2. Signalwege
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Art. -Nr. Produktname Wirkung Reinheit Chemical Structure
  • HY-W357140
    β-Phenylethyl β-D-glucoside
    		Inhibitor
    β-Phenylethyl β-D-glucoside (Phenylethyl β-D-glucopyranoside) (Compound 7), a phenolic compounds, is an antifungal agent. β-Phenylethyl β-D-glucoside can be isolated from the leaves of Piper crocatum. β-Phenylethyl β-D-glucoside has antifungal activity against Candida albicans. β-Phenylethyl β-D-glucoside can be used for fungal infections research.
    β-Phenylethyl β-D-glucoside
  • HY-W008864
    Lactose octaacetate
    		Inhibitor 98.0%
    Lactose octaacetate shows mild to moderate antifungal activity against some fungi, but it has low or no activity against bacteria and yeast. Lactose octaacetate shows low cytotoxicity to MDBK cells, Hep-2 and MDCK cells. Lactose octaacetate has antiviral activity against PV-1.
    Lactose octaacetate
  • HY-108004
    Decamethoxine
    		Inhibitor
    Decamethoxine (Septefril) is a cationic gemini surfactant. Decamethoxine exhibits strong bactericidal and fungicidal effects. Decamethoxine modifies the permeability of the microbial cell membrane, resulting in the destruction and death of diverse microorganisms.
    Decamethoxine
  • HY-126200
    Fenpropidin
    		Inhibitor 99.48%
    Fenpropidin, a piperidine, is a fungicide used to control a range of diseases in cereals. Fenpropidin shows antifungal activity against different human pathogenic yeasts and filamentous fungi.
    Fenpropidin
  • HY-N4283A
    (E)-Coniferyl alcohol
    		Inhibitor 99.62%
    (E)-Coniferyl alcohol is the isomer of Coniferyl alcohol. Coniferyl alcohol is an intermediate in biosynthesis of eugenol and of stilbenoids and coumarin. Coniferyl alcohol specifically inhibits fungal growth.
    (E)-Coniferyl alcohol
  • HY-108012
    ME1111
    		Inhibitor 99.95%
    ME1111 is an antifungal agent that is active against dermatophytes. ME1111 is an inhibitor of the succinate dehydrogenase of Trichophyton species. ME1111 has an excellent ability to penetrate human nails and is used for onychomycosis research.
    ME1111
  • HY-N7684
    Picropodophyllone
    		Inhibitor 99.45%
    Picropodophyllone, an aryltetralin lignan, is isolated from leaves of Podophyllum hexandrum, and has antifungal activities.
    Picropodophyllone
  • HY-B1729R
    Phenoxyethanol (Standard)
    		Inhibitor
    Phenoxyethanol (Standard) is the analytical standard of Phenoxyethanol. This product is intended for research and analytical applications. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al.
    Phenoxyethanol (Standard)
  • HY-U00097
    L-4-Oxalysine hydrochloride
    		Inhibitor 99.95%
    L-4-Oxalysine hydrochloride is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China which has shown antitumor activities.
    L-4-Oxalysine hydrochloride
  • HY-W089856
    Chlorobutanol hemihydrate
    		Inhibitor 99.97%
    Chlorobutanol hemihydrate is an antimicrobial agent with oral activity, also possessing preservative effects. Chlorobutanol hemihydrate exhibits resistance to a variety of Gram-positive and Gram-negative bacteria, as well as several fungal spores and fungi, and is widely used in the food and cosmetics industries.
    Chlorobutanol hemihydrate
  • HY-B0139R
    Flucytosine (Standard)
    		Inhibitor
    Flucytosine (Standard) is the analytical standard of Flucytosine. This product is intended for research and analytical applications. Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells.
    Flucytosine (Standard)
  • HY-B1643
    Ethyl Vanillate
    		Inhibitor 99.87%
    Ethyl Vanillate is a fungicidal agent. Ethyl Vanillate inhibits 17β-HSD2 with an IC50 1.3 µM.
    Ethyl Vanillate
  • HY-W020043
    Pyribencarb
    		Inhibitor 98.80%
    Pyribencarb is a benzylcarbamate-type fungicide, which is active against a wide range of plant pathogenic fungi. Pyribencarb is a potent Qo inhibitor of cytochrome b. Pyribencarb is especially active against Botrytis cinerea and Sclerotinia sclerotirum.
    Pyribencarb
  • HY-123230R
    Trifloxystrobin (Standard)
    		Inhibitor
    Trifloxystrobin (Standard) is the analytical standard of Trifloxystrobin. This product is intended for research and analytical applications. Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases.
    Trifloxystrobin (Standard)
  • HY-W775091
    Isofetamid
    		Inhibitor 99.38%
    Isofetamid (IKF-5411) is a succinate dehydrogenase inhibitor and a fungicide. Isofetamid exhibits good control effects against various fungal diseases such as gray mold, white mold, and powdery mildew. Isofetamid is promising for research of plant fungal diseases.
    Isofetamid
  • HY-B1843
    Fuberidazole
    		Inhibitor 99.87%
    Fuberidazole (BAY 33172; Furidazole) is a fungicide. Fuberidazole shows a synergistic effect with cucurbituril (CB) macromolecules, such as CB7 and CB8. Studies have shown that, CB8 induces pKa shifts on Fuberidazole. Fuberidazole significantly inhibits the growth of B. cinerea.
    Fuberidazole
  • HY-U00007A
    Stilbamidine dihydrochloride
    		Inhibitor
    Stilbamidine dihydrochloride is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections.
    Stilbamidine dihydrochloride
  • HY-N3340
    Macrocarpal I
    		Inhibitor
    Macrocarpal I is a phloroglucinol coupled sesquiterpenoid with antifungal activity. Macrocarpal I against C. glabrata with an IC50 value of 0.75 μg/mL. Macrocarpal I can be isolated from the juvenile leaves of E. maideni.
    Macrocarpal I
  • HY-17006R
    Caspofungin diacetate (Standard)
    		Inhibitor
    Caspofungin (diacetate) (Standard) is the analytical standard of Caspofungin (diacetate). This product is intended for research and analytical applications. Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.
    Caspofungin diacetate (Standard)
  • HY-W654330
    Pyraclostrobin-d6
    		Inhibitor 99.90%
    Pyraclostrobin-d6 is deuterium-labeled Pyraclostrobin (HY-N6626).
    Pyraclostrobin-d<sub>6</sub>
Art. -Nr. Produktname / Synonyms Application Reactivity