2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health[1][2][3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets[1][2][3].

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison
Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-W015828R
    Ompenaclid (Standard)
    Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy.
    Ompenaclid (Standard)
  • HY-N0814B
    Phytic acid hexasodium
    Phytic acid (Inositol hexaphosphate) hexasodium is a phosphorus storage compound of seeds and cereal grains. Phytic acid hexasodium has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid hexasodium inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.
    Phytic acid hexasodium
  • HY-126044
    6-Hydroxy bexarotene
    6-Hydroxy bexarotene is the main circulating metabolite of bexarotene, found in rats, dogs, and humans. Compared to the parent compound, 6-hydroxy-bexarotene shows a significantly reduced ability to bind to retinoid receptors and exhibits very minimal activity in activating retinoic acid receptors.
    6-Hydroxy bexarotene
  • HY-W412215
    TTMAPP
    TTMAPP is a photocatalyst with the activity of promoting organic reactions. TTMAPP is widely used in chemical synthesis, especially in oxidation and reduction reactions. TTMAPP can also be used as a synthetic intermediate for bioactive molecules, which is of great significance for compound development.
    TTMAPP
  • HY-164997
    15-keto Prostaglandin F1α
    15-keto Prostaglandin F1α (15-keto PGF1α) is a prostaglandin F1α metabolite. 15-keto Prostaglandin F1α (15-keto PGF1α) is an effective substrate for PGR-2. 15-keto Prostaglandin F1α (15-keto PGF1α) can be used to study physiological processes such as prostaglandin metabolism and lipogenesis.
    15-keto Prostaglandin F1α
  • HY-126182
    Deacetyldiltiazem
    Deacetyldiltiazem is a metabolite with coronary vasodilator activity. Deacetyldiltiazem is present in the plasma of individuals taking Diltiazem. The deacetylase activity of deacetyldiltiazem is mainly catalyzed by the rat Ces2a enzyme. In vitro experiments of deacetyldiltiazem showed that its Km value was similar to that of rat liver microsomes, showing efficient deacetylase activity. The study of deacetyldiltiazem helps to understand the differences in the metabolic kinetics of compounds between different species.
    Deacetyldiltiazem
  • HY-W004661R
    1,4-Dioxane-2,5-diol (Standard)
    1,4-Dioxane-2,5-diol (Standard) (Hydroxy Acetaldehyde (Standard)) is the analytical standard of 1,4-Dioxane-2,5-diol (HY-W004661). This product is intended for research and analytical applications. 1,4-Dioxane-2,5-diol is an endogenous metabolite.
    1,4-Dioxane-2,5-diol (Standard)
  • HY-W354498R
    L-Octanoylcarnitine hydrochloride (Standard)
    L-Octanoylcarnitine (hydrochloride) (Standard) is the analytical standard of L-Octanoylcarnitine (hydrochloride) (HY-W354498). This product is intended for research and analytical applications. L-Octanoylcarnitine hydrochloride is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine hydrochloride can be used for the research of breast cancer.
    L-Octanoylcarnitine hydrochloride (Standard)
  • HY-113056AR
    N1-Acetylspermidine hydrochloride (Standard)
    N1-Acetylspermidine (hydrochloride) (Standard) is the analytical standard of N1-Acetylspermidine (hydrochloride). This product is intended for research and analytical applications. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research.
    N1-Acetylspermidine hydrochloride (Standard)
  • HY-124273
    C2 L-threo Ceramide (d18:1/2:0)
    C2 L-threo Ceramide (d18:1/2:0) (L-threo Cer(d18:1/2:0); L-threo Ceramide (d18:1/2:0)) is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide. C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.
    C2 L-threo Ceramide (d18:1/2:0)
  • HY-32351AR
    Calcifediol monohydrate (Standard)
    Calcifediol monohydrate (Standard) is the analytical standard of Calcifediol (monohydrate). This product is intended for research and analytical applications. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels.
    Calcifediol monohydrate (Standard)
  • HY-W004078R
    4-Hydroxybenzylamine (Standard)
    4-Hydroxybenzylamine (Standard) is the analytical reference standard of 4-Hydroxybenzylamine (HY-W004078). This product is used for research and analytical applications. 4-Hydroxybenzylamine is a natural biogenic amine. 4-Hydroxybenzylamine can be produced through the breakdown metabolism of glucosinolates, with glutamine serving as the non-classical ammonia donor. 4-Hydroxybenzylamine can be used for studying the biosynthesis of plant amines.
    4-Hydroxybenzylamine (Standard)
  • HY-W011195R
    Calcium 2-hydroxy-4-(methylthio)butanoate (Standard)
    Calcium 2-hydroxy-4-(methylthio)butanoate (Standard) is the analytical standard of Calcium 2-hydroxy-4-(methylthio)butanoate (HY-W011195). This product is intended for research and analytical applications. Calcium 2-hydroxy-4-(methylthio)butanoate is an endogenous metabolite.
    Calcium 2-hydroxy-4-(methylthio)butanoate (Standard)
  • HY-W099643
    Cis-13-docosenol
    Cis-13-docosenol (Erucyl alcohol) is a long-chain alcohol pheromone in insects. Cis-13-docosenol exhibits attractive effects on both male and female adult Holotrichia parallela. Cis-13-docosenol can be used for the monitoring and control of adult Holotrichia parallela.
    Cis-13-docosenol
  • HY-125473
    IDX375
    IDX375 is a novel non-nucleoside inhibitor with selective inhibitory activity against HCV NS5B. IDX375 has good selectivity for genotypes 1a and 1b. The structure and binding site of IDX375 were confirmed by X-ray cocrystal studies.
    IDX375
  • HY-D0186S
    2'-Deoxyuridine-1′-13C
    		99.48%
    2'-Deoxyuridine-1′-13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
    2'-Deoxyuridine-1′-<sup>13</sup>C
  • HY-W854630
    60-Fulleroacetic acid
    60-Fulleroacetic acid can be used to study its behavior in non-aqueous capillary electrophoresis.
    60-Fulleroacetic acid
  • HY-B1713
    Ornithine
    Ornithine ((±)-Ornithine) is a non-essential amino acid. Ornithine is an intermediate in urea cycle and acts as a substrate for these rate limiting enzymes ornithine transcarbomylase, ornithine aminotransferase and ornithine decarboxylase producing citrulline, proline and polyamines, respectively. Ornithine can be used in the research of hyperornithinemia, hyperammonemia, and cancer.
    Ornithine
  • HY-W543065
    CPhos Pd G2
    CPhos Pd G2 is a highly efficient palladium catalyst with excellent cross-coupling reaction activity. CPhos Pd G2 is widely used in compound synthesis and material science, especially for the construction of complex organic molecules and the synthesis of bioactive compounds. CPhos Pd G2 is also favored for improving reaction selectivity and reducing the formation of by-products.
    CPhos Pd G2
  • HY-N18901
    3-(2-Hydroxy-1-methyl-2-nitrosohydrazinyl)-N-methyl-1-propanamine
    3-(2-Hydroxy-1-methyl-2-nitrosohydrazinyl)-N-methyl-1-propanamine is an endogenous metabolite. 3-(2-Hydroxy-1-methyl-2-nitrosohydrazinyl)-N-methyl-1-propanamine is significantly affected by low-dose citrus pectin.
    3-(2-Hydroxy-1-methyl-2-nitrosohydrazinyl)-N-methyl-1-propanamine
Cat. No. 상품명 / Synonyms Application Reactivity
Endogenous Metabolite Isoform Comparison

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