Sotolone (Synonyms: Dimethylhydroxyfuranone)

Cat. No.: HY-W021008 Purity: ≥95.0%: Data Sheet
COA

SDS
Handling Instructions
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Sotolone (Dimethylhydroxyfuranone) is an activator of the human olfactory receptor OR8D1. Sotolone activates the human olfactory receptor OR8D1, with EC₅₀ values of 84.98 μM and 167.2 μM for its S-enantiomer and R-enantiomer, respectively. Sotolone has unique aroma profiles: (R)-sotolone exhibits smoky, burnt, herbal and grassy notes; (S)-sotolone presents sweet, milky, sour and nutty notes. Sotolone also acts as an antifungal agent, showing moderate inhibitory activity against Magnaporthe oryzae in vitro.

For research use only. We do not sell to patients.

Sotolone Chemical Structure

CAS No. : 28664-35-9

Size	Stock	Quantity
50 mg	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 mg	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 mg	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

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Other Forms of Sotolone:

4,5-Dimethyl-3-hydroxy-2(5H)-furanone-¹³C₂ In-stock
Sotolone-d₂ Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Sotolone (200 µg/mL; 2-6 days) exhibits weak to moderate in vitro inhibitory activity against Magnaporthe oryzae BV, Sclerotium rolfsii, and Phytophthora capsici, with IC₅₀ values of 256.0 µg/mL, 333.7 µg/mL, and 279.2 µg/mL respectively, and weaker activity against other tested phytopathogenic fungi^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

128.13

Formula

C₆H₈O₃

CAS No.

28664-35-9

Appearance

Liquid (Density: 1.049 g/cm³)

Color

Colorless to light yellow

SMILES

O=C1OC(C(=C1O)C)C

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (780.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.8046 mL	39.0229 mL	78.0457 mL
5 mM	1.5609 mL	7.8046 mL	15.6091 mL
10 mM	0.7805 mL	3.9023 mL	7.8046 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (251 KB) HNMR (244 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Wang J, et al. Decoding Molecular Mechanism Underlying Human Olfactory Receptor OR8D1 Activation by Sotolone Enantiomers. J Agric Food Chem. 2024;72(10):5403-5415. [Content Brief]

[2]. Le Dang Q, et al. In vitro and in vivo antimicrobial activities of extracts and constituents derived from Desmodium styracifolium (Osb.) Merr. against various phytopathogenic fungi and bacteria. Industrial Crops and Products. 2022 Nov 15;188:115521.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.8046 mL	39.0229 mL	78.0457 mL	195.1143 mL
	5 mM	1.5609 mL	7.8046 mL	15.6091 mL	39.0229 mL
	10 mM	0.7805 mL	3.9023 mL	7.8046 mL	19.5114 mL
	15 mM	0.5203 mL	2.6015 mL	5.2030 mL	13.0076 mL
	20 mM	0.3902 mL	1.9511 mL	3.9023 mL	9.7557 mL
	25 mM	0.3122 mL	1.5609 mL	3.1218 mL	7.8046 mL
	30 mM	0.2602 mL	1.3008 mL	2.6015 mL	6.5038 mL
	40 mM	0.1951 mL	0.9756 mL	1.9511 mL	4.8779 mL
	50 mM	0.1561 mL	0.7805 mL	1.5609 mL	3.9023 mL
	60 mM	0.1301 mL	0.6504 mL	1.3008 mL	3.2519 mL
	80 mM	0.0976 mL	0.4878 mL	0.9756 mL	2.4389 mL
	100 mM	0.0780 mL	0.3902 mL	0.7805 mL	1.9511 mL

Sotolone Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sotolone28664-35-9DimethylhydroxyfuranoneFungalV108³·³⁶Sclerotium rolfsiiF104³·³²Phytophthora capsiciOR8D1N206⁵·⁴⁶Magnaporthe oryzae BVHEK293 cellsrice seedlingsV109³·³⁷Inhibitorinhibitorinhibit

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