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Referencia número: HY-W680647

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MDL 72527 free base

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

MDL 72527 free base is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 free base shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects.

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No. CAS: 99207-33-7
Fòrmula: C₁₂H₂₀N₂
Peso molecular:192.30

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

MDL 72527 free base Chemical Structure

No. CAS: 99207-33-7

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Descripciòn

MDL 72527 free base is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 free base shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects^[1]^[2].

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Chemical Information

No. CAS 99207-33-7
Peso molecular 192.30
Fòrmula C₁₂H₂₀N₂
SMILES

C=C=CCNCCCCNCC=C=C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Nature

Spermine is an endogenous iron chelator that inhibits ferroptosis. [Abstract]

2026 Jul;655(8121):240-250. PMID: 42236947
Proc Natl Acad Sci U S A

Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer. [Abstract]

2024 Mar 26;121(13):e2319429121. PMID: 38513095

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Doğan A, et al. Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J Neurochem. 1999 Feb;72(2):765-70. [Content Brief]

[2]. Agostinelli E, et al. Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. Biochim Biophys Acta. 2006 Oct;1763(10):1040-50. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MDL 72527 free base

2 Cited Publications

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MDL 72527 free base

Publications Citing Use of MedChemExpress (MCE) MDL 72527 free base

Ver todos los productos específicos de isoformas Endogenous Metabolite

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Publications (2)

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MDL 72527 free base Related Classifications

HY-W680647 Related Classifications