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NO Synthase

Nitric oxide synthases; NOS

NO Synthase

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Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.

NO Synthase Isoform Specific Products:

NO Synthase Isoform Comparison
Cat. No. Nombre del producto Efecto Pureza Chemical Structure
  • HY-118700AR
    2-Iminobiotin hydrobromide (Standard)
    		Inhibitor
    H-Gly-Gly-Gly-OH (Standard) is the analytical standard of H-Gly-Gly-Gly-OH. This product is intended for research and analytical applications. H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.
    2-Iminobiotin hydrobromide (Standard)
  • HY-133126A
    hDDAH-1-IN-1 TFA
    		Inhibitor
    hDDAH-1-IN-1 TFA (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a Ki of 18 μM.
    hDDAH-1-IN-1 TFA
  • HY-172451
    MC4762
    		Inhibitor
    MC4762 is an inhibitor of NOX2 and MAOB, with IC50 values of 0.155 μM and 0.182 μM, respectively. MC4762 has anti-inflammatory activity, can inhibit the production of ROS, and downregulate the expression of pro-inflammatory cytokines iNOS, IL-1β, and IL-6.
    MC4762
  • HY-18252A
    Avanafil dibenzenesulfonate
    		Inhibitor
    Avanafil (TA-1790) dibenzenesulfonate is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil dibenzenesulfonate activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil dibenzenesulfonate inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil dibenzenesulfonate can be used for the research of erectile dysfunction and osteoporosis.
    Avanafil dibenzenesulfonate
  • HY-B1041AS
    Aminoguanidine-13C, 15N4
    Aminoguanidine-13C,15N4 (Pimagedine-13C,15N4) is the 13C- and 15N-labeled Aminoguanidine (HY-B1041A). Aminoguanidine (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine has antioxidant properties. Aminoguanidine can be used in diabetic nephropathy research.
    Aminoguanidine-13C, 15N4
  • HY-152536
    iNOS inhibitor-10
    		Inhibitor
    iNOS inhibitor-10 is an iNOS inhibitor (IC50: 65 nM). iNOS inhibitor-10 has antiproliferative effect against triple negative breast cancer cells.
    iNOS inhibitor-10
  • HY-110057
    FR 409
    FK409 (NOR 3) is an oral active vascular relaxant agnet and can be isolated from microbial product. FK409 can be used for study of cardiovascular diseases.
    FR 409
  • HY-176234
    PDE4-IN-28
    		Inhibitor
    PDE4-IN-28 (Compound G1) is a PDE4D inhibitor (IC50: 29 nM). PDE4-IN-28 inhibits the production of TNF-α and NO (IC50: 13.32 and 2.32 μM, respectively). PDE4-IN-28 exhibits anti-inflammatory, antibacterial and analgesic effects in a rat pressure ulcer (PU) model and promotes HUVEC cell migration, thereby accelerating wound healing.
    PDE4-IN-28
  • HY-13683S1
    Mifepristone-13C,d3
    		Inhibitor
    Mifepristone-13C,d3 is the 13C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Mifepristone-<sup>13</sup>C,d<sub>3</sub>
  • HY-136341R
    7,8-Dihydroneopterin (Standard)
    		Activator
    Sanguinarine (Standard) is the analytical standard of Sanguinarine. This product is intended for research and analytical applications. Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.
    7,8-Dihydroneopterin (Standard)
  • HY-P11380
    Capa-2
    		Activator
    Capa-2 is a neuropeptide. Capa-2 activates calcium ion influx, stimulates the production of NO, activates soluble guanylate cyclase (sGC), increases intracellular cGMP, and drives ion and fluid secretion. Capa-2 can be used in studies of diuresis.
    Capa-2
  • HY-N15512
    Harzianol L
    		Inhibitor
    Harzianol L is found in Trichoderma sp. SCSIOW21. Harzianol L can inhibit the production of NO and exhibit anti-inflammatory activity.
    Harzianol L
  • HY-N15602
    Isosojagol
    		Inhibitor
    Isosojagol (Compound 5) is a α-Glucosidase inhibitor with an IC50 of 32.2  μM. Isosojagol can be isolated from the Roots of Dolichos trilobus. Isosojagol has anti-inflammatory activity and inhibits LPS (HY-D1056A1)-induced NO production in RAW264.7 cells. Isosojagol can be used for fracture, soft tissue injuries and rheumatoid arthritis research.
    Isosojagol
  • HY-139135
    Methyl-L-NIO hydrochloride
    		Inhibitor
    Methyl-L-NIO (compound 2d) hydrochloride is a potential selective inhibitor (IC50: 70 μM) of dimethylarginine dimethylaminohydrolase hDDAH. Methyl-L-NIO also has inhibitory activity against NO synthase. The inhibition rates of Methyl-L-NIO on different isoforms of NO synthase at a concentration of 100 μM are 77% (nNOS), 20% (eNOS), and 72% (iNOS) respectively; the inhibition rates at a concentration of 1 mM are 100% (nNOS), 85% (eNOS), 100% (iNOS).
    Methyl-L-NIO hydrochloride
  • HY-N15689
    Dichotomine E
    		Inhibitor
    Dichotomine E is a β-carboline alkaloid that can be isolated from the root of Stellaria dichotoma var. lanceolata. Dichotomine E has anti-inflammatory property for the inhibition of NO production in LPS (HY-D1056)-treated RAW264.7 cells.
    Dichotomine E
  • HY-N15509
    Harzianol K
    		Inhibitor
    Harzianol K is a novel harziane - type diterpene derivative discovered from the deep - sea sediment fungus Trichoderma sp. SCSIOW21. It has an inhibitory effect on NO production and can be used in the research of the anti - inflammatory field.
    Harzianol K
  • HY-N0948A
    (+)-Rhododendrol
    		Inhibitor
    (+)-Rhododendrol ((S)-(+)-Rhododendrol) is an anti-inflammatory agent that can suppress NO production.
    (+)-Rhododendrol
  • HY-179646
    CIAC101
    		Inhibitor
    CIAC101 is a potent and brain-penetrant TLR4 antagonist with an IC50 of 17.0 nM in NO assay. CIAC101 blocks Lipopolysaccharides (HY-D1056) (LPS)-induced NF-κB activation and reduces the expression of pro-inflammatory mediators (iNOS, IL-1β, TNF-α, and IL-6). CIAC101 robust antineuroinflammatory activity with efficacy against drug-evoked neurobehavioral adaptations. CIAC101 can be used for the research of addiction and neurological disease.
    CIAC101
  • HY-174260
    Neuroprotective agent 11
    Neuroprotective agent 11 (Compound 1a) is an orally active polyphenol compound with significant protective effects against cerebral ischemia. The main activities of Neuroprotective agent 11 include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarction volume, and improving behavioral symptoms of cerebral ischemic mice. Neuroprotective agent 11 exerts its regulatory mechanism by downregulating the expression of inflammatory factors (iNOS、COX-2) and apoptotic proteins (cleaved-Caspase3, p53). Neuroprotective agent 11 can be used in the study of cerebral ischemia-related diseases (such as ischemic stroke).
    Neuroprotective agent 11
  • HY-161255
    3,4-DAA
    		Inhibitor
    3,4-DAA is an orally active Anthranilic acid derivative with potent immunosuppressive activities. 3, 4-DAA can alleviate the severity of colitis through inhibiting Th1 cells response, promoting Th2 cytokines expression and inducing CD4+CD25+ T cells expression. 3,4-DAA suppressed expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) release from EOC20 cells induced by IFN-γ and Lipopolysaccharide.
    3,4-DAA
Cat. No. Nombre del producto / Synonyms Application Reactivity
NO Synthase Isoform Comparison

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