28664-35-9
Chemical Structure
Sotolone
Synonym(s): Dimethylhydroxyfuranone
- CAS No.: 28664-35-9
- Formula:C6H8O3
- Molecular Weight:128.13
IUPAC Name: 3-hydroxy-4,5-dimethylfuran-2(5H)-one
InChIKey: UNYNVICDCJHOPO-UHFFFAOYSA-N
SMILES: O=C1OC(C(=C1O)C)C
Biological Activity: Sotolone (Dimethylhydroxyfuranone) is an activator of the human olfactory receptor OR8D1. Sotolone activates the human olfactory receptor OR8D1, with EC50 values of 84.98 μM and 167.2 μM for its S-enantiomer and R-enantiomer, respectively. Sotolone has unique aroma profiles: (R)-sotolone exhibits smoky, burnt, herbal and grassy notes; (S)-sotolone presents sweet, milky, sour and nutty notes. Sotolone also acts as an antifungal agent, showing moderate inhibitory activity against Magnaporthe oryzae in vitro[1][2].
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Sotolone | ≥95.0% | Sotolone (Dimethylhydroxyfuranone) is an activator of the human olfactory receptor OR8D1. Sotolone activates the human olfactory receptor OR8D1, with EC50 values of 84.98 μM and 167.2 μM for its S-enantiomer and R-enantiomer, respectively. Sotolone has unique aroma profiles: (R)-sotolone exhibits smoky, burnt, herbal and grassy notes; (S)-sotolone presents sweet, milky, sour and nutty notes. Sotolone also acts as an antifungal agent, showing moderate inhibitory activity against Magnaporthe oryzae in vitro. | ||||||||||||||||||||
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4,5-Dimethyl-3-hydroxy-2(5H)-furanone-13C2 | 4,5-Dimethyl-3-hydroxy-2(5H)-furanone-13C2 is 13C labeled 4,5-Dimethyl-3-hydroxy-2(5H)-furanone-13C2. | |||||||||||||||||||||
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References
- [1]. Wang J, et al. Decoding Molecular Mechanism Underlying Human Olfactory Receptor OR8D1 Activation by Sotolone Enantiomers. J Agric Food Chem. 2024;72(10):5403-5415. [Content Brief]
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[2]. Le Dang Q, et al. In vitro and in vivo antimicrobial activities of extracts and constituents derived from Desmodium styracifolium (Osb.) Merr. against various phytopathogenic fungi and bacteria. Industrial Crops and Products. 2022 Nov 15;188:115521.
