2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Acyltransferase

Acyltransferase

Diacylglycerol acyltransferase; Diglyceride acyltransferase; acyl-CoA:cholesterol acyltransferase; mono- acylglycerol acyltransferase

Acyltransferase

Related Products

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Acyltransferase (AT) catalyzes the transfer of an acyl moiety from acyl-coenzyme A (acyl-CoA) to an acceptor. Acyltransferases play important roles in the maintenance of homeostasis in the human body and have been linked to various diseases. The Acyltransferase family includes acyl-CoA:cholesterol AT (ACAT), diacylglycerol AT (DGAT), and monoacylglycerol AT (MGAT) for the metabolism of lipids.

ACAT (acyl-coenzyme A:cholesterol acyltransferase) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and fatty acyl-coenzyme A. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles in cellular cholesterol homeostasis in various tissues.

DGAT (acyl-CoA:diacylglycerol acyltransferase) is an integral membrane enzyme that catalyses the last step of triacylglycerol synthesis from diacylglycerol and acyl-CoA. DGAT activity resides mainly in two distinct membrane bound polypeptides, known as DGAT1 and DGAT2.

MGAT (acyl-CoA:monoacylglycerol acyltransferase) catalyzes the synthesis of diacylglycerol, the precursor of physiologically important lipids such as triacylglycerol and phospholipids. In the intestine, MGAT plays a major role in the absorption of dietary fat because resynthesis of triacylglycerol is required for the assembly of lipoproteins that transport absorbed fat to other tissues.

Acyltransferase Isoform Specific Products:

Acyltransferase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108341R
    PF-06424439 (Standard)
    		Inhibitor
    PF-06424439 (Standard) is the analytical standard of PF-06424439 (HY-108341). This product is intended for research and analytical applications. PF-06424439 is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM. PF-06424439 is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate.
    PF-06424439 (Standard)
  • HY-181563
    MGAT2-IN-6
    		Inhibitor
    MGAT2-IN-6 (Compound 23AX) is an orally active MGAT2 inhibitor. MGAT2-IN-6 reduces triglyceride levels and liver fibrosis. MGAT2-IN-6 can be used in the research of metabolic dysfunction-associated fatty liver disease.
    MGAT2-IN-6
  • HY-10038R
    A 922500 (Standard)
    		Inhibitor
    A 922500 (Standard) is the analytical standard of A 922500 (HY-10038). This product is intended for research and analytical applications. A 922500 (DGAT-1 Inhibitor 4a) is a potent, selective, and orally bioavailable diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC50s of 9 and 22 nM against human and mouse DGAT-1, respectively.
    A 922500 (Standard)
  • HY-N14584
    Roselipin 1B
    		Inhibitor
    Roselipin 1B inhibits diacylglycerol acyltransferases (DGAT) of rat hepatic microcosm.
    Roselipin 1B
  • HY-W127668
    Triethylcholine iodide
    		Inhibitor
    Triethylcholine iodide is a choline acetyltransferase inhibitor and a regulator of the acetylcholine synthesis pathway. Triethylcholine iodide inhibits acetylcholine synthesis in brain tissues and blocks neuromuscular and autonomic ganglionic transmission. Triethylcholine iodide exerts weak curare-like effects at extremely high concentrations. Triethylcholine iodide elevates the pentylenetetrazol seizure threshold, alters electroencephalogram patterns in Felis catus, but does not affect the maximal electroshock seizure threshold in Oryctolagus cuniculus. Triethylcholine iodide can be used in seizure-related research.
    Triethylcholine iodide
  • HY-N14573
    Glisoprenin B
    		Inhibitor
    Glisoprenin B is a cholesterol acyltransferase (ACAT) inhibitor.
    Glisoprenin B
  • HY-162094
    CMX410
    		Inhibitor
    CMX410 is an orally active and selective Mycobacterium tuberculosis Pks13 acyltransferase domain inhibitor and anti-bacterial agent. CMX410 reacts with the catalytic serine of the Pks13-AT domain to form a stable β-lactam ring, disables the enzyme’s active site, reduces trehalose monomycolate and trehalose dimycolate levels, triggers cell lysis, and reduces intracellular bacterial burden. CMX410 can be used for the research of tuberculosis.
    CMX410
  • HY-N14580
    Roselipin 2A
    		Inhibitor
    Roselipin 2A inhibits diacylglycerol acyltransferases (DGAT) of rat hepatic microcosm.
    Roselipin 2A
  • HY-N14793
    Amidepsin B
    		Inhibitor
    Amidepsin B is a diacylglycerol acyltransferase (DGAT) inhibitor.
    Amidepsin B
  • HY-N14794
    Amidepsin C
    		Inhibitor
    Amidepsin C is a diacylglycerol acyltransferase (DGAT) inhibitor.
    Amidepsin C
  • HY-N14688
    Phenylpyropene B
    		Inhibitor
    Phenylpyropene B can inhibit ACAT activity with IC50 of 12.8 μM.
    Phenylpyropene B
  • HY-101648
    ACAT-IN-1 cis isomer
    		Inhibitor
    ACAT-IN-1 cis isomer is a potent ACAT inhibitor with an IC50 of 100 nM.
    ACAT-IN-1 cis isomer
  • HY-U00114
    ZSET-845
    		Activator
    ZSET-845 is a cognitive enhancer which enhances choline acetyltransferase activity in the hippocampus in the rat.
    ZSET-845
  • HY-U00369
    FCE 28654
    		Inhibitor
    FCE 28654 is an inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively.
    FCE 28654
Cat. No. Product Name / Synonyms Application Reactivity
Acyltransferase Isoform Comparison

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