2. Others Metabolic Enzyme/Protease Anti-infection
  3. Fungal Environmental Pollutants Herbicide Mitochondrial Metabolism
  4. 2,6-Dichloro-4-nitroaniline

2,6-Dichloro-4-nitroaniline is an orally active Herbicide, Fungicide and uncoupler. 2,6-Dichloro-4-nitroaniline uncouples oxidative phosphorylation and inhibits electron transport. 2,6-Dichloro-4-nitroaniline induces biphenyl hydroxylase activity in rat liver. 2,6-Dichloro-4-nitroaniline increases the relative liver weight of rats via hepatomegaly without altering their body weight.

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2,6-Dichloro-4-nitroaniline

2,6-Dichloro-4-nitroaniline Chemical Structure

CAS No. : 99-30-9

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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2,6-Dichloro-4-nitroaniline Related Antibodies

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Description

2,6-Dichloro-4-nitroaniline is an orally active Herbicide, Fungicide and uncoupler. 2,6-Dichloro-4-nitroaniline uncouples oxidative phosphorylation and inhibits electron transport. 2,6-Dichloro-4-nitroaniline induces biphenyl hydroxylase activity in rat liver. 2,6-Dichloro-4-nitroaniline increases the relative liver weight of rats via hepatomegaly without altering their body weight[1].

In Vitro

2,6-Dichloro-4-nitroaniline (1×10-5-1×10-4 M) uncouples oxidative phosphorylation and inhibits electron transport in isolated liver mitochondria[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2,6-Dichloro-4-nitroaniline Related Antibodies
In Vivo

2,6-Dichloro-4-nitroaniline (500-1000 mg/kg; p.o.; single dose; administered for 4 consecutive days; up to 12 consecutive weeks) induces hepatomegaly and biphenyl hydroxylase activity in female Sprague-Dawley rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (female, 100-150 g)[1]
Dosage: 500-1000 mg/kg; 1000 mg/kg (single dose); 1000 mg/kg (daily for 4 days); 500 mg/kg (daily for up to 12 weeks)
Administration: p.o.; single dose; daily (4 consecutive days); daily (up to 12 weeks)
Result: Increased hepatic mitochondrial respiratory rate by 18% (16 hours post single 1000 mg/kg dose, succinate as substrate).
Did not alter ADP/O ratio at 1, 16, or 24 hours post single 1000 mg/kg dose.
Increased hepatic 4-OH biphenyl hydroxylase activity to 2.545 μmol/hr/g fresh liver and 2-OH biphenyl hydroxylase activity to 0.513 μmol/hr/g fresh liver (24 hours post single 1000 mg/kg dose).
Increased hepatic mitochondrial respiratory rate to 54.15, 50.94, and 44.53 nmol O2/min/mg protein (1000 mg/kg daily for 2, 3, 4 days respectively, succinate as substrate).
Did not alter ADP/O ratio (1000 mg/kg daily for 2, 3, 4 days).
Increased relative liver weight to 7.10, 7.43, and 6.10 (1000 mg/kg daily for 2, 3, 4 days respectively).
Increased hepatic 4-OH biphenyl hydroxylase activity to 3.705, 5.205, and 4.275 μmol/hr/g fresh liver and 2-OH biphenyl hydroxylase activity to 3.715, 5.181, and 4.385 μmol/hr/g fresh liver (1000 mg/kg daily for 2, 3, 4 days respectively).
Increased relative liver weight to 6.7, 8.1, 6.1, and 5.6 (500 mg/kg daily for 2, 4, 8, 12 weeks respectively).
Increased hepatic 4-OH biphenyl hydroxylase activity to 1.710, 2.27, 1.16, and 3.46 μmol/hr/g fresh liver and 2-OH biphenyl hydroxylase activity to 2.378, 1.48, 1.05, and 4.45 μmol/hr/g fresh liver (500 mg/kg daily for 2, 4, 8, 12 weeks respectively).
Elevated respiratory activity in 33,000 g·min heavy mitochondrial pellet throughout 3 months of 500 mg/kg daily treatment.
Detected ~1×10-5 M DCNA in whole liver homogenate and crude nuclear pellet (500 mg/kg daily for 4 days).
Detected 37.2 μg/mL DCNA in urine (single 1000 mg/kg dose) and 30.6 μg/mL DCNA in urine (500 mg/kg daily for 30 days).
Molecular Weight

207.01

Formula

C6H4Cl2N2O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

ClC(C=C1[N+]([O-])=O)=C(C(Cl)=C1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (80.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8307 mL 24.1534 mL 48.3068 mL
5 mM 0.9661 mL 4.8307 mL 9.6614 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (789 KB)

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8307 mL 24.1534 mL 48.3068 mL 120.7671 mL
5 mM 0.9661 mL 4.8307 mL 9.6614 mL 24.1534 mL
10 mM 0.4831 mL 2.4153 mL 4.8307 mL 12.0767 mL
15 mM 0.3220 mL 1.6102 mL 3.2205 mL 8.0511 mL
20 mM 0.2415 mL 1.2077 mL 2.4153 mL 6.0384 mL
25 mM 0.1932 mL 0.9661 mL 1.9323 mL 4.8307 mL
30 mM 0.1610 mL 0.8051 mL 1.6102 mL 4.0256 mL
40 mM 0.1208 mL 0.6038 mL 1.2077 mL 3.0192 mL
50 mM 0.0966 mL 0.4831 mL 0.9661 mL 2.4153 mL
60 mM 0.0805 mL 0.4026 mL 0.8051 mL 2.0128 mL
80 mM 0.0604 mL 0.3019 mL 0.6038 mL 1.5096 mL
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2,6-Dichloro-4-nitroaniline Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,6-Dichloro-4-nitroaniline99-30-9FungalEnvironmental PollutantsHerbicideMitochondrial MetabolismEnvironmental Contaminantsdrug-processing enzymeselectron transportratshepatic lysosomesmooth endoplasmic reticulummicrosomal hydroxylationoxidative phosphorylationhepatic mitochondriarespiratory enzymesbiphenyl hydroxylaseInhibitorinhibitorinhibit

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