2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health[1][2][3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets[1][2][3].

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-116001
    (+)-Carbovir
    (+)-Carbovir (NSC 614846) is an antiviral drug with activity against human immunodeficiency virus type 1. (+)-Carbovir is a nucleoside analog with enhanced chemical and metabolic stability. (+)-Carbovir can be used in AIDS research.
    (+)-Carbovir
  • HY-123347
    TPU-0037C
    TPU-0037C is a metabolite of the marine actinomycete S. platensis that is structurally similar to Lydicamycin (HY-125414). It is active against Gram-positive bacteria (MICs=0.39-3.13 μg/mL), including methicillin-resistant S. aureus strains (MIC=3.13 μg/mL), but is ineffective against Gram-negative bacteria (MICs=>50 μg/mL).
    TPU-0037C
  • HY-N19641
    Dichlorodiaporthin
    Dichlorodiaporthin (Dichlorodiaportin) is an isocoumarin metabolite found in cultures of Penicillium nalgiovense. Dichlorodiaporthin acts as an antibacterial agent against various bacterial species.
    Dichlorodiaporthin
  • HY-18957C
    Lifirafenib hydrochloride
    Lifirafenib hydrochloride (BGB-283 hydrochloride) is a novel, reversible B-RAFV600E inhibitor with antitumor activity. Lifirafenib has shown potent antitumor activity against solid tumors with B-RAFV600E mutations, such as melanoma, thyroid cancer, and low-grade serous ovarian cancer. Lifirafenib exhibits selective cytotoxicity in vitro, preferentially inhibiting the proliferation of cancer cells with B-RAFV600E and EGFR mutations/amplification. Lifirafenib can achieve dose-dependent inhibition of tumor growth in animal models, accompanied by partial and complete tumor shrinkage.
    Lifirafenib hydrochloride
  • HY-A0181S4
    Adenosine monophosphate-13C10,15N5,d12 dilithium
    Adenosine monophosphate-13C10,15N5,d12 (AMP-13C10,15N5,d12) dilithium is 13C and 15N-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
    Adenosine monophosphate-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub>,d<sub>12</sub> dilithium
  • HY-W014504S1
    DL-Kynurenine-d7
    DL-Kynurenine-d7 is the deuterium labeled DL-Kynurenine. DL-Kynurenine is a key metabolite in the tryptophan metabolic pathway and can cross the blood-brain barrier. DL-Kynurenine has a bidirectional regulatory effect on neural excitability. DL-Kynurenine can enhance the convulsive and lethal effects caused by strychnine. DL-Kynurenine is the precursor of Kynurenic acid (HY-100806), which is an antagonist at the glycine site of NMDA receptors and can counteract excitatory toxins. DL-Kynurenine can be used for research on neurotoxicity.
    DL-Kynurenine-d<sub>7</sub>
  • HY-B0442CR
    Vardenafil dihydrochloride (Standard)
    Vardenafil (dihydrochloride) (Standard) is the analytical standard of Vardenafil (dihydrochloride). This product is intended for research and analytical applications. Vardenafil dihydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil dihydrochloride shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM respectively, while IC50s are >1000 nM for PDE3 and PDE4. Vardenafil dihydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil dihydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes-.
    Vardenafil dihydrochloride (Standard)
  • HY-W680647
    MDL 72527 free base
    MDL 72527 free base is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 free base shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects.
    MDL 72527 free base
  • HY-128417S
    alpha-D-glucose-d12
    alpha-D-glucose-d12 is the deuterium labeled alpha-D-glucose. alpha-D-glucose is an endogenous metabolite.
    alpha-D-glucose-d<sub>12</sub>
  • HY-32349S2
    Ercalcidiol-d9
    Ercalcidiol-d9 (25-Hydroxy Vitamin D2-d9) is the deuterium labeled Ercalcidiol (HY-32349). Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.
    Ercalcidiol-d<sub>9</sub>
  • HY-P2969
    Complement factor I
    Complement factor I is a serine protease that downregulates complement activity in the fluid phase and/or on cell surfaces in conjunction with one of its cofactors, factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein (C4BP) or membrane cofactor protein (MCP/CD46).
    Complement factor I
  • HY-N12106
    Neosartoricin
    Neosartoricin (Fumicycline) (Compound 3), a prenylated anthracenone, is a microbial secondary metabolite. Neosartoricin can be isolated from Aspergillus fumigatus and Neosartorya fischeri. Neosartoricin has immunosuppressive activity, and significantly inhibits T-cell proliferative activity with an IC50 of 3 μM. Neosartoricin may be beneficial to fungal defense, facilitating infection through suppressing the host adaptive immunity without involvement of primary virulence.
    Neosartoricin
  • HY-B0400AS
    L-Sorbitol-13C
    L-Sorbitol-13C is the 13C labeled L-Sorbitol.
    L-Sorbitol-<sup>13</sup>C
  • HY-113293S1
    Estrone sulfate-d4 TEA
    Estrone sulfate-d4 TEA is the deuterium labeled Estrone sulfate TEA. Estrone sulfate is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estrone sulfate is also a substrate of the OATP1B3 transporter. Estrone sulfate can be converted into Estrone and Estradiol in normal mammary parenchymal cells. Estrone sulfate stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion into Estrone and Estradiol occurring both in vivo and in vitro during this process. Estrone sulfate is applicable to breast cancer-related research.
    Estrone sulfate-d<sub>4</sub> TEA
  • HY-113150S2
    Hexanoylglycine-13C2,15N
    Hexanoylglycine-13C2,15N is the 13C- and 15N-labeled Hexanoylglycine (HY-113150). Hexanoylglycine is an endogenous metabolite present in Urine that can be used for the research of Ethylmalonic Encephalopathy.
    Hexanoylglycine-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N
  • HY-N16427
    2,3,-Dihydroxybenzoylserine
    2,3,-Dihydroxybenzoylserine (2,3-Dihydroxy-N-benzoylserine) is a conjugate of 2,3-dihydroxybenzoic acid and serine. 2,3,-Dihydroxybenzoylserine can be isolated from the culture of E.coli. 2,3,-Dihydroxybenzoylserine is a growth factor with growth-promoting activity in multiple aromatic auxotrophs such as E.coli KI2, strain AB2830. 2,3,-Dihydroxybenzoylserine is a degradation product of biological active compounds.
    2,3,-Dihydroxybenzoylserine
  • HY-B0282AS2
    Acetylcholine-d13 bromide
    		98.55%
    Acetylcholine-d13 (bromide) is the deuterium labeled Acetylcholine bromide.
    Acetylcholine-d<sub>13</sub> bromide
  • HY-138110R
    Toladryl (Standard)
    Toladryl (Standard) is the analytical standard of Toladryl. This product is intended for research and analytical applications. Toladryl is a derivative of Diphenhydramine (HY-B0303), capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303). The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases.
    Toladryl (Standard)
  • HY-130666
    Chlorambucyl-proline
    Chlorambucyl-proline is a chloroplatinyl amino acid derivative with inhibitory activity against bovine pulmonary vasoconstrictor enzyme. Chlorambucyl-proline reacts with the convertase in a 1:1 ratio, and the removal of its radiolabel indicates that the compound has an irreversible inhibitory effect on the enzyme activity. Chlorambucyl-proline binds to the aspartic acid or glutamic acid side chain of the enzyme by forming an ester bond, resulting in irreversible inactivation of the enzyme. The inactivation rate constant of chlororambucyl-proline increases in the pH range of 5-8, indicating that its effect on the enzyme activity is affected by the pH environment.
    Chlorambucyl-proline
  • HY-N14363
    Fistupyrone
    Fistupyrone, an antibiotic, is a microbial metabolite found in Streptomyces sp. TP-A0569. Fistupyrone inhibits Alternaria brassicicola infected Chinese cabbage.
    Fistupyrone
Cat. No. Product Name / Synonyms Application Reactivity
Endogenous Metabolite Isoform Comparison

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