L-4-Oxalysine hydrochloride

Name: L-4-Oxalysine hydrochloride
Brand: MedChemExpress
SKU: HY-U00097
Rating: 4.5 (1 reviews)

Cat. No.: HY-U00097 Purity: 99.92%: Data Sheet
COA

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L-4-Oxalysine hydrochloride is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China which has shown antitumor activities.

For research use only. We do not sell to patients.

L-4-Oxalysine hydrochloride Chemical Structure

CAS No. : 118021-35-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Protocol
Purity & Documentation
References
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Description

L-4-Oxalysine hydrochloride is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China which has shown antitumor activities.

In Vitro

Alpha-fetoprotein (AFP) is expressed in BEL-7404 human hepatoma cells and L-4-Oxalysine suppresses AFP mRNA expression in the cells^[1]. L-4-oxalysine functionally antagonizes the a-fetoprotein-induced suppression of the mitogen- and one-way mixed lymphocyte culture-induced proliferation of spleen lymphocytes and interleukin-6 production by these cells in mice bearing the hepatoma-22 tumor^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tbe ultrastructural efects of different doses of L-4-Oxalysine on hepatocytes in mice are most serious at day 1 after stopping treatment. Mice are given ig L-4-oxalysine (I-677) 10, 50, and 100 mg/kg for 7 d. On day 8 the hepatocytes show accumulation of lipid droplets followed by loss of matrices in cytoplasm. The total area of lipid droplets is far less than 25% of mean section of hepatocytes. The injury of mitochondria and RER is only found in the groups of medium and high dose^[1]. L-4-oxalysine inhibits the proliferation of some mouse implanted tumors and pulmonary metastasis of mouse Lewis lung carcinoma^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

184.62

Formula

C₅H₁₃ClN₂O₃

CAS No.

118021-35-5

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](COCCN)C(O)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (541.65 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.4165 mL	27.0827 mL	54.1653 mL
5 mM	1.0833 mL	5.4165 mL	10.8331 mL
10 mM	0.5417 mL	2.7083 mL	5.4165 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.95%

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Data Sheet (271 KB) SDS (394 KB)

COA (244 KB) RP-HPLC (237 KB)

Handling Instructions (2659 KB)

References

[1]. Dai ZQ, et al. Effect of L-4-oxalysine on ultrastructures of liver cells in mice. Zhongguo Yao Li Xue Bao. 1991 Jul;12(4):336-40. [Content Brief]

[2]. Wang XW, et al. Immunostimulatory action of L-4-oxalysine counteracts immunosuppression induced by alpha-fetoprotein. Eur J Pharmacol. 1998 Jun 12;351(1):105-11. [Content Brief]

Animal Administration
^[1]

Mice: Sixty mice are randomly and equally divided into 4 groups. One of the groups is given ig saline and the other are given ig 10, 50, 100 mg /kg for 7d. On day l, 7, 14, and 28 respectively after terminating the treatment, 3 mice of each group are killed and the samples are examined under transmission electron microscope^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Dai ZQ, et al. Effect of L-4-oxalysine on ultrastructures of liver cells in mice. Zhongguo Yao Li Xue Bao. 1991 Jul;12(4):336-40. [Content Brief]

[2]. Wang XW, et al. Immunostimulatory action of L-4-oxalysine counteracts immunosuppression induced by alpha-fetoprotein. Eur J Pharmacol. 1998 Jun 12;351(1):105-11. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.4165 mL	27.0827 mL	54.1653 mL	135.4133 mL
	5 mM	1.0833 mL	5.4165 mL	10.8331 mL	27.0827 mL
	10 mM	0.5417 mL	2.7083 mL	5.4165 mL	13.5413 mL
	15 mM	0.3611 mL	1.8055 mL	3.6110 mL	9.0276 mL
	20 mM	0.2708 mL	1.3541 mL	2.7083 mL	6.7707 mL
	25 mM	0.2167 mL	1.0833 mL	2.1666 mL	5.4165 mL
	30 mM	0.1806 mL	0.9028 mL	1.8055 mL	4.5138 mL
	40 mM	0.1354 mL	0.6771 mL	1.3541 mL	3.3853 mL
	50 mM	0.1083 mL	0.5417 mL	1.0833 mL	2.7083 mL
	60 mM	0.0903 mL	0.4514 mL	0.9028 mL	2.2569 mL
	80 mM	0.0677 mL	0.3385 mL	0.6771 mL	1.6927 mL
	100 mM	0.0542 mL	0.2708 mL	0.5417 mL	1.3541 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.