1. Anti-infection
  2. Fungal
  3. ME1111

ME1111 

Cat. No.: HY-108012
Handling Instructions

ME1111 is an antifungal agent that is active against dermatophytes. ME1111 is an inhibitor of the succinate dehydrogenase of Trichophyton species. ME1111 has an excellent ability to penetrate human nails and is used for onychomycosis research.

For research use only. We do not sell to patients.

ME1111 Chemical Structure

ME1111 Chemical Structure

CAS No. : 1391758-52-3

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Description

ME1111 is an antifungal agent that is active against dermatophytes. ME1111 is an inhibitor of the succinate dehydrogenase of Trichophyton species. ME1111 has an excellent ability to penetrate human nails and is used for onychomycosis research[1][2].

IC50 & Target

dermatophytes[1]

In Vitro

ME1111 inhibits T. mentagrophytes TIMM 2789, with MICs of 0.5 μg/mL and 0.25 μg/mL in RPMI 1640 medium and SDB, respectively[1].
ME1111 mainly affects the permeability of the cell membrane[1].
ME1111 strongly inhibits the succinate-2,6-dichlorophenolindophenol reductase reaction in Trichophyton rubrum and T. mentagrophytes (IC50: 0.029 μg/mL, 0.025 μg/mL) but only shows moderate inhibition of the same reaction in human cell lines[2].

Cell Viability Assay[1]

Cell Line: T. mentagrophytes TIMM 2789
Concentration: 0.125 μg/mL, 0.0625 μg/mL
Incubation Time: 4 hours, 8 hours, 24 hours
Result: Inhibited the hyphal growth in a dose-dependent and time-dependent manner, and induced various morphological alterations.
Molecular Weight

202.25

Formula

C₁₂H₁₄N₂O

CAS No.

1391758-52-3

SMILES

OC1=C(N2N=C(C)C=C2C)C=CC(C)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ME1111ME 1111ME-1111FungalantifungaldermatophytesonychomycosisTrichophytonInhibitorinhibitorinhibit

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ME1111
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