2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W104527
    2,4-Dinitrobenzenesulfonamide
    		Inhibitor
    2,4-Dinitrobenzenesulfonamide (Compound 2d) is an antibacterial and antifungal agent. 2,4-Dinitrobenzenesulfonamide interacts with dihydrofolate synthetase. 2,4-Dinitrobenzenesulfonamide shows inhibitory effect against A. niger, C. albicans, B. subtilis, and S. aureus.
    2,4-Dinitrobenzenesulfonamide
  • HY-B0914R
    10-Undecenoic acid (Standard)
    		Inhibitor
    10-Undecenoic acid (Standard) is the analytical standard of 10-Undecenoic acid. This product is intended for research and analytical applications. 10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa.
    10-Undecenoic acid (Standard)
  • HY-129671
    Polypodine B
    		Inhibitor 98.60%
    Polypodine B is a natural ecdysone ester isolated from the bark of Dacrydium intermedium. Polypodine B significantly inhibits the activity of Acanthamoeba castellani. Polypodine B has moderate antifungal activity. Polypodine B can be used for research on parasitic diseases and fungal infections.
    Polypodine B
  • HY-W012880
    1,2-Hexanediol
    		Inhibitor
    1,2-Hexanediol (Hexane-1,2-diol) is a broad-spectrum antibacterial agent. 1,2-Hexanediol exhibits bactericidal activity against Gram-positive and Gram-negative bacteria, as well as antifungal activity against fungal organisms. 1,2-Hexanediol disrupts the cytoplasmic membrane potential of bacteria. 1,2-Hexanediol can be used in research on bacterial and fungal infections, as well as cosmetic preservation.
    1,2-Hexanediol
  • HY-W021008
    Sotolone
    		Inhibitor
    Sotolone (Dimethylhydroxyfuranone) is an activator of the human olfactory receptor OR8D1. Sotolone activates the human olfactory receptor OR8D1, with EC50 values of 84.98 μM and 167.2 μM for its S-enantiomer and R-enantiomer, respectively. Sotolone has unique aroma profiles: (R)-sotolone exhibits smoky, burnt, herbal and grassy notes; (S)-sotolone presents sweet, milky, sour and nutty notes. Sotolone also acts as an antifungal agent, showing moderate inhibitory activity against Magnaporthe oryzae in vitro.
    Sotolone
  • HY-N0711R
    Carvacrol (Standard)
    		Inhibitor
    Carvacrol (Standard) is the analytical standard of Carvacrol. This product is intended for research and analytical applications. Carvacrol is an orally active and blood-brain barrier-permeable monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations.
    Carvacrol (Standard)
  • HY-W087943
    Methyl octanoate
    		Inhibitor 99.81%
    Methyl octanoate is an ester volatile compound with an odor activity value greater than 1. Methyl octanoate helps impart brandy-like and fruity characteristics to persimmon wine. Methyl octanoate has a strong odor of citrus holly, camphor and menthol. Methyl octanoate can serve as an early marker for grape infection by *Coniella vitis*. Methyl octanoate can be used in studies related to grape white rot.
    Methyl octanoate
  • HY-W005297
    4,6-Dimethoxysalicylaldehyde
    		Inhibitor 99.96%
    4,6-dimethoxysalicylaldehyde is an antifungal agent. 4,6-dimethoxysalicylaldehyde has considerable activity against C. albicans and slight activity against S. cerevisiae.
    4,6-Dimethoxysalicylaldehyde
  • HY-B2064R
    Carboxin (Standard)
    		Inhibitor
    Carboxin (Standard) is the analytical standard of Carboxin. This product is intended for research and analytical applications. Carboxin (Carboxine) is a systemic agricultural fungicide and seed protectant.
    Carboxin (Standard)
  • HY-113542
    Blasticidin A
    		Inhibitor
    Blasticidin A ((+)-Blasticidin A) is a tetraamide acid derivative antibiotic produced by Streptomyces griseochromogenes, as well as a selective inhibitor of aflatoxin production. Blasticidin A exhibits antimicrobial activity against yeast. Blasticidin A can be used in research related to aflatoxin contamination (infection by Aspergillus sp.).
    Blasticidin A
  • HY-128429R
    Trans-​2-​Hexenal (Standard)
    		Inhibitor
    Trans-​2-​Hexenal (Standard) is the analytical standard of Trans-​2-​Hexenal. This product is intended for research and analytical applications. Trans-​2-​Hexenal can be used for the determination of low-molecular-weight carbonyl compounds which are reactive with biological nucleophiles in biological samples.
    Trans-​2-​Hexenal (Standard)
  • HY-119898
    Alloocimene
    		Inhibitor
    Alloocimene is a diterpenoid that activates defense genes and induces resistance to Botrytis cinerea in Arabidopsis thaliana.
    Alloocimene
  • HY-148992
    APX879
    		Inhibitor
    APX879 is a fungal-specific calcineurin inhibitor that has less immunosuppressive activities and toxicities. APX879 is a C22-modified FK506 (HY-13756) analog, which maintains broad-spectrum antifungal activity.
    APX879
  • HY-P2092
    Cyclo(L-leucyl-L-tryptophyl)
    		Inhibitor 99.90%
    Cyclo(L-leucyl-L-tryptophyl) (Cyclo(-Leu-Trp)) is a cyclic dipeptide that inhibits a various of bacteria and fungi. Cyclo(L-leucyl-L-tryptophyl) is a melatonin receptor agonist and is also used as a bitter ligand.
    Cyclo(L-leucyl-L-tryptophyl)
  • HY-U00249
    Saperconazole
    		Inhibitor 99.92%
    Saperconazole (R66905) is a broad-spectrum antifungal triazole and has potent activity against Aspergillus with an MIC90 of 0.19 mg/L.
    Saperconazole
  • HY-133719
    Fenfuram
    		Inhibitor 99.91%
    Fenfuram is an antifungal agent with an EC50 of 6.18 mg/mL against R. solani. Fenfuram can be used in anti-infective research.
    Fenfuram
  • HY-Y0510
    Nitrofungin
    		Inhibitor 99.82%
    Nitrofungin (2-Chloro-4-nitrophenol) is an antifungal agent, and can also be degraded by some bacteria.
    Nitrofungin
  • HY-17395AR
    Terbinafine (Standard)
    		Inhibitor
    Terbinafine (Standard) is the analytical standard of Terbinafine. This product is intended for research and analytical applications. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Terbinafine (Standard)
  • HY-W040305
    2,6-Dichloro-4-nitroaniline
    		Inhibitor ≥99.0%
    2,6-Dichloro-4-nitroaniline is an orally active Herbicide, Fungicide and uncoupler. 2,6-Dichloro-4-nitroaniline uncouples oxidative phosphorylation and inhibits electron transport. 2,6-Dichloro-4-nitroaniline induces biphenyl hydroxylase activity in rat liver. 2,6-Dichloro-4-nitroaniline increases the relative liver weight of rats via hepatomegaly without altering their body weight.
    2,6-Dichloro-4-nitroaniline
  • HY-B0851
    Triadimenol
    		Inhibitor 99.78%
    Triadimenol is a triazole fungicide and has been widely used in agriculture. Triadimenol has certain toxicity to animals.
    Triadimenol
Cat. No. Product Name / Synonyms Application Reactivity