Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome 関連製品 (1006):

By Effects:	Inhibitors (2) Controls (2) Substrate (1) Modulator (1) Chemicals (8)

製品番号	製品名	製品効果	純度	構造式

HY-172711A

DSPE-PEG3400-R6H4
DSPE-PEG3400-R6H4 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (R6H4). R6H4 can be used for pH responsive anticancer drug delivery purposes. DSPE-PEG3400-R6H4 can be used for drug delivery.

HY-167016

Cholesterol-undecanoate-glucose conjugate
Cholesterol-undecanoate-glucose conjugate is a cholesterol conjugate used in the synthesis of intranasal liposomal vaccines. Cholesterol-undecanoate-glucose conjugate can be used in drug delivery studies.

HY-177204A

DSPE-PEG1000-WLSEAGPVVTVRALRGTGSW
DSPE-PEG1000-WLSEAGPVVTVRALRGTGSW is a PEG compound which composed of DSPE and a cardiomyocyte specific peptide (WLSEAGPVVTVRALRGTGSW) (HY-P3436). WLSEAGPVVTVRALRGTGSW exhibits high cardiomyocyte targeting primarily through selective binding to specific receptors or molecules on the surface of cardiomyocytes. DSPE-PEG1000-WLSEAGPVVTVRALRGTGSW can be used for drug delivery.

HY-172493

DSPE-PEG1000-iRGD
DSPE-PEG1000-iRGD is a PEG compound which composed of DSPE and an αv-integrins targeting peptide (iRGD). iRGD peptide binds to αv-integrins, and then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. DSPE-PEG1000-iRGD can be used for drug delivery.

HY-172727

DSPE-PEG5000-EB1
DSPE-PEG5000-EB1 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (EB1). DSPE-PEG5000-EB1 can be used for drug delivery.

HY-155931

18:1 PEG550 PE ammonium
18:1 PEG550 PE ammonium (DOPE-PEG550 ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-126356S

1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d₁₁
1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d₁₁ is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (HY-126356). 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine is a major phospholipid in low-density lipoprotein and belongs to the group of 1-acyl phosphatidylcholines. 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine does not induce morphological changes in washed human platelets. 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine can be used for the research of atherosclerosis and thrombotic diseases.

HY-145797

L343
L343 is an ionizable cationic lipidoid and can be used to synthetic liposomes for systemic delivery of RNAi therapeutics.

HY-172713

DSPE-PEG1000-MPG
DSPE-PEG1000-MPG is a PEG compound which composed of DSPE and a peptide vector (MPG). MPG is derived from both the nuclear localisation sequence (NLS) of SV40 large T antigen and the fusion peptide domain of HIV-1 gp41. MPG could deliver short oligonucleotides into cells efficiently and independently of the endosomal pathway.

HY-143204

(Rac)-POPC
(Rac)-POPC is a model phosphatidylcholine for the preparation of giant vesicles (GVs).

HY-144013B

18:0 mPEG550 PE ammonium
18:0 mPEG550 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-172475

DSPE-PEG1000-YIGSR
DSPE-PEG1000-YIGSR is a PEG compound which composed of DSPE and a biomimetic peptide YIGSR. YIGSR interacts with the 67 kDa laminin binding protein (LBP) and promotes adhesion and spreading of a large number of cell types including endothelial cells, fibroblasts and smooth muscle cells. DSPE-PEG1000-YIGSR can be used for drug delivery.

HY-182098B

DSPE-PEG3400-GALA
DSPE-PEG3400-GALA is a PEG compound which composed of DSPE and a lung endothelium-targeting peptide GALA (HY-P5423). GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. DSPE-PEG3400-GALA can be used for drug delivery.

HY-172280A

DSPE-PEG2000-octreotide
DSPE-PEG21000-Octreotide is a PEG compound which composed of DSPE and a Octreotide (HY-P0036). Octreotide is a somatostatin receptor agonist. Octreotide has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly. DSPE-PEG2000-Octreotide can be used for drug delivery.

HY-172332

H1L1A1B3
H1L1A1B3 is an ionizable cationic lipid used in the formation of lipid nanoparticles (LNPs) for the delivery of circular RNA (circRNA). H1L1A1B3-LNPs demonstrates a fourfold increase in circRNA transfection efficiency in lung cancer cells over ALC-0315 (HY-138170). H1L1A1B3 can activate the NF-κB/IRF immune pathways.

HY-W440683

C13-112-tetra-tail
C13-112-tetra-tail is a cationic lipid-like compound containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a PEG2 linker. C13-112-tetra-tail can be formulated into a lipid nanoparticle (LNP).

HY-172466

DSPE-PEG1000-CTT2
DSPE-PEG1000-CTT2 is a PEG compound which composed of DSPE and a gelatinase inhibitor (CTT2 (CTTHWGFTLC)). CTT2 (CTTHWGFTLC) has the ability to specifically target tumors. DSPE-PEG1000-CTT2 can be used for drug delivery.

HY-W127349

Cholesterol n-Octanoate		98.0%
Cholesterol n-Octanoate is an organic compound belonging to the class of esters. It is formed from the reaction between cholesterol and caprylic acid. Cholesterol n-octanoate has various applications in the pharmaceutical industry, notably as a bioactive compound with potential research potential to improve a range of medical conditions, such as high cholesterol and inflammation-related diseases. Additionally, it has potential applications as a food additive to improve texture and stability.

HY-W440957

PMPC
PMPC is a phosphatidylcholine with asymmetrical fatty acid. Palmitic acid occupies sn-1 position while myristic acid is placed at the sn-2 position.

HY-112005GL

DOPE (GMP Like)
DOPE (GMP Like) is the GMP Like class DOPE (HY-112005), and can be used as pharmaceutical excipients. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOPE is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA.

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