholecystokinin Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

GI 181771 Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report