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Cat. No.: HY-W680647

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MDL 72527 free base

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

MDL 72527 free base is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 free base shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects.

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CAS No.: 99207-33-7
Formule: C₁₂H₂₀N₂
Masse moléculaire:192.30

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Data Sheet (264 KB)

MDL 72527 free base Chemical Structure

CAS No.: 99207-33-7

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Description

MDL 72527 free base is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 free base shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects^[1]^[2].

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Chemical Information

CAS No. 99207-33-7
Masse moléculaire 192.30
Formule C₁₂H₂₀N₂
SMILES

C=C=CCNCCCCNCC=C=C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Nature

Spermine is an endogenous iron chelator that inhibits ferroptosis. [Abstract]

2026 Jul;655(8121):240-250. PMID: 42236947
Proc Natl Acad Sci U S A

Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer. [Abstract]

2024 Mar 26;121(13):e2319429121. PMID: 38513095

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Doğan A, et al. Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J Neurochem. 1999 Feb;72(2):765-70. [Content Brief]

[2]. Agostinelli E, et al. Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. Biochim Biophys Acta. 2006 Oct;1763(10):1040-50. [Content Brief]

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MDL 72527 free base

2 Cited Publications

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MDL 72527 free base

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Voir tous les produits spécifiques à Isoform Endogenous Metabolite

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Publications (2)

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MDL 72527 free base Related Classifications

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