2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glycosidase

Glycosidase

Glycosidase

Glycosidase

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Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156078
    α-Glucosidase-IN-32
    		Inhibitor
    α-Glucosidase-IN-32 (compound f26) is a reversible, noncompetitive and orally active α-glucosidase inhibitor with an IC50 value of 3.07 μM. α-Glucosidase-IN-32 complex with α-glucosidase through hydrogen bonds and hydrophobic interactions, led to changes in the conformation and secondary strictures of α-glucosidase and further the inhibition of the enzymatic activity. α-Glucosidase-IN-32 can be used for diabetic disease research.
    α-Glucosidase-IN-32
  • HY-135670B
    Glycosidase-IN-2
    		Inhibitor
    Glycosidase-IN-2 (Compound 20) is an azasugar class of glycosidase inhibitor. Glycosidase-IN-2 has hypoglycemic activity.
    Glycosidase-IN-2
  • HY-181469
    C2 Adamantanyl glucosylceramide (d18:1/2:0)
    		Inhibitor
    C2 Adamantanyl glucosylceramide (d18:1/2:0) (Adamantanyl GluCer (d18:1/2:0)) is an inhibitor of glucocerebrosidase (GCC) and LacCer synthase. At low doses, C2 Adamantanyl glucosylceramide (d18:1/2:0) increases intracellular glycolipid levels by inhibiting glucocerebrosidase. C2 Adamantanyl glucosylceramide (d18:1/2:0) alters glycolipid metabolism. C2 Adamantanyl glucosylceramide (d18:1/2:0) can be used for the research of Gaucher disease and Fabry disease.
    C2 Adamantanyl glucosylceramide (d18:1/2:0)
  • HY-E71169
    1,6-α-L-Fucosidase
    1,6-α-L-Fucosidase (EC 3.2.1.127) belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds.
    1,6-α-L-Fucosidase
  • HY-W740650
    Migalastat hydrochloride-15N
    Migalastat hydrochloride-15N (GR181413A-15N) is the 15N-labeled Migalastat hydrochloride (HY-14929A). Migalastat (GR181413A free base) hydrochloride is an orally active α-galactosidase A molecular chaperone, with an IC50 value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity.
    Migalastat hydrochloride-<sup>15</sup>N
  • HY-N19811
    Eleuthoside B
    		Control
    Eleuthoside B is a naphthyl gentiobioside identified from the bulbs of Eleutherine americana. Eleuthoside B has an IC50 >1.00 mM against α-glucosidase, and it is not the main contributor to the antidiabetic (hypoglycemic) activity exhibited by the plant extract.
    Eleuthoside B
  • HY-174319
    α-Amylase/α-Glucosidase-IN-20
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-20 (Compound 6b) is a dual inhibitor of α-Amylase and α-Glucosidase with IC50s of 414.57 and 924.15 μM for α-Amylase and α-Glucosidase, respectively. α-Amylase/α-Glucosidase-IN-20 shows a potent anti-diabetic activity, promising for diabetes research.
    α-Amylase/α-Glucosidase-IN-20
  • HY-155030
    α-Glucosidase-IN-25
    		Inhibitor
    α-Glucosidase-IN-25 (Compound (R)-8k) is a competitive inhibitor of α-glucosidase, with an IC50 of 1.19μM and can be used for anti-diabetic research.
    α-Glucosidase-IN-25
  • HY-178216
    Glycosidase-IN-3
    		Inhibitor
    Glycosidase-IN-3 (example 92) is a pyrimidine compound targeting beta-glucocerebrosidase, which can be used in the research of related diseases such as Gaucher's disease and Parkinson's disease.
    Glycosidase-IN-3
  • HY-163907
    α-Glucosidase-IN-71
    		Inhibitor
    α-Glucosidase-IN-71 (Compound 7h) is a competitive α-glucosidase inhibitor (IC50: 98.0 µM). α-Glucosidase-IN-71 can be used for research of carbohydrate-related diseases, especially type 2 diabetes mellitus.
    α-Glucosidase-IN-71
  • HY-N12761
    Penpaxilloids A
    		Inhibitor
    Penpaxilloids A (Compound 1) is a non-competitive inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 8.60 μM. Penpaxilloids A can be isolated from the fungus Penicillium sp. ZYX-Z-143. Penpaxilloids A is also an α-glucosidase (α-glucosidase) inhibitor with anti-inflammatory activity.
    Penpaxilloids A
  • HY-165424
    NIR-BG2
    		Inhibitor
    NIR-BG2 is a near-infrared fluorescent probe targeting senescence-associated β-galactosidase (SA-β-Gal). NIR-BG2 is activated by SA-β-Gal and undergoes hydrolysis to release electrophilic quinone methide that covalently binds to surrounding proteins for in situ labeling, with a 16-fold enhancement of fluorescence signal at 709 nm . NIR-BG2 is promising for research of vivo imaging of cellular senescence.
    NIR-BG2
  • HY-150961
    α-Glucosidase-IN-14
    		Inhibitor
    α-Glucosidase-IN-14 (compound 5) is a potent α-glucosidase inhibitor, with an IC50 of 5.22 μM.
    α-Glucosidase-IN-14
  • HY-E71299
    β-Galactosidase 42A, Bifidobacterium longum
    β-Galactosidase 42A, Bifidobacterium longum (EC 3.2.1.23) is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.
    β-Galactosidase 42A, Bifidobacterium longum
  • HY-P2775B
    β-Glucosidase, Rhizobium etli
    β-Glucosidase, Rhizobium etli (EC 3.2.1.21), is a glucosidase that acts on the β1→4 glycosidic bond connecting two glucose molecules or glucose-substituted molecules (e.g., disaccharide cellobiose). β-Glucosidase is an exonuclease specific for a variety of β-D-glycosidic substrates. β-Glucosidase catalyzes the hydrolysis of the terminal non-reducing residues of β-D-glucosides, releasing glucose.
    β-Glucosidase, Rhizobium etli
  • HY-E71316
    β-Mannanase 76A, Bacteroides thetaiotaomicron
    β-Mannanase 76A, Bacteroides thetaiotaomicron (EC 3.2.1.78) is an enzyme with system name 4-beta-D-mannan mannanohydrolase. This enzyme catalyses the following chemical reaction: Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.
    β-Mannanase 76A, Bacteroides thetaiotaomicron
  • HY-E70887
    Broad-specificity fucosidase O
    Broad-specificity fucosidase O (FucO) is a α-fucosidase that can efficiently remove α1-6- and α1-3-linked core fucose from N-glycans.
    Broad-specificity fucosidase O
  • HY-N16668
    (3R,5S)-5'-Methoxyoctahydrocurcumin
    		Inhibitor
    (3R,5S)-5'-Methoxyoctahydrocurcumin (Compound 4) is a diarylheptanoidfound in Curcuma comosa. (3R,5S)-5'-Methoxyoctahydrocurcumin exhibits strong antiallergic activity by inhibiting β-hexosaminidase release and the degranulation of mast cells. (3R,5S)-5'-Methoxyoctahydrocurcumin can be used for the research of immunology, such as asthma.
    (3R,5S)-5'-Methoxyoctahydrocurcumin
  • HY-W127945
    N-(E)-Caffeoyldopamine
    		Inhibitor
    N-(E)-Caffeoyldopamine is an inhibitor of α-glucosidase that can be purified from Clerodendranthus Spicatus. N-(E)-Caffeoyldopamine shows a 53.73% inhibitory activity againstα-glucosidase. N-(E)-Caffeoyldopamine can be studied in diabetes research.
    N-(E)-Caffeoyldopamine
  • HY-E71305I
    β-Glucosidase 1A, Thermobifida fusca
    β-Glucosidase 1A, Thermobifida fusca (EC 3.2.1.21) is a glucosidase enzyme that acts upon β1->4 bonds linking two glucose or glucose-substituted molecules (i.e., the disaccharide cellobiose) . β-Glucosidase is one of the cellulases, enzymes involved in the decomposition of cellulose and related polysaccharides; more specifically, an exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of glucose.
    β-Glucosidase 1A, Thermobifida fusca
Cat. No. Product Name / Synonyms Application Reactivity